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公开(公告)号：US06410324B1
公开(公告)日：2002-06-25
申请号：US09844634
申请日：2001-04-27
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
IPC分类号： C12Q168
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Tumor Necrosis Factor Receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Tumor Necrosis Factor Receptor 2. Methods of using these compounds for modulation of Tumor Necrosis Factor Receptor 2 expression and for treatment of diseases associated with expression of Tumor Necrosis Factor Receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节肿瘤坏死因子受体2的表达。该组合物包含靶向编码肿瘤坏死因子受体2的核酸的反义化合物，特别是反义寡核苷酸2.使用这些化合物调节肿瘤坏死的方法 因子受体2表达和治疗与肿瘤坏死因子受体2表达相关的疾病。
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公开(公告)号：US06656732B1
公开(公告)日：2003-12-02
申请号：US09860473
申请日：2001-05-18
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
IPC分类号： C12N1585
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of src-c. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding src-c. Methods of using these compounds for modulation of src-c expression and for treatment of diseases associated with expression of src-c are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节src-c的表达。 组合物包含靶向编码src-c的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节src-c表达和治疗与src-c表达相关的疾病的方法。
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3.发明授权Antisense modulation of phospholipase A2, group VI (Ca2+-independent) expression 有权磷脂酶A2，VI（Ca2 + - 独立）表达的反义调节公开(公告)号：US06410325B1
公开(公告)日：2002-06-25
申请号：US09851896
申请日：2001-05-09
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01004 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Phospholipase A2, group VI (Ca2+-independent). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Phospholipase A2, group VI (Ca2+-independent). Methods of using these compounds for modulation of Phospholipase A2, group VI (Ca2+-independent) expression and for treatment of diseases associated with expression of Phospholipase A2, group VI (Ca2+-independent) are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节磷脂酶A2，VI（Ca 2+独立）的表达。 组合物包含靶向编码磷脂酶A2，组VI（Ca 2+独立）的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节磷脂酶A2，VI（Ca2 + - 独立）表达和治疗与磷脂酶A2，VI（Ca2 + - 独立型）表达相关的疾病的方法。
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公开(公告)号：US06870046B2
公开(公告)日：2005-03-22
申请号：US09843377
申请日：2001-04-26
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。
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5.发明授权Antisense modulation of vascular endothelial growth factor receptor-2 expression 失效血管内皮生长因子受体-2表达的反义调制公开(公告)号：US06734017B2
公开(公告)日：2004-05-11
申请号：US09967655
申请日：2001-09-28
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
IPC分类号： C07H2102
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of vascular endothelial growth factor receptor-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding vascular endothelial growth factor receptor-2. Methods of using these compounds for modulation of vascular endothelial growth factor receptor-2 expression and for treatment of diseases associated with expression of vascular endothelial growth factor receptor-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节血管内皮生长因子受体-2的表达。 组合物包含靶向编码血管内皮生长因子受体-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节血管内皮生长因子受体-2表达和治疗与血管内皮生长因子受体-2的表达相关的疾病的方法。
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6.发明授权Antisense inhibition of vascular endothelial growth factor receptor-1 expression 失效反义抑制血管内皮生长因子受体-1表达公开(公告)号：US06710174B2
公开(公告)日：2004-03-23
申请号：US09953318
申请日：2001-09-13
申请人： C. Frank Bennett , Andrew T. Watt
发明人： C. Frank Bennett , Andrew T. Watt
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of vascular endothelial growth factor receptor-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding vascular endothelial growth factor receptor-1. Methods of using these compounds for modulation of vascular endothelial growth factor receptor-1 expression and for treatment of diseases associated with expression of vascular endothelial growth factor receptor-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节血管内皮生长因子受体-1的表达。 组合物包含靶向编码血管内皮生长因子受体-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节血管内皮生长因子受体-1表达和治疗与血管内皮生长因子受体-1表达相关的疾病的方法。
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7.发明授权Antisense oligonucleotides directed against connective tissue growth factor and uses thereof 有权针对结缔组织生长因子的反义寡核苷酸及其用途公开(公告)号：US09096851B2
公开(公告)日：2015-08-04
申请号：US13532254
申请日：2012-06-25
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
摘要翻译： 本发明提供了包含能够抑制表达结缔组织因子的修饰寡核苷酸和含有其的组合物的化合物，以及治疗过度放射性疾病和纤维化疾病的方法，以及使用这些化合物减少伤口愈合引起的瘢痕形成。
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8.发明授权Method for reducing scarring during wound healing using antisense compounds directed to CTGF 有权使用针对CTGF的反义化合物在伤口愈合过程中减少瘢痕形成的方法公开(公告)号：US08946172B2
公开(公告)日：2015-02-03
申请号：US12547481
申请日：2009-08-26
申请人： Thomas A. Mustoe , Nicholas M. Dean , Mark Sisco , Zol Kryger , C. Frank Bennett
发明人： Thomas A. Mustoe , Nicholas M. Dean , Mark Sisco , Zol Kryger , C. Frank Bennett
CPC分类号： C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/31 , C12N2310/3525
摘要： This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring.
摘要翻译： 本发明提供一种在需要的受试者中减少由真皮伤口愈合引起的高血压瘢痕形成的方法，其包括以有效抑制CTGF表达的量向受试者施用抑制结缔组织生长因子（CTGF）表达的反义寡核苷酸，从而 减少肥厚性瘢痕。
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公开(公告)号：US08921331B2
公开(公告)日：2014-12-30
申请号：US13406256
申请日：2012-02-27
IPC分类号： A61K48/00 , C12N15/113 , A61K38/00
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y115/01001 , Y02P20/582 , C12N2310/3525
摘要： Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
摘要翻译： 提供了减轻患有家族性ALS的个体疾病进展的方法。 还提供了增加患有家族性ALS的个体的存活时间的方法。 这些方法使用靶向SOD1的反义寡核苷酸，用于抑制患有家族性ALS的个体的中枢神经系统中SOD1的表达。
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公开(公告)号：US20140357558A1
公开(公告)日：2014-12-04
申请号：US14129029
申请日：2012-06-25
申请人： Yimin Hua , Adrian R. Krainer , Frank Rigo , C. Frank Bennett
发明人： Yimin Hua , Adrian R. Krainer , Frank Rigo , C. Frank Bennett
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61B17/0057 , A61B2017/00455 , A61B2017/00575 , A61B2017/00601 , A61B2017/00623 , A61B2017/00676 , A61B2017/00893 , A61B2017/22069 , A61B2017/22072 , A61K38/27 , A61K38/30 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2320/33 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for treatment of diseases and disorders, including spinal muscular atrophy.
摘要翻译： 本文公开了用于治疗疾病和障碍的化合物，组合物和方法，包括脊髓性肌萎缩。
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