公开(公告)号：US20240092790A1

公开(公告)日：2024-03-21

申请号：US18267177

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Christine EDWARDS ,  Adele Elisa PASQUA ,  Prashant Bhimrao KAPADNIS ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  David Edward CLARK

IPC: C07D491/048

CPC classification number: C07D491/048

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20210284639A1

公开(公告)日：2021-09-16

申请号：US17260631

申请日：2019-07-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Anna Maria CAPELLI ,  David Edward CLARK ,  Patrizia TISSELLI ,  Christine EDWARDS ,  Amaud Jean Francois Auguste CHEGUILLAUME ,  Gurdip BHALAY

IPC: C07D471/04 ,  A61K9/00 ,  A61K31/437 ,  A61K45/06 ,  C07D519/00 ,  A61K31/496 ,  C07D487/04 ,  A61K31/519

Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20240391936A1

公开(公告)日：2024-11-28

申请号：US18283861

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Andrea RIZZI ,  Nicoió IOTTI ,  Fabio RANCATI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  David Edward CLARK ,  Toby Matthew Grover MULLINS ,  Keith Christopher KNIGHT ,  Ben Paul WHITTAKER ,  Stefano LEVANTO

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20210253568A1

公开(公告)日：2021-08-19

申请号：US16973514

申请日：2019-06-11

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  David Edward CLARK ,  Christine EDWARDS

IPC: C07D471/04 ,  A61K45/06 ,  A61K33/00 ,  A61K9/00 ,  A61K31/4725 ,  A61K31/444 ,  A61K31/506 ,  C07D487/04 ,  A61K31/519 ,  A61K31/5355 ,  C07D519/00

Abstract: The invention relates to compounds of formula I inhibiting Rho Kinase that are azaindole derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20240092791A1

公开(公告)日：2024-03-21

申请号：US18267185

申请日：2021-12-13

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Fabio RANCATI ,  Alessandro ACCETTA ,  Anna Maria CAPELLI ,  Daniele PALA ,  Christine EDWARDS ,  Adele Elisa PASQUA ,  Prashant Bhimrao KAPADNIS ,  Arnaud Jean Francois Auguste CHEGUILLAUME ,  David Edward CLARK

IPC: C07D491/048 ,  A61P11/08

CPC classification number: C07D491/048 ,  A61P11/08

Abstract: The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

公开(公告)号：US20200079774A1

公开(公告)日：2020-03-12

申请号：US16656842

申请日：2019-10-18

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Anna Maria CAPELLI ,  David Edward CLARK ,  Patrizia TISSELLI ,  Christine EDWARDS ,  Gurdip BHALAY ,  Arnaud Jean Francois Auquste CHEGUILLAUME

IPC: C07D471/04 ,  A61K9/00 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/439 ,  A61K31/444 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  C07D471/08 ,  C07D498/04 ,  C07D519/00 ,  C07D487/04

Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).