公开(公告)号：US20240391936A1

公开(公告)日：2024-11-28

申请号：US18283861

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Andrea RIZZI ,  Nicoió IOTTI ,  Fabio RANCATI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  David Edward CLARK ,  Toby Matthew Grover MULLINS ,  Keith Christopher KNIGHT ,  Ben Paul WHITTAKER ,  Stefano LEVANTO

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240425482A1

公开(公告)日：2024-12-26

申请号：US18702454

申请日：2022-10-17

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Eleonora GHIDINI ,  Nicolò IOTTI ,  Roberta MAZZUCATO ,  Stefano LEVANTO ,  Ben Paul WHITTAKER

IPC: C07D401/14 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/10

Abstract: The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.