公开(公告)号：US20240391936A1

公开(公告)日：2024-11-28

申请号：US18283861

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Andrea RIZZI ,  Nicoió IOTTI ,  Fabio RANCATI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  David Edward CLARK ,  Toby Matthew Grover MULLINS ,  Keith Christopher KNIGHT ,  Ben Paul WHITTAKER ,  Stefano LEVANTO

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240217967A1

公开(公告)日：2024-07-04

申请号：US18283851

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Nicolò IOTTI ,  Keith Christopher KNIGHT ,  Toby Matthew Grover MULLINS ,  Anna KARAWAJCZYK ,  Ben Paul WHITTAKER

IPC: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240199635A1

公开(公告)日：2024-06-20

申请号：US18283867

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZi ,  Keith Christopher KNIGHT ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS ,  Ben Paul WHITTAKER

IPC: C07D495/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541

CPC classification number: C07D495/04 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/541

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240190847A1

公开(公告)日：2024-06-13

申请号：US18283855

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS

IPC: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

Abstract: The present invention relates to compounds of general formula (I) inhibiting DDR1 and DDR2. Particularly, the invention relates to compounds that are indoline derivatives, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.

公开(公告)号：US20230227447A1

公开(公告)日：2023-07-20

申请号：US17927762

申请日：2021-05-24

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Bartosz Pawel GUT

IPC: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting DDR1 and DDR2, particularly the invention relates to compounds that are benzylamine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.