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    Site-specific incorporation of amino acids into molecules
    1.
    发明授权
    Site-specific incorporation of amino acids into molecules 有权
    位点特异性将氨基酸并入分子

    公开(公告)号：US08980581B2

    公开(公告)日：2015-03-17

    申请号：US13969368

    申请日：2013-08-16

    Applicant: California Institute of Technology

    Inventor： Pin Wang ,  Inchan Kwon ,  Soojin Son ,  Yi Tang ,  David Tirrell

    IPC: C12P21/02 ,  G01N33/68 ,  C12N9/00 ,  C12N15/67 ,  C12N15/70

    CPC classification number: C12N9/93 ,  C12N15/67 ,  C12N15/70

    Abstract: The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.

    Abstract translation: 本发明提供了涉及将非天然氨基酸并入多肽或蛋白质的方法和组合物的某些实施方案，所述方法和组合物通过利用突变或修饰的氨酰-tRNA合成酶将非天然氨基酸加载至相应的tRNA。 在某些实施方案中，tRNA也被修饰，使得复合物与通常与未修饰的tRNA /氨酰-tRNA合成酶对形成摆动碱基配对的密码子形成严格的沃森 - 克里克碱基配对。

    SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES
    2.
    发明申请
    SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES 有权
    氨基酸进入分子的特定地点

    公开(公告)号：US20140045261A1

    公开(公告)日：2014-02-13

    申请号：US13969368

    申请日：2013-08-16

    Applicant: California Institute of Technology

    Inventor： Pin Wang ,  Inchan Kwon ,  Soojin Son ,  Yi Tang ,  David Tirrell

    IPC: C12N9/00 ,  C12N15/70

    CPC classification number: C12N9/93 ,  C12N15/67 ,  C12N15/70

    Abstract: The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.

    Abstract translation: 本发明提供了涉及将非天然氨基酸并入多肽或蛋白质的方法和组合物的某些实施方案，所述方法和组合物通过利用突变或修饰的氨酰-tRNA合成酶将非天然氨基酸加载至相应的tRNA。 在某些实施方案中，tRNA也被修饰，使得复合物与通常与未修饰的tRNA /氨酰-tRNA合成酶对形成摆动碱基配对的密码子形成严格的沃森 - 克里克碱基配对。

    METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS
    3.
    发明申请
    METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS 有权
    将氨基酸类似物掺入蛋白质的方法

    公开(公告)号：US20140342451A1

    公开(公告)日：2014-11-20

    申请号：US14455581

    申请日：2014-08-08

    Applicant: California Institute of Technology

    Inventor： Inchan Kwon ,  David Tirrell

    IPC: C12N15/113

    CPC classification number: C12N15/113 ,  C07H21/02 ,  C12N9/93 ,  C12N15/70 ,  C12N2310/10 ,  C12P21/00 ,  C12P21/02

    Abstract: The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs.

    Abstract translation: 本发明提供了一种通过利用修饰的氨酰-tRNA合成酶将非标准氨基酸掺入蛋白质的方法，以将非标准氨基酸装入修饰的tRNA，其与通常形成摆动碱基的密码子形成严格的沃森 - 克里克碱基配对， 与天然tRNA配对。

    Methods of incorporating amino acid analogs into proteins
    4.
    发明授权
    Methods of incorporating amino acid analogs into proteins 有权
    将氨基酸类似物掺入蛋白质的方法

    公开(公告)号：US08835162B2

    公开(公告)日：2014-09-16

    申请号：US13730116

    申请日：2012-12-28

    Applicant: California Institute of Technology

    Inventor： Inchan Kwon ,  David Tirrell

    IPC: C12N15/70

    CPC classification number: C12N15/113 ,  C07H21/02 ,  C12N9/93 ,  C12N15/70 ,  C12N2310/10 ,  C12P21/00 ,  C12P21/02

    Abstract: The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA, which forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with natural tRNAs.

    Abstract translation: 本发明提供了一种通过利用修饰的氨酰-tRNA合成酶将非标准氨基酸掺入蛋白质的方法，以将非标准氨基酸装入修饰的tRNA，其与通常形成摆动碱基的密码子形成严格的沃森 - 克里克碱基配对， 与天然tRNA配对。

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