公开(公告)号：US11510905B1

公开(公告)日：2022-11-29

申请号：US17239583

申请日：2021-04-24

申请人： Chengyuan Liang ,  Wenjing Yang ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Ruina Bian ,  Jie Zhang ,  Yuqing Zhao ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Liang Qi ,  Gennian Mao

发明人： Chengyuan Liang ,  Wenjing Yang ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Ruina Bian ,  Jie Zhang ,  Yuqing Zhao ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Liang Qi ,  Gennian Mao

IPC分类号： C07D233/60 ,  A61K31/4164 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11512049B2

公开(公告)日：2022-11-29

申请号：US17239582

申请日：2021-04-24

申请人： Qianqian Zhao ,  Yuqing Zhao ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Ruina Bian ,  Jie Zhang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang ,  Liang Qi ,  Gennian Mao

发明人： Qianqian Zhao ,  Yuqing Zhao ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Ruina Bian ,  Jie Zhang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang ,  Liang Qi ,  Gennian Mao

IPC分类号： C07C323/52 ,  A61P31/04 ,  C07C319/28

摘要： A compound with anti-drug resistant bacteria activity having the formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11518740B2

公开(公告)日：2022-12-06

申请号：US17239575

申请日：2021-04-24

申请人： Qianqian Zhao ,  Jie Zhang ,  Liang Xin ,  Jingyi Li ,  Ruina Bian ,  Yuqing Zhao ,  Dan Yang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang

发明人： Qianqian Zhao ,  Jie Zhang ,  Liang Xin ,  Jingyi Li ,  Ruina Bian ,  Yuqing Zhao ,  Dan Yang ,  Han Li ,  Bin Tian ,  Yongbo Wang ,  Chengyuan Liang

IPC分类号： C07C323/52 ,  C07C319/20

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11555016B2

公开(公告)日：2023-01-17

申请号：US17157916

申请日：2021-01-25

申请人： Yongbo Wang ,  Han Li ,  Gennian Mao ,  Bin Tian ,  Dan Yang ,  Chengyuan Liang ,  Xiuding Yang ,  Wenbo Yao ,  Guaiping Qiao ,  Nan Hui ,  Juan Li ,  Liang Xin ,  Jingyi Li ,  Ruina Bian

发明人： Yongbo Wang ,  Han Li ,  Gennian Mao ,  Bin Tian ,  Dan Yang ,  Chengyuan Liang ,  Xiuding Yang ,  Wenbo Yao ,  Guaiping Qiao ,  Nan Hui ,  Juan Li ,  Liang Xin ,  Jingyi Li ,  Ruina Bian

IPC分类号： C07D215/233 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11117859B1

公开(公告)日：2021-09-14

申请号：US17175575

申请日：2021-02-12

申请人： Dan Yang ,  Jingyi Li ,  Liang Xin ,  Qianqian Zhao ,  Liang Qi ,  Bin Tian ,  Jian Zha ,  Wenbo Yao ,  Gennian Mao ,  Han Li ,  Chunyang Shi ,  Yongbo Wang ,  Jingwen Xu

发明人： Dan Yang ,  Jingyi Li ,  Liang Xin ,  Qianqian Zhao ,  Liang Qi ,  Bin Tian ,  Jian Zha ,  Wenbo Yao ,  Gennian Mao ,  Han Li ,  Chunyang Shi ,  Yongbo Wang ,  Jingwen Xu

IPC分类号： C07C231/24 ,  C07C233/83 ,  C07C231/12

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US11597714B2

公开(公告)日：2023-03-07

申请号：US17128103

申请日：2020-12-19

申请人： Chengyuan Liang ,  Cong Du ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Nan Hui ,  Guaiping Qiao ,  Han Li ,  Yanjun Li ,  Liang Qi ,  Wenbo Yao ,  Gennian Mao

发明人： Chengyuan Liang ,  Cong Du ,  Qianqian Zhao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Nan Hui ,  Guaiping Qiao ,  Han Li ,  Yanjun Li ,  Liang Qi ,  Wenbo Yao ,  Gennian Mao

IPC分类号： C07D339/04 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US11712457B2

公开(公告)日：2023-08-01

申请号：US17173622

申请日：2021-02-11

申请人： Qianqian Zhao ,  Jialin Li ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Chunyang Shi ,  Xiaolin Xie ,  Dezhu Zhang ,  Ruina Bian ,  Xingke Ju ,  Chengyuan Liang ,  Yanjun Li ,  Qiao Zeng

发明人： Qianqian Zhao ,  Jialin Li ,  Dan Yang ,  Jingyi Li ,  Liang Xin ,  Chunyang Shi ,  Xiaolin Xie ,  Dezhu Zhang ,  Ruina Bian ,  Xingke Ju ,  Chengyuan Liang ,  Yanjun Li ,  Qiao Zeng

IPC分类号： A61K36/63 ,  A61P31/04 ,  A61K47/44 ,  A61K31/7034 ,  A61K31/7048

CPC分类号： A61K36/63 ,  A61K31/7034 ,  A61K31/7048 ,  A61K47/44 ,  A61P31/04 ,  A61K2236/15 ,  A61K2236/333 ,  A61K2236/35 ,  A61K2236/37 ,  A61K2236/51 ,  A61K2236/53

摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

公开(公告)号：US11155514B1

公开(公告)日：2021-10-26

申请号：US17128102

申请日：2020-12-19

申请人： Bin Tian ,  Juan Li ,  Nan Hui ,  Guaiping Qiao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Han Li ,  Yanjun Li ,  Liang Qi ,  Wenbo Yao ,  Chengyuan Liang

发明人： Bin Tian ,  Juan Li ,  Nan Hui ,  Guaiping Qiao ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Han Li ,  Yanjun Li ,  Liang Qi ,  Wenbo Yao ,  Chengyuan Liang

IPC分类号： C07C69/736 ,  C07C67/56 ,  C07C67/08

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I) is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US11168049B1

公开(公告)日：2021-11-09

申请号：US17128100

申请日：2020-12-19

申请人： Yonghong Tang ,  Minghui Chang ,  Huafeng Qi ,  Bin Tian ,  Juan Li ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Han Li ,  Yanjun Li ,  Liang Qi ,  Wenbo Yao ,  Chengyuan Liang

发明人： Yonghong Tang ,  Minghui Chang ,  Huafeng Qi ,  Bin Tian ,  Juan Li ,  Liang Xin ,  Jingyi Li ,  Dan Yang ,  Han Li ,  Yanjun Li ,  Liang Qi ,  Wenbo Yao ,  Chengyuan Liang

IPC分类号： C07C69/732 ,  C07C67/08

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US11872202B2

公开(公告)日：2024-01-16

申请号：US17695741

申请日：2022-03-15

申请人： Chengyuan Liang ,  Xiuding Yang ,  Liang Xin ,  Juan Xia ,  Yuqing Zhao ,  Jie Zhang ,  Lei Tian ,  Jingyi Li ,  Shaojun Zhang ,  Qianqian Zhao

发明人： Chengyuan Liang ,  Xiuding Yang ,  Liang Xin ,  Juan Xia ,  Yuqing Zhao ,  Jie Zhang ,  Lei Tian ,  Jingyi Li ,  Shaojun Zhang ,  Qianqian Zhao

IPC分类号： A61K31/216 ,  A61P31/04

CPC分类号： A61K31/216 ,  A61P31/04

摘要： A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)




R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.