公开(公告)号：US08470978B2

公开(公告)日：2013-06-25

申请号：US12746269

申请日：2008-12-05

Applicant: Christopher Gregory

Inventor： Christopher Gregory

IPC: C07K16/00 ,  G01N33/53 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/567 ,  G01N33/6854 ,  G01N2510/00

Abstract: Described are methods of separating viable cells, apoptotic cells and dead cells and antibodies or use in such methods. The antibodies may also be used in treatment of inflammatory disease, cancer and in wound healing.

Abstract translation: 描述了分离活细胞，凋亡细胞和死细胞和抗体或在这些方法中使用的方法。 抗体也可用于治疗炎性疾病，癌症和伤口愈合。

公开(公告)号：US20060142186A1

公开(公告)日：2006-06-29

申请号：US11179608

申请日：2005-07-13

Applicant: Christopher Gregory ,  Patrick Smith

Inventor： Christopher Gregory ,  Patrick Smith

IPC: A61K38/09 ,  A61K31/55 ,  A61K31/445

CPC classification number: A61K31/55 ,  A61K31/445 ,  A61K38/09 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods of treating, mitigating, slowing the progression of, or preventing Alzheimer's Disease include administration of gonadotropin-releasing hormone analogues in combination with acetylcholinesterase inhibitors and/or N-methyl-D-aspartate receptor antagonists.

Abstract translation: 治疗，减轻，减缓或预防阿尔茨海默氏病的方法包括与乙酰胆碱酯酶抑制剂和/或N-甲基-D-天冬氨酸受体拮抗剂组合施用促性腺激素释放激素类似物。

公开(公告)号：US20060058577A1

公开(公告)日：2006-03-16

申请号：US11200747

申请日：2005-08-10

Applicant: Geraint Davies ,  John Cline ,  Christopher Gregory ,  Alan Cucknell ,  Julian Scarfe ,  Pete Cauwood

Inventor： Geraint Davies ,  John Cline ,  Christopher Gregory ,  Alan Cucknell ,  Julian Scarfe ,  Pete Cauwood

IPC: A61F2/02

CPC classification number: A61F5/441 ,  A61F5/4404 ,  A61F5/445

Abstract: A stoma seal is described for a controlled evacuation ostomy appliance. The stoma seal may have a liquid-responsive property, such as hydrophobic, hydrophilic or absorptive. The stoma seal may have a non-smooth surface, e.g., at a microstructure scale. The non-smooth surface may consist of tortuous channels, protruding seals, or a confronting apertured or porous layer. The liquid-responsive property and/or the non-smooth surface may facilitate separation of flatus from faecal matter and/or facilitate venting of flatus while obstructing stool.

Abstract translation: 描述了一种可控疏散造口术装置的造口密封。 造口密封件可具有液体响应特性，例如疏水性，亲水性或吸收性。 造口密封件可以具有非平滑表面，例如微结构尺度。 非光滑表面可以由曲折的通道，突出的密封件或面对的有孔或多孔层组成。 液体反应性质和/或非光滑表面可以促进肠胃和粪便物质的分离和/或促进肠胃排出，同时阻塞粪便。

公开(公告)号：US20050137526A1

公开(公告)日：2005-06-23

申请号：US10738857

申请日：2003-12-17

Applicant: Fidelis Machado ,  Christopher Gregory

Inventor： Fidelis Machado ,  Christopher Gregory

IPC: A61M25/00 ,  A61F2/00 ,  A61F2/958 ,  A61M25/01 ,  A61M29/00

CPC classification number: A61M25/01

Abstract: The invention relates to a balloon catheter in which the balloon is mounted on the end of the catheter in a manner that creates a recess or pocket between the catheter wall and balloon wall. The recess or pocket opens toward the proximal end of the catheter. The rigid end of an introducer element or finger is received in the recess to attach it to the catheter. The distal end of the catheter, with the end of the introducer element in the recess, is inserted and positioned within the bowel by manipulating the introducer element or finger. After the catheter is properly positioned in the bowel, the introducer element or finger is withdrawn, detaching it from the catheter as the end of the introducer element slides out of the recess and then out of the bowel. The balloon is inflated prior to or after the withdrawal of the introducer element to anchor the end of the catheter in position within the bowel. Since the distal end of the catheter is made entirely of soft, compliant material, no soft tissue damage can occur from use of the device, even when the catheter remains in place within the body over an extended time period.

Abstract translation: 本发明涉及一种球囊导管，其中气囊以在导管壁和球囊壁之间产生凹陷或凹陷的方式安装在导管的端部上。 凹槽或口袋朝向导管的近端开口。 导引器元件或手指的刚性端部容纳在凹部中以将其附接到导管。 通过操纵导引器元件或手指将引导器元件的端部插入凹槽中的导管的远端插入并定位在肠内。 在将导管适当地定位在肠内之后，导引器元件或手指被取出，当导引器元件的端部滑出凹槽，然后从肠排出时，将其从导管中分离出来。 导引器元件撤出之前或之后使气囊膨胀，以将导管的端部锚固在肠内的适当位置。 由于导管的远端完全由柔软的顺应性材料制成，所以即使导管在延长的时间内保持在体内就位，也不会因使用该装置而发生软组织损伤。

公开(公告)号：US20050054996A1

公开(公告)日：2005-03-10

申请号：US10929136

申请日：2004-08-28

Applicant: Christopher Gregory

Inventor： Christopher Gregory

IPC: A61M31/00 ,  A61F5/44 ,  A61F5/442 ,  A61F5/445 ,  A61M1/00 ,  A61M3/00 ,  A61M3/02 ,  A61M5/00 ,  A61M25/00 ,  A61M25/01 ,  A61M25/04

CPC classification number: A61F5/445 ,  A61F5/442 ,  A61M3/0283 ,  A61M3/0295 ,  A61M25/0119 ,  A61M31/00 ,  A61M2210/1064

Abstract: The end of the elongated tubular element of the appliance that is designed to be inserted into a body cavity or vessel is formed entirely of soft, compliant material. That end carries an inflatable balloon formed in its fully inflated shape. The balloon is inflated to a predetermined low pressure level to prevent pressure necrosis in the adjacent tissue. A method and apparatus for introducing the soft end of the appliance into the body cavity are also provided. The introducer apparatus includes rigid core surrounded by a soft, compliant sleeve. The sleeve extends beyond the rigid core to form an invertable section. The soft end of the appliance is situated adjacent the apparatus, the balloon is wrapped around the apparatus, and the sleeve section is inverted over the appliance, compressing the balloon and forming a soft, rounded insertion tip. The unit is then introduced into the body cavity. After the appliance is separated from the apparatus, the apparatus is withdrawn.

Abstract translation: 被设计成插入到体腔或容器中的器具的细长管状元件的端部完全由柔软的柔性材料形成。 该端部装有形成为其完全膨胀形状的可膨胀气囊。 气囊膨胀至预定的低压水平以防止邻近组织中的压力坏死。 还提供了用于将器具的软端引入体腔的方法和装置。 导引器装置包括由软的柔性套筒包围的刚性芯。 套筒延伸超过刚性芯以形成可逆的部分。 器具的软端位于设备附近，气囊被包裹在设备周围，并且套筒部分在器具上翻转，压缩气囊并形成软的圆形插入尖端。 然后将该单元引入体腔。 在器具与设备分离后，设备被取出。

公开(公告)号：US10166138B2

公开(公告)日：2019-01-01

申请号：US12664169

申请日：2008-06-11

Applicant: John Cline ,  Bret Weig ,  Christopher Gregory ,  John Blum

Inventor： John Cline ,  Bret Weig ,  Christopher Gregory ,  John Blum

IPC: A61F5/44 ,  A61F5/445

Abstract: A stoma adapter is described that is especially suited to a recessed stoma or a flush stoma. The stoma adapter effectively extends the discharge passage from the stoma, protects peristomal skin, and forms a bridge at the interface between the stoma and an ostomy appliance. The stoma adapter contains a substantially unobstructed discharge passage, at least for effluent flowing in a discharge direction. The stoma adapter includes a seal for sealing against the bowel wall. The stoma adapter has collapsing, expanding, flexible and reinforced designs.

公开(公告)号：US08858520B2

公开(公告)日：2014-10-14

申请号：US12988826

申请日：2009-04-21

Applicant: Christopher Gregory

Inventor： Christopher Gregory

IPC: A61F5/44 ,  A61F5/445

CPC classification number: A61F5/445

Abstract: A temporary ostomy appliance is disclosed, including a catheter for extending through the abdominal wall into the intestine. The catheter may be a transcecal catheter for extending through the cecal valve into the ileum. A portion of a catheter that extends through the cecal valve is made collapsible when the catheter is empty. The collapsed portion expands to permit passage of effluent. A balloon carried on the catheter is preformed with a shape and size in order to permit inflation without elastic stretching of the balloon wall material. A filament is provided for permitting a portion of the catheter to be fastened to internal body tissue by surgical sutures or staples. In order to release the fastening without further surgery, the filament is withdrawn by pulling on a proximal portion outside the body.

Abstract translation: 公开了一种临时造口术器具，包括用于延伸穿过腹壁进入肠内的导管。 导管可以是用于延伸通过盲肠阀进入回肠的超导管。 当导管是空的时，延伸穿过盲肠阀的导管的一部分被制成可折叠的。 折叠部分膨胀以允许流出物通过。 携带在导管上的气球预成形为具有形状和尺寸，以允许充气而不弹性地延伸球囊壁材料。 提供细丝以允许导管的一部分通过外科缝合线或钉钉紧固到内部身体组织。 为了在没有进一步手术的情况下释放紧固件，通过拉动身体外部的近端部分来取出细丝。

公开(公告)号：US20110040231A1

公开(公告)日：2011-02-17

申请号：US12988826

申请日：2009-04-21

Applicant: Christopher Gregory

Inventor： Christopher Gregory

IPC: A61M5/00 ,  A61M29/00

CPC classification number: A61F5/445

Abstract: A temporary ostomy appliance is disclosed, including a catheter for extending through the abdominal wall into the intestine. The catheter may be a transcecal catheter for extending through the cecal valve into the ileum. A portion of a catheter that extends through the cecal valve is made collapsible when the catheter is empty. The collapsed portion expands to permit passage of effluent. A balloon carried on the catheter is preformed with a shape and size in order to permit inflation without elastic stretching of the balloon wall material. A filament is provided for permitting a portion of the catheter to be fastened to internal body tissue by surgical sutures or staples. In order to release the fastening without further surgery, the filament is withdrawn by pulling on a proximal portion outside the body.

Abstract translation: 公开了一种临时造口术器具，包括用于延伸穿过腹壁进入肠内的导管。 导管可以是用于延伸通过盲肠阀进入回肠的超导管。 当导管是空的时，延伸穿过盲肠阀的导管的一部分被制成可折叠的。 折叠部分膨胀以允许流出物通过。 携带在导管上的气球被预先形成为具有形状和尺寸，以便允许充气而不弹性地延伸球囊壁材料。 提供细丝以允许导管的一部分通过外科缝合线或钉钉固定到内部身体组织。 为了在没有进一步手术的情况下释放紧固件，通过拉动身体外部的近端部分来取出细丝。

公开(公告)号：US07785822B2

公开(公告)日：2010-08-31

申请号：US10525893

申请日：2003-08-27

Applicant: Christopher Gregory ,  Branson W. Ritchie

Inventor： Christopher Gregory ,  Branson W. Ritchie

IPC: C12N5/07 ,  C12N5/10 ,  C12Q1/00

CPC classification number: C12Q1/26 ,  Y10S435/967

Abstract: The present invention provides methods for the detection of biliverdin in birds (avian species) and reptiles.

Abstract translation: 本发明提供了检测鸟类（禽类）和爬行动物中胆红素的方法。

公开(公告)号：US07727188B2

公开(公告)日：2010-06-01

申请号：US10738857

申请日：2003-12-17

Applicant: Fidelis Machado ,  Christopher Gregory

Inventor： Fidelis Machado ,  Christopher Gregory

IPC: A61M25/10

CPC classification number: A61M25/01

Abstract: The invention relates to a balloon catheter in which the balloon is mounted on the end of the catheter in a manner that creates a recess or pocket between the catheter wall and balloon wall. The recess or pocket opens toward the proximal end of the catheter. The rigid end of an introducer element or finger is received in the recess to attach it to the catheter. The distal end of the catheter, with the end of the introducer element in the recess, is inserted and positioned within the bowel by manipulating the introducer element or finger. After the catheter is properly positioned in the bowel, the introducer element or finger is withdrawn, detaching it from the catheter as the end of the introducer element slides out of the recess and then out of the bowel. The balloon is inflated prior to or after the withdrawal of the introducer element to anchor the end of the catheter in position within the bowel. Since the distal end of the catheter is made entirely of soft, compliant material, no soft tissue damage can occur from use of the device, even when the catheter remains in place within the body over an extended time period.

Abstract translation: 本发明涉及一种球囊导管，其中气囊以在导管壁和球囊壁之间产生凹陷或凹陷的方式安装在导管的端部上。 凹槽或口袋朝向导管的近端开口。 导引器元件或手指的刚性端部容纳在凹部中以将其附接到导管。 通过操纵导引器元件或手指将引导器元件的端部插入凹槽中的导管的远端插入并定位在肠内。 在将导管适当地定位在肠内之后，导引器元件或手指被取出，当导引器元件的端部滑出凹槽，然后从肠排出时，将其从导管中分离出来。 导引器元件撤出之前或之后使气囊膨胀，以将导管的端部锚固在肠内的适当位置。 由于导管的远端完全由柔软的顺应性材料制成，所以即使导管在延长的时间内保持在体内就位，也不会因使用该装置而发生软组织损伤。