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    Chromatography quantitative measuring apparatus
    4.
    发明授权
    Chromatography quantitative measuring apparatus 有权
    色谱定量测量仪

    公开(公告)号：US08722425B2

    公开(公告)日：2014-05-13

    申请号：US12641903

    申请日：2009-12-18

    申请人： Koji Miyoshi ,  Masahiro Aga ,  Kaoru Shigematsu

    发明人： Koji Miyoshi ,  Masahiro Aga ,  Kaoru Shigematsu

    IPC分类号： G01N33/558

    CPC分类号： G01N30/90 ,  G01N21/8483 ,  G01N30/95 ,  G01N33/542 ,  G01N33/54386 ,  G01N33/558 ,  Y10S435/967 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

    摘要： In a chromatography quantitative measuring apparatus according to the present invention, a beam applied from a light source to a chromatography test strip is formed into an elliptical shape by an optical means such as a cylindrical lens, a variation in absorbance that accompanies elution of a marker regent is detected while the elliptical beam is applied between a marker reagent hold part and a detection part, and a measurement is automatically started in a prescribed period of time since the detection of variation. According to the chromatography quantitative measuring apparatus so configured, non-uniform coloration is reduced by shaping the beam elliptically with the optical means, whereby the accuracy of quantitative analysis is enhanced, and the apparatus can be operated easily.

    摘要翻译： 在根据本发明的色谱定量测量装置中，从光源施加到色谱测试条的光束通过诸如柱面透镜的光学装置形成为椭圆形，伴随着标记的洗脱的吸光度变化 当在标记试剂保持部和检测部之间施加椭圆形光束时检测摄像元件，并且在自变化检测之后的规定时间段内自动开始测量。 根据这样构成的色谱定量测定装置，通过用光学装置对光束进行椭圆形成，可以减少不均匀着色，从而提高定量分析的精度，容易操作。

    IDENTIFICATION AND MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS
    7.
    发明申请
    IDENTIFICATION AND MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS 审中-公开
    系统性红斑狼疮的鉴定和监测

    公开(公告)号：US20120122241A1

    公开(公告)日：2012-05-17

    申请号：US13358428

    申请日：2012-01-25

    申请人： Joseph M. Ahearn ,  Susan M. Manzi ,  Jeannine Navratil

    发明人： Joseph M. Ahearn ,  Susan M. Manzi ,  Jeannine Navratil

    IPC分类号： G01N21/64 ,  G01N33/566

    CPC分类号： G01N33/564 ,  G01N2800/104 ,  Y10S435/967 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/821 ,  Y10T436/101666

    摘要： A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE and/or on platelets of the individual obtained at a different time. Kits for use in the above-described methods are provided along with computer readable media tangibly embodying executable instructions to perform the methods.

    摘要翻译： 提供了一种用于识别或监视个人中的SLE的方法。 该方法包括定量血小板表面上的补体成分C4d，并比较在不同时间获得的个体的血小板上没有SLE和/或血小板上的C4d的参考水平与参考水平的比值。 提供了用于上述方法的套件以及有形地体现用于执行方法的可执行指令的计算机可读介质。

    Identification and monitoring of systemic lupus erythematosus
    9.
    发明授权
    Identification and monitoring of systemic lupus erythematosus 有权
    识别和监测系统性红斑狼疮

    公开(公告)号：US08126654B2

    公开(公告)日：2012-02-28

    申请号：US12538001

    申请日：2009-08-07

    申请人： Joseph M. Ahearn ,  Susan M. Manzi ,  Jeannine Navratil

    发明人： Joseph M. Ahearn ,  Susan M. Manzi ,  Jeannine Navratil

    IPC分类号： G01N33/00

    CPC分类号： G01N33/564 ,  G01N2800/104 ,  Y10S435/967 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/821 ,  Y10T436/101666

    摘要： A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE and/or on platelets of the individual obtained at a different time. Kits for use in the above-described methods are provided along with computer readable media tangibly embodying executable instructions to perform the methods.

    摘要翻译： 提供了一种用于识别或监视个人中的SLE的方法。 该方法包括定量血小板表面上的补体成分C4d，并比较在不同时间获得的个体的血小板上没有SLE和/或血小板上的C4d的参考水平与参考水平的比值。 提供了用于上述方法的套件以及有形地体现用于执行方法的可执行指令的计算机可读介质。

    Identification of toxin-binding protein involved in resistance to Cry1 toxins, and related screening methods
    10.
    发明授权
    Identification of toxin-binding protein involved in resistance to Cry1 toxins, and related screening methods 有权
    鉴定涉及抗Cry1毒素的毒素结合蛋白，以及相关筛选方法

    公开(公告)号：US08039229B2

    公开(公告)日：2011-10-18

    申请号：US10897621

    申请日：2004-07-23

    申请人： Michael J. Adang ,  Rebecca McNall ,  Juan Luis Jurat Fuentes

    发明人： Michael J. Adang ,  Rebecca McNall ,  Juan Luis Jurat Fuentes

    IPC分类号： C12Q1/00 ,  C12Q1/42 ,  G01N33/53 ,  G01N33/554 ,  G01N33/567 ,  G01N33/569 ,  A01N25/00

    CPC分类号： G01N33/573 ,  C12Q1/42 ,  G01N33/5085 ,  G01N2333/43552 ,  G01N2333/916 ,  Y10S435/832 ,  Y10S435/962 ,  Y10S435/967 ,  Y10S435/97

    摘要： The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant to Bacillus thuringiensis Cry toxins have measurably altered alkaline phosphatase (ALP) activity as compared to insects that are susceptible to Cry toxins. This and other surprising discoveries reported herein have broad implications in areas such as managing and monitoring the development of insect resistance to B.t. toxins. For example, the subject invention provides a simple and fast assay (enzymatic or otherwise) for detecting ALP activity levels and thereby monitoring the development of resistance by insects to crystal protein insect toxins. There was no prior motivation or suggestion to go about resistance monitoring using this simple and easy approach.

    摘要翻译： 本发明部分地涉及惊人的和意想不到的发现，与对于Cry毒素敏感的昆虫相比，对苏云金芽孢杆菌Cry毒素具有抗性的昆虫具有可测量的碱性磷酸酶（ALP）活性。 这里报道的这个和其他惊人的发现在诸如管理和监测对B.t.的昆虫抗性的发展的领域具有广泛的影响。 毒素 例如，本发明提供了用于检测ALP活性水平的简单且快速的测定（酶或其它），从而监测昆虫对晶体蛋白质昆虫毒素的抗性的发展。 没有事先的动机或建议，使用这种简单而简单的方法来进行阻力监测。