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公开(公告)号：US12115286B2
公开(公告)日：2024-10-15
申请号：US17843150
申请日：2022-06-17
申请人： Urotronic, Inc.
发明人： Lixiao Wang , Peter Barnett , David Hendrickson
CPC分类号： A61L29/08 , A61L29/06 , A61L29/085 , A61L29/16 , A61M25/1002 , A61M25/10185 , A61M29/02 , A61B1/307 , A61L2300/416 , A61L2300/426 , A61M2025/105 , A61M2025/1075 , A61M2202/0488 , A61M2205/0205 , A61M2210/0681 , A61M2210/1032 , A61M2210/1039 , A61M2210/105 , A61M2210/1053 , A61M2210/1057 , A61M2210/106 , A61M2210/1064 , A61M2210/1078 , A61M2210/1085 , A61M2210/1096 , A61M2210/166
摘要： Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.
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公开(公告)号：US12097288B2
公开(公告)日：2024-09-24
申请号：US17831946
申请日：2022-06-03
申请人： Cristcot LLC
发明人： Jennifer J. Davagian
IPC分类号： A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号： A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号：US12076270B2
公开(公告)日：2024-09-03
申请号：US16345920
申请日：2017-10-31
申请人： ELMEDIX NV
CPC分类号： A61F7/0053 , A61F7/0085 , A61F7/12 , A61M5/445 , A61M16/1005 , A61M16/104 , A61M16/1075 , A61N5/0625 , A61F2007/0002 , A61F2007/0055 , A61F2007/0057 , A61F2007/006 , A61F2007/0086 , A61F2007/0096 , A61F2007/126 , A61M2205/3372 , A61M2205/3606 , A61M2205/362 , A61M2210/0693 , A61M2210/1064 , A61M2210/1071 , A61M2210/1082 , A61M2230/50 , A61N2005/0659
摘要： A whole-body hyperthermia system for raising the body temperature of the entire body of an individual to a predetermined target temperature and for stabilizing the body temperature at the target temperature comprises an apparatus means for raising the body temperature at a rate of at least 1° C./hour, and at least a second thermal means for further adjusting the body temperature to the target temperature Tb. The second thermal means comprises a fluid circuit, which is at least partially within the individual, and a fluid, heated by a heat exchanger to a set temperature is circulated through the fluid circuit.
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公开(公告)号：US20240207182A1
公开(公告)日：2024-06-27
申请号：US18588938
申请日：2024-02-27
申请人： Cristcot LLC
IPC分类号： A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号： A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号：US20240207180A1
公开(公告)日：2024-06-27
申请号：US18588687
申请日：2024-02-27
申请人： Cristcot LLC
IPC分类号： A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号： A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号：US12017022B2
公开(公告)日：2024-06-25
申请号：US17287296
申请日：2018-11-16
发明人： Brian H. Craig
IPC分类号： A61M25/10
CPC分类号： A61M25/1011 , A61M25/1018 , A61M2025/1015 , A61M2025/1045 , A61M2025/105 , A61M2210/1035 , A61M2210/1039 , A61M2210/1064 , A61M2210/1078 , A61M2210/1433 , A61M2210/1475
摘要： Devices, systems for localized delivery of a chemotherapy, hormonal therapy or targeted drug/biologic therapy to a target tissue area of an internal body organ of a patient. A catheter 10 forms a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin. The drug may saturate the target tissue area and pass therethrough into the lymphatic system or interstitial space, which may serve as a reservoir of the drug for continued therapeutic treatment after withdrawal of the catheter. The chamber is evacuated at the end of the treatment session.
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公开(公告)号：US20240197629A1
公开(公告)日：2024-06-20
申请号：US18588820
申请日：2024-02-27
申请人： Cristcot LLC
IPC分类号： A61K9/02 , A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/00
CPC分类号： A61K9/025 , A61K9/0031 , A61K9/02 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61M31/007 , A61M2210/1064 , A61M2210/1067
摘要： The present invention relates, in various embodiments, to formulations comprising hydrocortisone and silicon dioxide. In additional embodiments, the invention relates to suppositories comprising hydrocortisone and silicon dioxide. The formulations of the present invention are useful for administration to patients who have gastrointestinal diseases and disorders such as, for example, inflammatory bowel disease.
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公开(公告)号：US12005206B2
公开(公告)日：2024-06-11
申请号：US17255701
申请日：2020-02-21
申请人： Urotronic, Inc.
发明人： Lixiao Wang , Peter Barnett , David Hendrickson
CPC分类号： A61M25/10 , A61L29/16 , A61L2300/416 , A61M2025/105 , A61M2025/1059 , A61M2025/1068 , A61M2210/105 , A61M2210/1057 , A61M2210/106 , A61M2210/1064 , A61M2210/1085 , A61M2210/1089
摘要： A balloon catheter for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen; the balloon catheter comprising: An elongated balloon; a coating layer overlying an exterior surface of the balloon wherein the coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent; and a length-control mechanism (600) which stretches and elongates the balloon during deflation, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.
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公开(公告)号：US11957853B2
公开(公告)日：2024-04-16
申请号：US18098370
申请日：2023-01-18
申请人： Urotronic, Inc.
发明人： Lixiao Wang , Peter Barnett , David Hendrickson
CPC分类号： A61M25/10 , A61L29/16 , A61L2300/416 , A61M2025/105 , A61M2025/1059 , A61M2025/1068 , A61M2210/105 , A61M2210/1057 , A61M2210/106 , A61M2210/1064 , A61M2210/1085 , A61M2210/1089
摘要： Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.
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公开(公告)号：US20230149672A1
公开(公告)日：2023-05-18
申请号：US18098370
申请日：2023-01-18
申请人： Urotronic, Inc.
发明人： Lixiao Wang , Peter Barnett , David Hendrickson
CPC分类号： A61M25/10 , A61L29/16 , A61L2300/416 , A61M2025/105 , A61M2025/1059 , A61M2025/1068 , A61M2210/105 , A61M2210/1057 , A61M2210/106 , A61M2210/1064 , A61M2210/1085 , A61M2210/1089
摘要： Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and/or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.
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