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公开(公告)号：US20180010151A1
公开(公告)日：2018-01-11
申请号：US15541431
申请日：2016-01-06
Applicant: DSM IP ASSETS B.V.
Inventor： René VERWAAL , Bernard MEIJRINK , Nathalie WIESSENHAAN , Brenda VONK , Johannes Andries ROUBOS
IPC: C12N15/90 , C12N15/113 , C12N9/22 , C12P23/00
CPC classification number: C12N15/905 , C12N9/22 , C12N15/102 , C12N15/113 , C12N15/81 , C12N15/902 , C12N2310/20 , C12P23/00
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a yeast host cell.
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公开(公告)号：US20240263172A1
公开(公告)日：2024-08-08
申请号：US18594869
申请日：2024-03-04
Applicant: DSM IP ASSETS B.V.
Inventor： Johannes Andries ROUBOS , Rene VERWAAL , Brenda VONK
CPC classification number: C12N15/11 , C12N9/22 , C12N15/81 , C12N2310/20 , C12N2330/51
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR transient expression construct (CTEC) for a genome editing system.
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公开(公告)号：US20200032252A1
公开(公告)日：2020-01-30
申请号：US16500717
申请日：2018-04-04
Applicant: DSM IP ASSETS B.V.
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a self-guiding integration construct for a genome editing system.
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Patent Agency Ranking
公开(公告)号：US20220235378A1
公开(公告)日：2022-07-28
申请号：US17608429
申请日：2020-04-23
Applicant: DSM IP Assets B.V.
Inventor： Brenda VONK , Adriana Christina VAN DER HOEK , Priscilla ZWARTJENS , Johannes Andries ROUBOS
IPC: C12N15/90
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-assembly gene editing system in a eukaryotic cell.
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公开(公告)号：US20200172934A1
公开(公告)日：2020-06-04
申请号：US16780063
申请日：2020-02-03
Applicant: DSM IP ASSETS B.V.
Inventor： René VERWAAL , Bernard MEIJRINK , Nathalie WIESSENHAAN , Brenda VONK , Johannes Andries ROUBOS
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR-CAS system for a yeast host cell.
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公开(公告)号：US20230287436A1
公开(公告)日：2023-09-14
申请号：US18187937
申请日：2023-03-22
Applicant: DSM IP ASSETS B.V. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Eric Mosher YOUNG , Amar GHODASARA , René VERWAAL , Johannes Andries ROUBOS , Bianca Elisabeth Maria GIELESEN , Brenda VONK , Alec A.K. NIELSEN , Christopher Ashby VOIGT
CPC classification number: C12N15/66 , C12N9/22 , C12N2310/20
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a guide-RNA expression system for a eukaryotic host cell.
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公开(公告)号：US20210071174A1
公开(公告)日：2021-03-11
申请号：US17053265
申请日：2019-05-06
Applicant: DSM IP ASSETS B.V.
Inventor： Johannes Andries ROUBOS , Rene VERWAAL , Brenda VONK
Abstract: The present invention relates to the field of molecular biology and cell biology. More specifically, the present invention relates to a CRISPR transient expression construct (CTEC) for a genome editing system.
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公开(公告)号：US20190185843A1
公开(公告)日：2019-06-20
申请号：US16319746
申请日：2016-12-15
Applicant: DSM IP ASSETS B.V.
CPC classification number: C12N15/102 , C12N15/111 , C12N15/902 , C12N2310/20 , C12Q2521/301
Abstract: The present invention is based on the advantageous use of single-stranded oligonucleotides in the in vivo (within a cell) assembly of double-stranded oligonucleotides into a single double-stranded nucleic acid construct.The present invention relates to the use of at least a first and a second single-stranded oligonucleotide in the assembly within a cell of at least two double-stranded nucleic acid molecules into a single double-stranded nucleic acid construct of pre-determined sequence, wherein the first and second single-stranded oligonucleotide are essentially complementary to each other.
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