公开(公告)号：US20230200412A1

公开(公告)日：2023-06-29

申请号：US17910297

申请日：2021-03-12

Applicant: DSM IP ASSETS, B.V.

Inventor： Ghislain SCHYNS ,  Joshua Thomas CLAYPOOL ,  John Michael GEREMIA

IPC: A23K20/163

CPC classification number: A23K20/163

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.

公开(公告)号：US20220002667A1

公开(公告)日：2022-01-06

申请号：US17292683

申请日：2019-11-08

Applicant: DSM IP ASSETS B.V.

Inventor： Lisa LAPRADE ,  Ghislain SCHYNS

IPC: C12N1/20 ,  A23K10/16

Abstract: The invention involves mutant genes that enable a Bacillus or other bacterial strain, such as Bacillus subtilis or B. licheniformis strain to overproduce acids. These genes can be inserted into a suitable strain and the resulting mutant strain can be used as a probiotic, preferably for use in animal health.

公开(公告)号：US20210395284A1

公开(公告)日：2021-12-23

申请号：US17292119

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc. ,  KALEIDO BIOSCIENCES, INC.

Inventor： Manuela BAUR ,  Estel CANET-MARTINEZ ,  Ruediger HAINZ ,  Ulrich HOELLER ,  Lisa Ann LAPRADE ,  John Michael GEREMIA ,  Ghislain SCHYNS

IPC: C07H1/00 ,  C07H3/06

Abstract: The present disclosure relates oligosaccharide preparations suitable for use in nutritional compositions such as animal feed and methods of manufacturing the described oligosaccharide preparations. The present disclosure further relates to nutritional compositions that comprise the oligosaccharide preparations. The disclosed oligosaccharide preparations can be advantageous as an animal feed due to, at least in part, their prebiotic utility and the presence of anhydro-subunit containing oligosaccharides, which can be used to detect and/or determine the presence and content of the disclosed oligosaccharide preparations in the nutritional composition.

公开(公告)号：US20240122953A1

公开(公告)日：2024-04-18

申请号：US18546264

申请日：2022-02-15

Applicant: DSM IP Assets B.V.

Inventor： Ghislain SCHYNS ,  Joshua CLAYPOOL ,  Kevin FREEMAN

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A61P31/04 ,  C12Q1/689

CPC classification number: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A61P31/04 ,  C12Q1/689 ,  C12Q2600/156

Abstract: The present disclosure relates to methods of modulating level of pathogenic E. coli (EHEC, EPEC, APEC) present in the gastrointestinal tract of an animal by administering saccharide compositions comprising an anhydro moiety. The presence/load with pathogenic E. coli strains can be assessed via the level of LEE and non-LEE pathogenic genes in the microbiome of the host animal.

公开(公告)号：US20240115669A1

公开(公告)日：2024-04-11

申请号：US18263818

申请日：2022-02-15

Applicant: DSM IP Assets B.V. ,  NOVOZYMES A/S

Inventor： Joshua CLAYPOOL ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC: A61K38/48 ,  A61K9/00 ,  A61K38/44 ,  A61K38/47 ,  A61P31/04 ,  C12Q1/689

CPC classification number: A61K38/48 ,  A61K9/0056 ,  A61K38/44 ,  A61K38/446 ,  A61K38/47 ,  A61P31/04 ,  C12Q1/689 ,  C12Y111/01006 ,  C12Y115/01001 ,  C12Y302/01017 ,  C12Q2600/156

Abstract: The present disclosure relates to methods of modulating level of E. coli present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of LEE and non-LEE pathogenic genes in the microbiome of the host animal. The present disclosure further relates to methods of modulating the virulence of pathogenic E. coli in the gastrointestinal tract of an animal by reducing the population of B. thetaiotaomicron in the gut microbiome of the animal.

公开(公告)号：US20240099335A1

公开(公告)日：2024-03-28

申请号：US18263809

申请日：2022-02-15

Applicant: DSM IP Assets B.V. ,  NOVOZYMES A/S

Inventor： Joshua CLAYPOOL ,  Aaron COWIESON ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC: A23K20/189 ,  A23K50/75

CPC classification number: A23K20/189 ,  A23K50/75 ,  C12Y302/01092

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut micro-biome improve the health and welfare of the animal. The present disclosure further relates to methods of modulating level of secondary metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of tryptophan metabolism derivates.

公开(公告)号：US20230004817A1

公开(公告)日：2023-01-05

申请号：US17779959

申请日：2020-11-23

Applicant: DSM IP Assets B.V.

Inventor： Ghislain SCHYNS ,  Britta BLOKKER ,  Joshua CLAYPOOL

IPC: G06N3/12 ,  G06T11/20 ,  G16B45/00

Abstract: A method for visualizing microbiome data is described. Respective microbes and/or genes in microbiome data stored In in a database are identified. A network comprising nodes interconnected by edges is generated in a memory of a computer, each node representing one or more identified microbes or one or more microbial metabolites, and each edge of the network representing an association between a respective pair of the one or more identified microbes or a reaction mediated between two metabolites by an enzyme encoded in the one or more identified genes, with at least some nodes and edges of the network being each associated with a condition attribute identifying a groups and/or a timestamp associated with a sample in the database. The displayed network is dynamically updated in accordance with a filtering of the microbiome data based on the condition attributed and/or the timestamp attributed. Corresponding systems and computer-readable storages are also described.

公开(公告)号：US20220125074A1

公开(公告)日：2022-04-28

申请号：US17291697

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Estel CANET-MARTINEZ ,  John Michael GEREMIA ,  Ulrich HOELLER ,  Lisa Ann LAPRADE ,  Ghislain SCHYNS

IPC: A23K20/163 ,  A23K50/10 ,  A23K50/30 ,  A23K50/75 ,  A23L33/125 ,  A61K31/702

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.

公开(公告)号：US20250160366A1

公开(公告)日：2025-05-22

申请号：US18839554

申请日：2023-02-23

Applicant: DSM IP Assets B.V.

Inventor： Elkin AMAYA ,  Estel CANET-MARTINEZ ,  Joshua Thomas CLAYPOOL ,  John Michael GEREMIA ,  Daniel Beat JOSS ,  Mohammad-Ali NEJAD-EBRAHIMI ,  Estefania PEREZ CALVO ,  Wen REN ,  Jerome SCHMEISSER ,  Ghislain SCHYNS ,  Clement SESTER

IPC: A23K20/163 ,  A23K10/18 ,  A23K20/189 ,  A23K50/30 ,  A23K50/75

Abstract: The present invention relates to a method for modulating the level of one or more secondary metabolite(s), and a use for modulating the level of one or more secondary metabolite(s) in the gastrointestinal tract of an animal.

公开(公告)号：US20240293437A1

公开(公告)日：2024-09-05

申请号：US18420540

申请日：2024-01-23

Applicant: DSM IP Assets B.V.

Inventor： Stephane DUVAL ,  John Michael GEREMIA ,  Lisa Ann LAPRADE ,  April WAGUESPACK-LEVY ,  Estefania PEREZ CALVO ,  Ghislain SCHYNS ,  Viviane VERLHAC ,  Joshua Thomas CLAYPOOL

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75

CPC classification number: A61K31/702 ,  A23K20/163 ,  A23K50/30 ,  A23K50/75

Abstract: Methods of feeding animals are disclosed wherein providing feed additives are provided that modulate the gut microbiome to improve the health, nutrition, and growth performance. Methods of modulating the microbial species present in the gastrointestinal tract of an animal are also disclosed. Such modulation includes, for example, modulating the level or function of microbial species.