公开(公告)号：US20250017254A1

公开(公告)日：2025-01-16

申请号：US18713284

申请日：2022-11-22

Applicant: DSM IP Assets B.V.

Inventor： Ross E. ZIRKLE ,  Oliver MAY

IPC: A23L33/00 ,  A23L33/12 ,  A61K31/202 ,  A61K35/68 ,  C12N1/20 ,  C12P7/6409 ,  C12R1/01

Abstract: Disclosed herein are compositions produced from microorganisms that are capable of producing high levels of docosapentaenoic acid (DPA(n-3)), and methods for producing the compositions. The invention is further directed to microbial strains and derivatives therefrom, biomasses, and microbial oils.

公开(公告)号：US20190144838A1

公开(公告)日：2019-05-16

申请号：US16300212

申请日：2017-05-11

Applicant: DSM IP Assets B.V.

Inventor： Anne-Cecile V. BAYNE ,  Ross E. ZIRKLE

IPC: C12N9/10 ,  C12N15/82

Abstract: The subject disclosure features, in one aspect, a method for producing lipids enriched for EPA, comprising modifying a microalga to increase expression of PFA1, and/or PFA3, and culturing the modified microalga under conditions which allow the expression of PFA1, and/or PFA3, wherein lipids enriched for EPA are produced. Also featured is a recombinant microalga in which PFA1, and/or PFA3, is overexpressed. Such recombinant microalgae have been demonstrated herein to produce very favorable fatty acid lipid profiles (e.g., increased levels of EPA, increased ratio of EPA:DHA, decreased levels of DPA n-6, etc.).

公开(公告)号：US20180171310A1

公开(公告)日：2018-06-21

申请号：US15579751

申请日：2016-06-06

Applicant: DSM IP Assets B.V.

Inventor： James G. METZ ,  Jun WANG ,  Bastien CHEVREUX ,  Ross E. ZIRKLE ,  Anne-Cecile BAYNE ,  James Casey LIPPMEIER

IPC: C12N9/10 ,  C12P7/64 ,  C12N15/82 ,  A23L33/115 ,  A23K20/158

Abstract: This disclosure concerns a novel modular docosahexaenoic acid (DHA) synthase and recombinant host organisms genetically modified with such synthase and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.