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    METHODS AND SYSTEMS FOR PROVIDING THERAPIES INTO THE PERICARDIAL SPACE
    2.
    发明申请
    METHODS AND SYSTEMS FOR PROVIDING THERAPIES INTO THE PERICARDIAL SPACE 有权
    将治疗提供给心脏空间的方法和系统

    公开(公告)号：US20120035587A1

    公开(公告)日：2012-02-09

    申请号：US13273521

    申请日：2011-10-14

    申请人： Daniel C. Sigg ,  Michael R. Ujhelyi ,  Mary M. Morris

    发明人： Daniel C. Sigg ,  Michael R. Ujhelyi ,  Mary M. Morris

    IPC分类号： A61M5/168 ,  A61M5/142

    CPC分类号： A61M5/14276 ,  A61B17/00234 ,  A61B17/3417 ,  A61B17/3478 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392 ,  A61M5/1723 ,  A61M2005/1405 ,  A61M2205/3523

    摘要： Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.

    摘要翻译： 公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以向心脏递送药理学特别是NO供体药物。 输注导管的近端连接器联接到输注泵，并且具有远端输注导管腔端部开口的远侧导管段设置在心包空间中。 可植入输注泵可与可植入缺血监测器结合操作以监测缺血状态并触发递送或调节药理学剂的周期性递送以最佳地治疗缺血。 患者可以操作患者活化剂，当感觉到缺血症状时患者传递由可植入输液泵接收的信号并触发推注和/或连续输注的传递。

    Methods and Systems for Accessing the Pericardial Space
    7.
    发明申请
    Methods and Systems for Accessing the Pericardial Space 有权
    用于获取心包空间的方法和系统

    公开(公告)号：US20100249729A1

    公开(公告)日：2010-09-30

    申请号：US12815624

    申请日：2010-06-15

    申请人： Mary M. Morris ,  Kenneth C. Gardeski ,  Michael R. Ujhelyi ,  Michael E. Leckrone

    发明人： Mary M. Morris ,  Kenneth C. Gardeski ,  Michael R. Ujhelyi ,  Michael E. Leckrone

    IPC分类号： A61M5/32 ,  A61N1/00

    CPC分类号： A61B17/3478 ,  A61B17/00234 ,  A61B17/3417 ,  A61B18/1492 ,  A61B2017/00247 ,  A61B2017/003 ,  A61B2017/22077 ,  A61B2017/3484 ,  A61B2017/3488 ,  A61B2017/349 ,  A61B2018/00291 ,  A61B2018/00357 ,  A61B2018/00392 ,  A61M25/0084 ,  A61M2025/0037

    摘要： Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver treatment in the pericardial space are disclosed. A steerable instrument is advanced transvenously into the right atrium of the heart, and a distal segment is deflected into the right atrial appendage. A fixation catheter is advanced employing the steerable instrument to affix a distal fixation mechanism to the atrial wall. A distal segment of an elongated medical device, e.g., a therapeutic catheter or an electrical medical lead, is advanced through the fixation catheter lumen, through the atrial wall, and into the pericardial space. The steerable guide catheter is removed, and the elongated medical device is coupled to an implantable medical device subcutaneously implanted in the thoracic region. The fixation catheter may be left in place.

    摘要翻译： 公开了通过血管系统和心房壁，特别是通过上腔静脉和右心房壁经心脏进入心包空间的方法和系统，以在心包空间中递送治疗。 一个可操纵的器械被递送到心脏的右心房，远端部分被偏转到右心耳。 使用可操纵的器械来前进固定导管，以将远端固定机构固定在心房壁上。 细长医疗装置（例如治疗性导管或电气医用引线）的远端部分通过固定导管内腔前进通过心房壁并进入心包空间。 可移动的导向导管被移除，并且细长的医疗装置被联接到皮下植入胸部区域的可植入医疗装置。 固定导管可以留在原位。

    PRESSURE MONITORING TO CONTROL DELIVERY OF THERAPEUTIC AGENT
    9.
    发明申请
    PRESSURE MONITORING TO CONTROL DELIVERY OF THERAPEUTIC AGENT 有权
    压力监测控制治疗药物的输送

    公开(公告)号：US20100274221A1

    公开(公告)日：2010-10-28

    申请号：US12767224

    申请日：2010-04-26

    申请人： Daniel C. Sigg ,  Prasanga D. Hiniduma-Lokuge ,  Mary M. Morris

    发明人： Daniel C. Sigg ,  Prasanga D. Hiniduma-Lokuge ,  Mary M. Morris

    IPC分类号： A61M5/172 ,  A61B5/03

    CPC分类号： A61B5/036 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/4839 ,  A61M5/14276 ,  A61M5/16854 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3331 ,  A61M2205/3334

    摘要： A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.

    摘要翻译： 用于调节对患有或具有肺动脉高压的风险的患者的治疗流体的递送的方法包括以预定的速率经由导管将治疗流体引入患者体内。 定位导管以将流体输送到右心室或肺动脉。 导管是单向阀，其构造成允许流体从导管流到目标位置。 该方法还包括通过监测内部导管压力来监测目标位置的压力，并且基于所监测的压力来调节治疗流体被引入导管的速率。 如果内部导管压力增加，流体被引入导管的速率增加，并且如果内部导管压力降低，则将流体引入导管的速率降低。