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    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
    1.
    发明申请
    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon 失效
    脊椎动物δ基因的核苷酸和蛋白质序列及其基础的方法

    公开(公告)号：US20070134239A1

    公开(公告)日：2007-06-14

    申请号：US11546583

    申请日：2006-10-10

    申请人： David Ish-Horowicz ,  Domingos Henrique ,  Julian Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace Gray

    发明人： David Ish-Horowicz ,  Domingos Henrique ,  Julian Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace Gray

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/30 ,  A61K38/17

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

    摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

    摘要翻译： 本发明涉及脊椎动物Delta基因的核苷酸序列，及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。 在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。 本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端， 跨膜区域，或Delta蛋白质的一种或多种EGF样重复序列或前述的任何组合。 额外提供了抗体对Delta，其衍生物和类似物。 还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

    Method of treatment using a soluble human delta protein fragment
    3.
    发明授权
    Method of treatment using a soluble human delta protein fragment 失效
    使用可溶性人类δ蛋白片段的治疗方法

    公开(公告)号：US08415303B2

    公开(公告)日：2013-04-09

    申请号：US11546583

    申请日：2006-10-10

    申请人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    发明人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    IPC分类号： A61K38/16 ,  A61K38/18

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

    摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

    摘要翻译： 本发明涉及脊椎动物Delta基因的核苷酸序列，及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。 在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。 本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端， 跨膜区域，或Delta蛋白质的一种或多种EGF样重复序列或前述的任何组合。 额外提供了抗体对Delta，其衍生物和类似物。 还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
    5.
    发明授权
    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon 有权
    脊椎动物δ基因的核苷酸和蛋白质序列及其基础的方法

    公开(公告)号：US07928071B2

    公开(公告)日：2011-04-19

    申请号：US11492497

    申请日：2006-07-24

    申请人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    发明人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    IPC分类号： A61K38/17 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

    摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

    摘要翻译： 本发明涉及脊椎动物Delta基因的核苷酸序列，及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。 在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。 本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端， 跨膜区域，或Delta蛋白质的一种或多种EGF样重复序列或前述的任何组合。 额外提供了抗体对Delta，其衍生物和类似物。 还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
    6.
    发明授权
    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon 失效
    脊椎动物δ基因的核苷酸和蛋白质序列及其基础的方法

    公开(公告)号：US06783956B2

    公开(公告)日：2004-08-31

    申请号：US09908322

    申请日：2001-07-17

    申请人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    发明人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    IPC分类号： C12P2106

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

    摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

    摘要翻译： 本发明涉及脊椎动物Delta基因的核苷酸序列，及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。 在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。 本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端， 跨膜区域，或Delta蛋白质的一种或多种EGF样重复序列或前述的任何组合。 额外提供了抗体对Delta，其衍生物和类似物。 还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
    7.
    发明授权
    Nucleotide and protein sequences of vertebrate delta genes and methods based thereon 失效
    脊椎动物δ基因的核苷酸和蛋白质序列及其基础的方法

    公开(公告)号：US06262025B1

    公开(公告)日：2001-07-17

    申请号：US08981392

    申请日：1998-04-07

    申请人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    发明人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Spyridon Artavanis-Tsakonas ,  Grace E. Gray

    IPC分类号： C07K1400

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00

    摘要： The present invention relates to nucleotide sequences of vertebrate Delta genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the vertebrate Delta protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Delta which comprise one or more domains of the Delta protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, domain amino-terminal to the DSL domain, transmembrane region, or one or more EGF-like repeats of a Delta protein, or any combination of the foregoing. Antibodies to Delta, its derivatives and analogs, are additionally provided. Methods of production of the Delta proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Delta genes, from Xenopus, chick, mouse, and human, are provided.

    摘要翻译： 本发明涉及脊椎动物Delta基因的核苷酸序列，及其编码的蛋白质的氨基酸序列以及衍生物（例如片段）及其类似物。 在具体实施方案中，脊椎动物Delta蛋白是人蛋白质。 本发明还涉及包含Delta蛋白的一个或多个结构域的Delta的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，DSL结构域的氨基末端， 跨膜区域，或Delta蛋白质的一种或多种EGF样重复序列或前述的任何组合。 额外提供了抗体对Delta，其衍生物和类似物。 还提供了通过重组方法生产Delta蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了来自爪蟾，小鸡，小鼠和人的孤立的Delta基因。

    Protein sequences of serrate gene products
    8.
    发明授权
    Protein sequences of serrate gene products 失效
    锯齿状基因产物的蛋白质序列

    公开(公告)号：US6004924A

    公开(公告)日：1999-12-21

    申请号：US611729

    申请日：1996-03-06

    申请人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Anna Mary Myat ,  Robert J. Fleming ,  Spyridon Artavanis-Tsakonas ,  Robert S. Mann ,  Grace E. Gray

    发明人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Anna Mary Myat ,  Robert J. Fleming ,  Spyridon Artavanis-Tsakonas ,  Robert S. Mann ,  Grace E. Gray

    IPC分类号： A61K38/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/465 ,  C07K14/705 ,  A01N37/18 ,  C07K14/00

    CPC分类号： C07K14/705 ,  C07K14/43504 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/463 ,  C07K14/465 ,  A61K38/00

    摘要： The present invention relates to nucleotide sequences of Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the Serrate protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Serrate which comprise one or more domains of the Serrate protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, cysteine rich domain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing. Antibodies to Serrate, its derivatives and analogs, are additionally provided. Methods of production of the Serrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Serrate genes, from Drosophila, chick, mouse, Xenopus and human, are provided.

    摘要翻译： 本发明涉及Serrate基因的核苷酸序列及其编码的蛋白质的氨基酸序列，以及衍生物（例如片段）及其类似物。 在一个具体实施方案中，所述丝氨酸蛋白是人蛋白质。 本发明还涉及含有一个或多个丝氨酸蛋白结构域的丝氨酸的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，富含半胱氨酸的结构域，跨膜区， 或一种或多种丝裂蛋白的EGF样重复体，或前述的任何组合。 还提供了对Serrate及其衍生物和类似物的抗体。 还提供了通过重组方法生产丝氨酸蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了从果蝇，小鸡，小鼠，非洲爪蟾和人的分离的Serrate基因。

    Antibodies to vertebrate serrate proteins and fragments
    10.
    发明授权
    Antibodies to vertebrate serrate proteins and fragments 失效
    脊椎动物对锯齿状蛋白和片段的抗体

    公开(公告)号：US06703489B1

    公开(公告)日：2004-03-09

    申请号：US09195524

    申请日：1998-11-19

    申请人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Anna Mary Myat ,  Robert J. Fleming ,  Spyridon Artavanis-Tsakonas ,  Robert S. Mann ,  Grace E. Gray

    发明人： David Ish-Horowicz ,  Domingos Manuel Pinto Henrique ,  Julian Hart Lewis ,  Anna Mary Myat ,  Robert J. Fleming ,  Spyridon Artavanis-Tsakonas ,  Robert S. Mann ,  Grace E. Gray

    IPC分类号： A61K3824

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/43504 ,  C07K14/43581 ,  C07K14/46 ,  C07K14/463 ,  C07K14/465

    摘要： The present invention relates to nucleotide sequences of Serrate genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the Serrate protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of Serrate which comprise one or more domains of the Serrate protein, including but not limited to the intracellular domain, extracellular domain, DSL domain, cysteine rich domain, transmembrane region, membrane-associated region, or one or more EGF-like repeats of a Serrate protein, or any combination of the foregoing. Antibodies to Serrate, its derivatives and analogs, are additionally provided. Methods of production of the Serrate proteins, derivatives and analogs, e.g., by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. In specific examples, isolated Serrate genes, from Drosophila, chick, mouse, Xenopus and human, are provided.

    摘要翻译： 本发明涉及Serrate基因的核苷酸序列及其编码的蛋白质的氨基酸序列，以及衍生物（例如片段）及其类似物。 在一个具体实施方案中，所述丝氨酸蛋白是人蛋白质。 本发明还涉及含有一个或多个丝氨酸蛋白结构域的丝氨酸的片段（及其衍生物和类似物），包括但不限于细胞内结构域，细胞外结构域，DSL结构域，富含半胱氨酸的结构域，跨膜区， 或一种或多种丝裂蛋白的EGF样重复体，或前述的任何组合。 还提供了对Serrate及其衍生物和类似物的抗体。 还提供了通过重组方法生产丝氨酸蛋白质，衍生物和类似物的方法。 提供了治疗和诊断方法和药物组合物。 在具体实例中，提供了从果蝇，小鸡，小鼠，非洲爪蟾和人的分离的Serrate基因。