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公开(公告)号：US5882671A
公开(公告)日：1999-03-16
申请号：US786170
申请日：1997-01-21
申请人： David Reed Helton , Mary Jeanne Kallman , James Allen Monn , Darryle Darwin Schoepp , Joseph Patrick Tizzano
发明人： David Reed Helton , Mary Jeanne Kallman , James Allen Monn , Darryle Darwin Schoepp , Joseph Patrick Tizzano
IPC分类号： A61K45/00 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/215 , A61P25/20 , A61P43/00 , C07C62/38 , C07C229/50 , C07D235/02 , A61K9/64
CPC分类号： C07D235/02 , A61K31/00 , A61K31/198 , A61K31/215 , C07C229/50 , C07C62/38 , C07C2102/18 , Y10S514/811 , Y10S514/82
摘要： The present invention provides a method of treating anxiety and related disorders using an agonist which acts at negatively coupled cAMP-linked metabotropic glutamate receptors.
摘要翻译： 本发明提供使用以负相关联的cAMP连接的代谢型谷氨酸受体作用的激动剂来治疗焦虑和相关疾病的方法。
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公开(公告)号：US06800651B2
公开(公告)日：2004-10-05
申请号：US10182961
申请日：2002-11-20
申请人： Darrell Stephen Coleman , Gunnar Erik Jagdmann , Kirk Willis Johnson , Michael Parvin Johnson , Thomas Hallett Large , James Allen Monn , Darryle Darwin Schoepp , Thomas Charles Britton , Steven Scott Henry , Joseph Patrick Tizzano
发明人： Darrell Stephen Coleman , Gunnar Erik Jagdmann , Kirk Willis Johnson , Michael Parvin Johnson , Thomas Hallett Large , James Allen Monn , Darryle Darwin Schoepp , Thomas Charles Britton , Steven Scott Henry , Joseph Patrick Tizzano
IPC分类号： A01K3144
CPC分类号： C07D213/40 , C07D213/30 , C07D213/38 , C07D213/42 , C07D213/61 , C07D213/643 , C07D213/76 , C07D213/89 , C07D405/12 , C07D409/12
摘要： The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.
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公开(公告)号：US5843997A
公开(公告)日：1998-12-01
申请号：US626447
申请日：1996-04-02
IPC分类号： C07D249/08 , A61K31/19 , A61K31/215 , A61K31/335 , A61K31/34 , A61K31/343 , A61K31/357 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/41 , A61K31/42 , A61K31/435 , A61K31/4402 , A61K31/4418 , A61K31/445 , A61K31/451 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5377 , A61P1/08 , A61P9/10 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07C229/24 , C07C229/26 , C07C233/00 , C07C311/13 , C07C317/48 , C07C323/50 , C07C323/58 , C07D207/12 , C07D207/16 , C07D207/28 , C07D209/52 , C07D211/76 , C07D213/54 , C07D213/61 , C07D231/18 , C07D239/38 , C07D249/10 , C07D249/12 , C07D257/04 , C07D261/10 , C07D261/12 , C07D265/02 , C07D307/79 , C07D307/91 , C07D317/60 , C07D317/64 , C07D319/18 , C07D333/52 , C07D403/04 , C07D453/06 , C07C229/36
CPC分类号： C07D257/04 , C07C229/24 , C07C323/58 , C07D207/28 , C07D213/54 , C07D239/38 , C07D249/12 , C07D307/91 , C07D317/64 , C07C2101/08 , C07C2102/08 , C07C2102/10 , C07C2103/18
摘要： The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods for the preparation of the novel compounds.
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公开(公告)号：US5739164A
公开(公告)日：1998-04-14
申请号：US713624
申请日：1996-09-13
申请人： Jesus Ezquerra Carrera , Almudena Rubio Esteban , Andre Mann , Angele Schoenfelder , Darryle Darwin Schoepp , Concepcion Pedregal Tercero , Camille-Georges Wermuth
发明人： Jesus Ezquerra Carrera , Almudena Rubio Esteban , Andre Mann , Angele Schoenfelder , Darryle Darwin Schoepp , Concepcion Pedregal Tercero , Camille-Georges Wermuth
IPC分类号： A61K31/00 , A61K31/19 , A61K31/195 , A61K31/20 , A61K31/215 , A61K31/38 , A61K31/41 , A61P1/08 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07C229/36 , C07D257/04 , C07D333/24 , C07D409/06
CPC分类号： C07D257/04 , C07C229/36
摘要： Disclosed herein is a method of treating a disease of the central nervous system with a compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is --CO.sub.2 H or tetrazolyl, Y is --CH.dbd.CH--, and Z is (i) phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, (ii) --CHR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are each phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, (iii) .dbd.CR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 are each phenyl, naphthyl or thienyl, said phenyl, naphthyl and thienyl being optionally substituted, or (iv) ##STR2## where r is 0 or 1 to 3 and the phenyl rings are optionally substituted; provided that when Z is phenyl and m is 1, p is 1; and salts and esters thereof.
摘要翻译： 本文公开了一种用式“IMAGE”的化合物治疗中枢神经系统疾病的方法，其中m为0,1或2，n和q各自为0或1至5，p为0或1 X是-CO 2 H或四唑基，Y是-CH = CH-，Z是（i）苯基，萘基或噻吩基，所述苯基，萘基和噻吩基任选被取代，（ii）-CHR 1 R 2，其中R 1和R 2各自是苯基 萘基或噻吩基，所述苯基，萘基和噻吩基任选被取代，（iii）= CR1R2，其中R1和R2各自为苯基，萘基或噻吩基，所述苯基，萘基和噻吩基任选被取代，或（iv） r为0或1至3，苯环任选被取代; 条件是当Z为苯基且m为1时，p为1; 及其盐和酯。
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