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公开(公告)号:US20050136073A1
公开(公告)日:2005-06-23
申请号:US11053290
申请日:2005-02-08
申请人: Derek O'Hagan , Gary Nest , Gary Ott , Manmohan Singh
发明人: Derek O'Hagan , Gary Nest , Gary Ott , Manmohan Singh
IPC分类号: A61K9/00 , A61K9/107 , A61K9/16 , A61K39/21 , A61K39/29 , A61K39/39 , A61P37/04 , A61K39/12 , A61K9/50
CPC分类号: A61K39/39 , A61K9/1075 , A61K9/1647 , A61K39/12 , A61K39/21 , A61K39/29 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/6093 , C12N2740/16134 , C12N2770/24234 , Y02A50/412
摘要: Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.