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公开(公告)号：US3974289A
公开(公告)日：1976-08-10
申请号：US461267
申请日：1974-04-15
IPC分类号： C07D311/56 , A61K31/37 , C07D311/50 , C07D311/54 , C07D311/92
CPC分类号： C07D311/54 , A61K31/37 , C07D311/50
摘要： Pharmaceutical compositions for the treatment of allergies are produced using coumarin derivatives as the active agent. Certain of these compounds and their salts are novel.
摘要翻译： 使用香豆素衍生物作为活性剂制备用于治疗过敏症的药物组合物。 这些化合物及其盐中的某些是新颖的。
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2.发明授权Isocarbostyril-3-carboxylic acid derivatives for the prophylaxis of asthma, hayfever and rhinitis 失效异卡波斯特尔-3-羧酸衍生物，用于预防哮喘，草药和鼻炎
公开(公告)号：US4036964A
公开(公告)日：1977-07-19
申请号：US644132
申请日：1975-12-24
IPC分类号： C07D217/26 , A61K31/47
CPC分类号： C07D217/26 , Y10S514/826
摘要： 3-Carboxyisocoumarins, 2-thiaisocoumarins and related isocarbostyrils are useful anti-allergic agents. Several of these compounds are novel, and a process for their preparation is provided.
摘要翻译： 3-羧基异香豆素，2-硫代异香豆素和相关的异卡波姆斯特尔是有用的抗过敏剂。 这些化合物中的几种是新颖的，并且提供了其制备方法。
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公开(公告)号：US3983156A
公开(公告)日：1976-09-28
申请号：US454922
申请日：1974-03-26
IPC分类号： C07C205/45 , A61K31/24 , C07C13/465 , C07C67/00 , C07C201/00 , C07C201/08 , C07C205/54 , C07D307/88 , C07D307/89 , C07C79/46
CPC分类号： C07D307/88 , C07C205/54 , C07D307/89 , Y10S514/826
摘要： Substituted .omega.-nitroacetophenones and their preparation and intermediates therefor are described together with pharmaceutical compositions containing such nitroacetophenones for the prophylaxis and treatment of diseases associated with allergic or immunological reactions such as asthma, hayfever and rhinitis.
摘要翻译： 与含有这种硝基苯乙酮的药物组合物一起描述取代的ω-硝基苯乙烯及其制备物和中间体，用于预防和治疗与过敏或免疫反应如哮喘，过敏性和鼻炎相关的疾病。
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公开(公告)号：US4032544A
公开(公告)日：1977-06-28
申请号：US700512
申请日：1976-06-28
IPC分类号： C07C49/67 , C07C65/05 , C07D311/42 , C07D311/06
CPC分类号： C07C247/00 , C07C49/67 , C07C65/05 , C07C2103/16 , Y10S514/826
摘要： Compounds of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof or hydrates thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, lower alkyl or lower alkoxy, or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4, taken together with the carbon atoms to which they are joined complete a substituted or unsubstituted carbocyclic ring, and X is an oxygen atom, provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all simultaneously hydrogen, are useful for treating allergic conditions in humans.The compounds may be prepared by reacting a suitably substituted benzene derivative with an activated carbonyl group having a carbanion of the formula NC-CH-R, wherein R is a carboxylic acid ester group, and thereafter, if desired, converting the compound into a salt.
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5.发明授权Tetrahydrocarbostyril derivatives for the prophylaxis of asthma, hayfever and rhinitis 失效用于预防哮喘，干草和鼻炎的四氢卡波吡啶衍生物
公开(公告)号：US4006237A
公开(公告)日：1977-02-01
申请号：US579416
申请日：1975-05-21
IPC分类号： C07D215/22 , C07D221/04 , A61K31/47
CPC分类号： C07D215/22 , C07D221/04 , Y10S514/826
摘要： Pharmaceutical compositions having anti-allergy activity in which the active anti-allergy agents are certain 3-nitro-.alpha.-pyridones and their pharmaceutically acceptable salts formulated in one or more pharmaceutically acceptable carriers.
摘要翻译： 具有抗过敏活性的药物组合物，其中活性抗过敏剂是一种或多种药学上可接受的载体中配制的某些3-硝基-α-吡啶酮及其药学上可接受的盐。
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公开(公告)号：US3962445A
公开(公告)日：1976-06-08
申请号：US545100
申请日：1975-01-29
IPC分类号： A61K31/47
CPC分类号： Y10S514/826
摘要： A class of 4-hydroxy-3-nitroearbostyril derivatives are useful in the inhibition of certain types of antigen antibody reactions.
摘要翻译： 一类4-羟基-3-硝基甲苯吡啶衍生物可用于抑制某些类型的抗原抗体反应。
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公开(公告)号：US4059704A
公开(公告)日：1977-11-22
申请号：US672753
申请日：1976-04-01
IPC分类号： C07D405/04 , A61K31/41 , C07D257/04
CPC分类号： C07D405/04 , Y10S514/826
摘要： A novel class of 3-tetrazole coumarins have anti-allergic activity. They are prepared by the action of ammonium azide on 3-cyano compounds.
摘要翻译： 一类新型的3-四唑香豆素具有抗过敏活性。 它们通过叠氮化铵对3-氰基化合物的作用制备。
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公开(公告)号：US3975535A
公开(公告)日：1976-08-17
申请号：US510803
申请日：1974-09-30
IPC分类号： C07D217/26 , C07D311/76 , C07D335/06 , A61K31/335
CPC分类号： C07D335/06 , C07D217/26 , C07D311/76 , Y10S514/826
摘要： 3-Carboxyisocoumarins, 2-thiaisocoumarins and related isocarbostyrils are useful anti-allergic agents. Several of these compounds are novel, and a process for their preparation is provided.
摘要翻译： 3-羧基异香豆素，2-硫代异香豆素和相关的异卡波姆斯特尔是有用的抗过敏剂。 这些化合物中的几种是新颖的，并且提供了其制备方法。
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公开(公告)号：US4065457A
公开(公告)日：1977-12-27
申请号：US715501
申请日：1976-08-18
IPC分类号： C07D215/22 , C07D215/26 , C07D221/10
CPC分类号： C07D215/22 , C07D215/26 , C07D221/10
摘要： A class of 4-hydroxy-3-nitrocarbostyril derivatives are useful in the inhibition of certain types of antigen antibody reactions.
摘要翻译： 一类4-羟基-3-硝基喹诺酮衍生物可用于抑制某些类型的抗原抗体反应。
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公开(公告)号：US4031099A
公开(公告)日：1977-06-21
申请号：US512949
申请日：1974-10-07
IPC分类号： C07D215/22 , C07D215/26 , C07D215/38 , C07D215/40 , C07D221/04 , C07D401/04 , A61K31/47
CPC分类号： C07D215/22 , C07D215/26 , C07D215/38 , C07D215/40 , C07D221/04
摘要： A class of 4-hydroxy-3-nitro-.alpha.-pyridones have anti-allergic activity.
摘要翻译： 一类4-羟基-3-硝基-α-吡啶酮具有抗过敏活性。
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