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公开(公告)号：US11085062B2
公开(公告)日：2021-08-10
申请号：US16470807
申请日：2017-12-29
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： Shih-Chong Tsai , Chun-Chung Lee , Meng-Sheng Lee , Ching-Yao Chen , Shih-Hsien Chuang , Yi-Jen Chen , Win-Yin Wei
Abstract: A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein-payload conjugates, as well as the conjugates produced thereby.
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公开(公告)号：US20170369525A1
公开(公告)日：2017-12-28
申请号：US15541020
申请日：2015-12-31
Applicant: Development Center for Biotechnology , DCB-USA LLC
Inventor： Chao-Pin Lee , Cheng-Chou Yu , Chi-Huey Wong , Chuan-Lung Hsu , Chun-Chung Lee , Shih-Hsien Chuang , Ta-Tung Yuan , Yi-Jen Chen , Yu-Chin Nieh
IPC: C07K1/107 , C07K1/08 , A61K39/395 , C07K16/18 , A61K47/68
CPC classification number: C07K1/1077 , A61K39/395 , A61K47/6803 , A61K47/6855 , A61K47/6889 , A61K49/0043 , A61K49/0058 , C07K1/08 , C07K16/18
Abstract: A method for specific linkage to a glycoprotein includes obtaining a glycoprotein having a monoglycan or diglycan attached thereto; producing a reactive functional group on a sugar unit on the glycoprotein; and coupling a linker or a payload to the reactive functional group on the glycoprotein.
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公开(公告)号：US10947316B2
公开(公告)日：2021-03-16
申请号：US16010251
申请日：2018-06-15
Applicant: Development Center for Biotechnology
Inventor： Chao-Pin Lee , Shih-Hsien Chuang , Chuan-Lung Hsu , Yi-Jen Chen , Yu-Chin Nieh , Win-Yin Wei , Chia-Cheng Wu
IPC: A61P35/00 , A61K47/68 , A61K49/00 , G01N33/574 , A61K47/64 , A61K47/65 , A61K31/337 , A61K31/5365 , C07K16/30 , A61K39/395 , C07K16/28
Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.
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公开(公告)号：US20190106507A1
公开(公告)日：2019-04-11
申请号：US16010251
申请日：2018-06-15
Applicant: Development Center for Biotechnology
Inventor： Chao-Pin Lee , Shih-Hsien Chuang , Chuan-Lung Hsu , Yi-Jen Chen , Yu-Chin Nieh , Win-Yin Wei , Chia-Cheng Wu
Abstract: An immunoconjugate includes an anti-Globo H antibody, or a binding fragment thereof, and a therapeutic agent or a label, having the formula: Ab−(L−D)m, wherein Ab is the anti-Globo H antibody or the binding fragment thereof, L is a linker or a direct bond, D is the therapeutic agent or the label, and m is an integer from 1 to 8. The antibody may be a monoclonal antibody, which may be a humanized antibody. A method for treating a cancer includes administering to a subject in need of such treatment a pharmaceutically effective amount of an immunoconjugate containing an antibody against Globo H, or a binding fragment thereof, and a therapeutic agent covalently conjugated with the antibody.
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