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    Hepatic-directed compounds and reagents for preparation thereof
    2.
    发明授权
    Hepatic-directed compounds and reagents for preparation thereof 失效
    肝取向化合物及其制备试剂

    公开(公告)号：US5886143A

    公开(公告)日：1999-03-23

    申请号：US351651

    申请日：1994-12-07

    申请人： Louis J. Theodore ,  Donald B. Axworthy ,  John M. Reno

    发明人： Louis J. Theodore ,  Donald B. Axworthy ,  John M. Reno

    IPC分类号： A61K31/7028 ,  A61K47/48 ,  A61K51/08 ,  A61P1/16 ,  C07H15/04 ,  C07H15/14 ,  C07H15/26 ,  A61K38/14 ,  C07H15/02 ,  C07K9/00

    CPC分类号： B82Y5/00 ,  A61K47/4873 ,  A61K51/0465 ,  C07H15/04 ,  C07H15/14 ,  A61K2121/00

    摘要： Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are discussed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Reagents useful in the preparation of hepatic-directed compounds include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.

    摘要翻译： 讨论了肝取向化合物，可用于制备这些化合物的试剂和相关方法和组合物。 肝取向化合物通过代谢机制进行处理，其代谢机制通常在程度上或种类上不同于未被引导的化合物所遇到的代谢机制。 可用于制备肝取向化合物的试剂包括以反复分支构型连接的多个己糖残基为特征的己糖簇。 在一个实施方案中，己糖簇包含至少四个己糖残基，其中每个分支具有两个分支。 在另一个实施方案中，己糖簇包含至少九个己糖残基，其中每个分支具有三个分支。

    Methods of using hepatic-directed compounds in pretargeting strategies
    9.
    发明授权
    Methods of using hepatic-directed compounds in pretargeting strategies 失效
    使用肝取向化合物预先靶向策略的方法

    公开(公告)号：US5985826A

    公开(公告)日：1999-11-16

    申请号：US808024

    申请日：1997-03-03

    申请人： Louis J. Theodore ,  Donald B. Axworthy ,  John M. Reno

    发明人： Louis J. Theodore ,  Donald B. Axworthy ,  John M. Reno

    IPC分类号： A61K31/7028 ,  A61K47/48 ,  A61K51/08 ,  A61P1/16 ,  C07H15/04 ,  C07H15/14 ,  C07H15/26 ,  A61K31/70 ,  A61K31/715 ,  A61K31/73 ,  A61K38/14

    CPC分类号： B82Y5/00 ,  A61K47/4873 ,  A61K51/0465 ,  C07H15/04 ,  C07H15/14 ,  A61K2121/00

    摘要： Hepatic-directed compounds, reagents useful in making such compounds and associated methods and compositions are disclosed. Hepatic-directed compounds are processed by metabolic mechanisms, which generally differ in degree or in kind from the metabolic mechanisms encountered by compounds which are not so directed. Hepatic-directed compounds useful in the methods disclosed include a hexose cluster characterized by multiple hexose residues connected in an iteratively branched configuration. In one embodiment, the hexose cluster comprises at least four hexose residues with each branch of the configuration having two prongs. In another embodiment, the hexose cluster comprises at least nine hexose residues with each branch of the configuration having three prongs.

    摘要翻译： 公开了肝取向化合物，可用于制备这些化合物的试剂和相关方法和组合物。 肝取向化合物通过代谢机制进行处理，其代谢机制通常在程度上或种类上不同于未被引导的化合物所遇到的代谢机制。 可用于所公开方法的肝取向化合物包括以多个己糖残基以反复分支构型连接的特征的己糖簇。 在一个实施方案中，己糖簇包含至少四个己糖残基，其中每个分支具有两个分支。 在另一个实施方案中，己糖簇包含至少九个己糖残基，其中每个分支具有三个分支。