公开(公告)号：US10278819B2

公开(公告)日：2019-05-07

申请号：US15167760

申请日：2016-05-27

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

公开(公告)号：US11166817B2

公开(公告)日：2021-11-09

申请号：US16358480

申请日：2019-03-19

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

公开(公告)号：US20160346084A1

公开(公告)日：2016-12-01

申请号：US15167760

申请日：2016-05-27

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2250/0014

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.

Abstract translation: 本文公开了用于改善二尖瓣小叶的缩小以减少或消除二尖瓣反流的装置。 该装置可用于进行二尖瓣瓣膜成形术，或用作经导管假体心脏瓣膜的对接站。 装置的各种实施例被配置用于经皮的，在一些情况下被配置为经血管递送。 还公开了用于将装置路由到二尖瓣的输送系统，包括导管，球囊和/或机械膨胀系统。 装置本身包括至少一个组织穿透构件。 递送方法包括通过至少一个组织穿透构件将装置部分地嵌入二尖瓣环中。 组织穿透构件可以以同时或几乎同时的方式嵌入组织中。 在嵌入时，装置采用各种膨胀和/或收缩特征来调节二尖瓣直径。 调整可能会继续，直到传单完全适应，并减少或消除二尖瓣反流问题。

公开(公告)号：US12245940B2

公开(公告)日：2025-03-11

申请号：US17521571

申请日：2021-11-08

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.

公开(公告)号：US20220061990A1

公开(公告)日：2022-03-03

申请号：US17521571

申请日：2021-11-08

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.

公开(公告)号：US20240173034A1

公开(公告)日：2024-05-30

申请号：US18431809

申请日：2024-02-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Harvey H. Chen ,  Manouchehr A. Miraki ,  Rodolfo Rodriguez ,  Erin E. Castioni ,  Maria L. Saravia ,  Stephen Epstein ,  Luke Anthony Zanetti ,  Ashley Nicolette Hinga (formerly Keffer) ,  Stephen Cournane ,  Felino V. Cortez, JR. ,  Nancy Ling Chung ,  Daniel Yasevac ,  Andrew Ryan ,  Slava Arabagi ,  Jaime L. Baluyot ,  Sooji Van Echten ,  Da-Yu Chang ,  John Richard Carpenter ,  Sai Prasad Uppalapati ,  Pui Tong Ho ,  Jason Thai Le ,  Adam J. Yestrepsky

IPC: A61B17/122 ,  A61B17/00 ,  A61B17/128

CPC classification number: A61B17/1227 ,  A61B17/00234 ,  A61B17/1285 ,  A61B2017/00243

Abstract: Systems, apparatuses, and methods disclosed herein may be directed to clips for medical implementation, including clips for a portion of a heart. The clips may be configured to close the portion of the heart, to reduce blood flow therethrough as well as passage of clots or other undesired materials. In examples, the clips may be configured to close the left atrial appendage (LAA). The closure of the LAA may reduce the possibility of stroke or other maladies stemming from fluid flow with the LAA. In examples, the clips may be positioned exterior of the LAA, to extend over an outer surface of the LAA for closure.

公开(公告)号：US20220287836A1

公开(公告)日：2022-09-15

申请号：US17681660

申请日：2022-02-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Robert Landon ,  Taylor Jacob Scheinblum ,  Matthew Michael Becerra ,  Alexander H. Cooper ,  Jesse Robert Edwards ,  Hieu Minh Luong ,  David L. Hauser ,  Pui Tong Ho

IPC: A61F2/24 ,  A61F2/95

Abstract: Devices, systems and methods are described herein to provide improved treatment of a tricuspid valve. Such treatment may include tricuspid valve replacement, which may include providing a prosthetic tricuspid valve within the tricuspid valve annulus. Delivery systems for delivering the prosthetic tricuspid valve to the tricuspid valve annulus are disclosed herein. Treatment may also include repair of the tricuspid valve.

公开(公告)号：US20190209322A1

公开(公告)日：2019-07-11

申请号：US16358480

申请日：2019-03-19

Applicant: Edwards Lifesciences Corporation

Inventor： David M. Taylor ,  Tri D. Tran ,  Sean Chow ,  David L. Hauser ,  Pui Tong Ho ,  Alexander H. Cooper

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2250/0014

Abstract: Disclosed herein are devices for improving coaption of the mitral valve leaflets to reduce or eliminate mitral valve regurgitation. The devices may be used to perform mitral valve annuloplasty, or to serve as a docking station for a transcatheter prosthetic heart valve. The various embodiments of devices are configured for percutaneous and, in some cases, transvascular delivery. Delivery systems useful for routing the devices to the mitral valve are also disclosed, including catheters, balloons and/or mechanical expansion systems. The devices themselves include at least one tissue penetrating member. Methods of delivery include partially embedding the devices in the mitral valve annulus via at least one tissue penetrating member. Tissue penetrating members may be embedded into the tissue in a simultaneous or a nearly simultaneous fashion. Upon embedding, the devices employ various expansion and/or contraction features to adjust the mitral valve diameter. Adjustments may continue until the leaflets fully coapt and the problem of mitral regurgitation is reduced or eliminated.