公开(公告)号：US10675836B2

公开(公告)日：2020-06-09

申请号：US16352966

申请日：2019-03-14

Applicant: EMD Millipore Corporation

Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

IPC: B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B27/34 ,  B32B27/40 ,  B01L3/00 ,  B65D65/40 ,  B65D75/58 ,  G01M3/32

Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

公开(公告)号：US20170368790A1

公开(公告)日：2017-12-28

申请号：US15544644

申请日：2016-03-22

Applicant: EMD Millipore Corporation

Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

IPC: B32B5/02 ,  B65D75/58 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B27/40 ,  G01M3/32 ,  B65D65/40 ,  B01L3/00

CPC classification number: B32B5/024 ,  B01L3/508 ,  B01L2300/0887 ,  B01L2300/16 ,  B32B5/02 ,  B32B5/022 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B27/34 ,  B32B27/40 ,  B32B2262/0253 ,  B32B2262/0261 ,  B32B2262/0269 ,  B32B2262/0276 ,  B32B2262/103 ,  B32B2262/106 ,  B32B2307/554 ,  B32B2307/7242 ,  B32B2439/40 ,  B32B2439/80 ,  B65D65/40 ,  B65D75/58 ,  B65D2275/00 ,  G01M3/3272

Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

公开(公告)号：US10272639B2

公开(公告)日：2019-04-30

申请号：US15544644

申请日：2016-03-22

Applicant: EMD Millipore Corporation

Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

IPC: B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B27/34 ,  B32B27/40 ,  B01L3/00 ,  B65D65/40 ,  B65D75/58 ,  G01M3/32

Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

公开(公告)号：US20190210321A1

公开(公告)日：2019-07-11

申请号：US16352966

申请日：2019-03-14

Applicant: EMD Millipore Corporation

Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

IPC: B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B01L3/00 ,  B32B27/40 ,  B65D75/58 ,  B65D65/40 ,  G01M3/32 ,  B32B27/34

Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

公开(公告)号：US11110684B2

公开(公告)日：2021-09-07

申请号：US16867288

申请日：2020-05-05

Applicant: EMD Millipore Corporation

Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

IPC: B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B27/34 ,  B32B27/40 ,  B01L3/00 ,  B65D65/40 ,  B65D75/58 ,  G01M3/32

Abstract: A multilayered film for biocontainers, an abrasion-resistant substrate attached to the interior or the exterior side of the film wherein the substrate is one of a polymeric woven fibrous material or a polymeric non-woven fibrous material, a woven fibrous material or a non-woven fibrous material having metal fibers, a woven fibrous material or a non-woven fibrous material having glass fibers, or a woven fibrous material or a non-woven fibrous material having carbon fibers; a polymer backing to attach the substrate to the film, including one of polyolefins, polyurethanes and nylons; an outer protective layer disposed on the outside of the substrate to encapsulate the substrate; and a gas impermeable layer that includes ethylene vinyl alcohol disposed intermediate to the substrate and the outer protective layer.

公开(公告)号：US20200262175A1

公开(公告)日：2020-08-20

申请号：US16867288

申请日：2020-05-05

Applicant: EMD Millipore Corporation

Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

IPC: B32B5/02 ,  G01M3/32 ,  B65D75/58 ,  B65D65/40 ,  B01L3/00 ,  B32B27/40 ,  B32B27/34 ,  B32B27/32 ,  B32B27/12 ,  B32B27/08

Abstract: A material for biocontainers including a multilayered film, the multilayered film having an interior and exterior side, an abrasion-resistant substrate attached to the interior or the exterior side of the film wherein the substrate comprises a polymeric woven fibrous material or a polymeric non-woven fibrous material, a woven fibrous material or a non-woven fibrous material comprising metal fibers, a woven fibrous material or a non-woven fibrous material comprising glass fibers, or a woven fibrous material or a non-woven fibrous material comprising carbon fibers; a polymer backing to attach the substrate to the film, the polymer backing comprising one of polyolefins, polyurethanes and nylons; an outer protective layer disposed on the outside of the substrate to encapsulate the substrate; and a gas impermeable layer that includes ethylene vinyl alcohol disposed intermediate to the substrate and the outer protective layer.