公开(公告)号：US07208506B2

公开(公告)日：2007-04-24

申请号：US11477641

申请日：2006-06-29

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

IPC分类号： A61K31/38 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44

CPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  C07D213/59 ,  C07D333/24

摘要： The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3 3定义为其药学上可接受的盐，对映体形式 ，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防诸如癌症等疾病中的用途。

公开(公告)号：US20070010564A1

公开(公告)日：2007-01-11

申请号：US11477641

申请日：2006-06-29

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Thomas von Hirschheydt ,  Timothy Woodcock

IPC分类号： A61K31/44 ,  A61K31/381 ,  C07D333/22 ,  C07D213/56

CPC分类号： A61K31/38 ,  A61K31/381 ,  A61K31/44 ,  C07D213/59 ,  C07D333/24

摘要： The present invention relates to compounds of formula I wherein R1, R2 and R3 are defined herein, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

公开(公告)号：US20060270874A1

公开(公告)日：2006-11-30

申请号：US11414042

申请日：2006-04-28

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Matthias Koerner ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Timothy Woodcock

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Matthias Koerner ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Timothy Woodcock

IPC分类号： C07C311/45

CPC分类号： C07C311/51

摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备，以及这些化合物在 控制或预防癌症等疾病。

公开(公告)号：US07208526B2

公开(公告)日：2007-04-24

申请号：US11414042

申请日：2006-04-28

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Matthias Koerner ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Timothy Woodcock

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Matthias Koerner ,  Manfred Kubbies ,  Raymond Lau ,  Ulrike Reiff ,  Georg Tiefenthaler ,  Wolfgang von der Saal ,  Timothy Woodcock

IPC分类号： A61K31/18 ,  C07C311/51

CPC分类号： C07C311/51

摘要： The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明涉及式I化合物：其药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备，以及这些化合物在 控制或预防癌症等疾病。

公开(公告)号：US20100292247A1

公开(公告)日：2010-11-18

申请号：US12377911

申请日：2007-10-24

申请人： Frederick Brookfield ,  Jonathan Gridley ,  Lothar Kling ,  Michael Prime ,  Ulrike Reiff ,  Wolfgang von der Saal ,  Thomas von Hirschheydt

发明人： Frederick Brookfield ,  Jonathan Gridley ,  Lothar Kling ,  Michael Prime ,  Ulrike Reiff ,  Wolfgang von der Saal ,  Thomas von Hirschheydt

IPC分类号： A61K31/496 ,  C07D401/14 ,  C07D401/04 ,  C07D491/113 ,  A61K31/438 ,  A61P35/00

CPC分类号： C07D295/04

摘要： Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在对照中的用途 或预防癌症等疾病。

公开(公告)号：US07939532B2

公开(公告)日：2011-05-10

申请号：US12377911

申请日：2006-10-24

申请人： Frederick Brookfield ,  Jonathan Gridley ,  Lothar Kling ,  Michael Prime ,  Ulrike Reiff ,  Wolfgang Von Der Saal ,  Thomas Von Hirschheydt

发明人： Frederick Brookfield ,  Jonathan Gridley ,  Lothar Kling ,  Michael Prime ,  Ulrike Reiff ,  Wolfgang Von Der Saal ,  Thomas Von Hirschheydt

IPC分类号： A61K31/438 ,  A61K31/4545 ,  A61K31/496 ,  C07D213/74 ,  C07D401/12 ,  C07D491/13 ,  A61P35/00

CPC分类号： C07D295/04

摘要： Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在对照中的用途 或预防癌症等疾病。

公开(公告)号：US07879884B2

公开(公告)日：2011-02-01

申请号：US12599699

申请日：2008-05-14

申请人： Frederick Brookfield ,  Lothar Kling ,  Ulrike Reiff ,  Wolfgang Von der Saal ,  Thomas Von Hirschheydt

发明人： Frederick Brookfield ,  Lothar Kling ,  Ulrike Reiff ,  Wolfgang Von der Saal ,  Thomas Von Hirschheydt

IPC分类号： A61K31/44 ,  C07D213/00

CPC分类号： C07D213/71

摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。

公开(公告)号：US20100256200A1

公开(公告)日：2010-10-07

申请号：US12599699

申请日：2008-05-14

申请人： Frederick Brookfield ,  Lothar Kling ,  Ulrike Reiff ,  Wolfgang Von der Saal ,  Thomas Von Hirschheydt

发明人： Frederick Brookfield ,  Lothar Kling ,  Ulrike Reiff ,  Wolfgang Von der Saal ,  Thomas Von Hirschheydt

IPC分类号： A61K31/4418 ,  C07D213/71 ,  A61P35/00

CPC分类号： C07D213/71

摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。

公开(公告)号：US20100120840A1

公开(公告)日：2010-05-13

申请号：US11989272

申请日：2006-07-28

申请人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Konrad Honold ,  Raymond Lau ,  Stefan Scheiblich

发明人： Edward Boyd ,  Frederick Brookfield ,  Jonathan Gridley ,  Konrad Honold ,  Raymond Lau ,  Stefan Scheiblich

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P35/00 ,  A61P37/02

CPC分类号： C07D471/04

摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

公开(公告)号：US07226923B2

公开(公告)日：2007-06-05

申请号：US11233311

申请日：2005-09-23

申请人： Edward Boyd ,  Frederick Brookfield ,  Guy Georges ,  Bernhard Goller ,  Sabine Huensch ,  Petra Rueger ,  Matthias Rueth ,  Stefan Scheiblich ,  Christine Schuell ,  Wolfgang von der Saal ,  Justin Warne ,  Stefan Weigand

发明人： Edward Boyd ,  Frederick Brookfield ,  Guy Georges ,  Bernhard Goller ,  Sabine Huensch ,  Petra Rueger ,  Matthias Rueth ,  Stefan Scheiblich ,  Christine Schuell ,  Wolfgang von der Saal ,  Justin Warne ,  Stefan Weigand

IPC分类号： C07D403/12 ,  C07D403/14 ,  A61K31/502

CPC分类号： C07D403/12

摘要： Compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates are disclosed. Also disclosed are methods for the preparation of the above-mentioned compounds, pharmaceutical compositions containing them, as well as the use of the above-mentioned compounds in the treatment, control or prevention of illnesses such as cancer.

摘要翻译： 公开了式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体。 还公开了制备上述化合物的方法，含有它们的药物组合物，以及上述化合物在治疗，控制或预防诸如癌症等疾病中的用途。