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    Compounds Having Crth2 Antagonist Activity
    10.
    发明申请
    Compounds Having Crth2 Antagonist Activity 审中-公开

    公开(公告)号：US20070232681A1

    公开(公告)日：2007-10-04

    申请号：US10573670

    申请日：2004-10-13

    申请人： David Middlemiss ,  Mark Ashton ,  Edward Boyd ,  Frederick Brookfield ,  Richard Armer ,  Eric Pettipher

    发明人： David Middlemiss ,  Mark Ashton ,  Edward Boyd ,  Frederick Brookfield ,  Richard Armer ,  Eric Pettipher

    IPC分类号： A61K31/40 ,  A61K31/405 ,  C07D209/04 ,  C07D209/34

    CPC分类号： C04B35/632 ,  C07D209/30 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： Compounds of general formula (I): wherein R1, R2, R3 and R4 are independently hydrogen, halo, C1-C6 alkyl, —O(C1-C6 alkyl), —CON(R9)2, —SOR9, —SO2R9, —SO2N(R9)2, —N(R9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; each R9 is independently hydrogen or C1-C6 alkyl; R5 and R6 are each independently hydrogen, or C1-C6 alkyl or together with the carbon atom to which they are attached form a C3-C7 cycloalkyl group; R7 is hydrogen or C1-C6 alkyl n is 1 or 2; X is a bond or, when n is 2, X may also be a NR9 group; wherein R9 is as defined above; when X is a bond R8 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, biphenyl or a 9-14 membered bicyclic or tricyclic heteroaryl group; when X is a NR9 group R8 may additionally be phenyl, naphthyl or a 5-7 membered heteroaromatic ring; and the R8 group is optionally substituted with one or more substituents selected from halo, C1-C6 alkyl, —O(C1-C6)alkyl, aryl, —O-aryl, heteroaryl, —O-heteroaryl, —CON(R9)2, —SOR9, —SO2R9, SO2N(9)2, —N(9)2, —NR9COR9, —CO2R9, —COR9, —SR9, —OH, —NO2 or —CN; wherein R9 is as defined above; and their pharmaceutically acceptable salts, hydrates, solvates, complexes and prodrugs are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.