公开(公告)号：US20230291163A1

公开(公告)日：2023-09-14

申请号：US18309870

申请日：2023-05-01

Applicant: Emad Eskandar

Inventor： Emad N. Eskandar ,  James Joseph Cohen

IPC: H01S1/04 ,  H01S4/00 ,  H01S1/02 ,  H01S1/00 ,  A61B90/00 ,  A61B18/18 ,  A61N5/04 ,  H01S1/06

CPC classification number: H01S1/04 ,  H01S4/00 ,  H01S1/02 ,  H01S1/005 ,  A61B90/36 ,  A61B18/1815 ,  A61N5/045 ,  H01S1/06 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2018/0016

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

公开(公告)号：US11641087B2

公开(公告)日：2023-05-02

申请号：US17148120

申请日：2021-01-13

Applicant: Emad Eskandar

Inventor： Emad N. Eskandar ,  James Joseph Cohen

IPC: H01S1/04 ,  H01S4/00 ,  H01S1/02 ,  H01S1/00 ,  A61B90/00 ,  A61B18/18 ,  A61N5/04 ,  H01S1/06 ,  A61B18/00 ,  A61N5/02

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

公开(公告)号：US11944839B2

公开(公告)日：2024-04-02

申请号：US18309870

申请日：2023-05-01

Applicant: Emad Eskandar

Inventor： Emad N. Eskandar ,  James Joseph Cohen

IPC: A61N5/04 ,  A61B18/00 ,  A61B18/18 ,  A61B90/00 ,  A61N5/02 ,  H01S1/02 ,  H01S1/06

CPC classification number: A61N5/045 ,  A61B18/1815 ,  A61B90/36 ,  H01S1/02 ,  H01S1/06 ,  A61B2018/0016 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/1861 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N2005/027

Abstract: Low power MASER (Microwave Amplification by Stimulated Emission of Radiation) radiation is used to non-invasively record molecular activity in a biological object such as a brain. Low power MASER radiation is also used to neuromodulate molecular targets via Rabi coupling, resulting for example in conformational and function change in specific molecular targets such as ligand-gated ion channels, voltage-gated ion channels, G-proteins, or dopamine receptors. The method can be used to change the energy state of targeted molecules via energization or enervation, or to ablate targeted molecules.

公开(公告)号：US11872386B2

公开(公告)日：2024-01-16

申请号：US17148215

申请日：2021-01-13

Applicant: Emad Eskandar

Inventor： James Joseph Cohen ,  Emad N. Eskandar

IPC: H01S1/02 ,  A61N5/04 ,  A61B90/00 ,  A61B18/18 ,  H01S1/06 ,  A61B18/00 ,  A61N5/02

CPC classification number: A61N5/045 ,  A61B18/1815 ,  A61B90/36 ,  H01S1/02 ,  H01S1/06 ,  A61B2018/0016 ,  A61B2018/00446 ,  A61B2018/00577 ,  A61B2018/1861 ,  A61B2090/374 ,  A61B2090/3762 ,  A61N2005/027

Abstract: A MASER (Microwave Amplified Stimulated Emission of Radiation) emitter is fabricated of thin film components, including a thin film of nitrogen-implanted, epitaxial crystal diamond. The MASER elements can also include a controllable Q-switching layer and be arranged in a thin panel, phased array to generate a single beam of coherent, mode-locked, continuous wave MASER radiation.

公开(公告)号：US11641088B2

公开(公告)日：2023-05-02

申请号：US17148275

申请日：2021-01-13

Applicant: Emad Eskandar

Inventor： James Joseph Cohen ,  Emad N. Eskandar

IPC: H01S4/00 ,  H01S1/04 ,  H01S1/02 ,  H01S1/00 ,  A61B90/00 ,  A61B18/18 ,  A61N5/04 ,  H01S1/06 ,  A61B18/00 ,  A61N5/02

Abstract: A phased-array MASER detector for synthetic aperture interferometric three-dimensional imaging. The detector elements, for example 102-106 zero bias Schottky detector diodes with sufficient sensitivity to reliably detect various values of MASER radiation, are arranged in layers offset in three dimensions. The phased-array MASER detector is particularly useful for detecting characteristics in a biological object using low energy (2-10 Watts), coherent MASER radiation. MASER intensity data of an interferometric pattern is collected by the detector array, is deconvolved, and is used to generate three-dimensional energy activity maps for a given time slice or on a time-shifting basis.

公开(公告)号：US12172040B2

公开(公告)日：2024-12-24

申请号：US17475729

申请日：2021-09-15

Applicant: Emad Eskandar

Inventor： James Joseph Cohen ,  Emad Eskandar

IPC: A62B7/10 ,  A61L9/20 ,  A61L9/22 ,  A62B7/02 ,  A62B9/00 ,  A62B9/02 ,  A62B23/02 ,  G06T7/20

Abstract: A wearable respiratory isolation system is configured as an open collar to be worn loosely around the neck of the user, with an articulating arm positioning a mouthpiece in front of the mouth and nasal region of the user. The system provides filtered and sterilized air through a inhalation vent on the mouthpiece which creates a curtain of sterilized air in front of the users face, which protects the users face from air bourne pathogens provides sterile air for the user to inhale. Exhaled air is extracted through an exhalation vent on the mouthpiece, is decontaminated and exhausted to the rear of the user. A modified, background oriented Schlieren imaging technique is used to determine whether the user is inhaling or exhaling, and this information is used to control the flow of sterilized air and the capture of exhaled gases.