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公开(公告)号：US06192261B1
公开(公告)日：2001-02-20
申请号：US09072912
申请日：1998-05-04
申请人： Enrico Gratton , Sergio Fantini , Maria Angela Franceschini , William Mantulin , Beniamino Barbieri
发明人： Enrico Gratton , Sergio Fantini , Maria Angela Franceschini , William Mantulin , Beniamino Barbieri
IPC分类号： A61B500
CPC分类号： G01N21/314 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , A61B5/6824 , A61B2562/0233 , A61B2562/046 , G01N21/49
摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.
摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以不同于光调制频率的频率进行调制。 可以以作为上述两个频率之间的差的频率以不同的距离从每个光源获取数据。 根据来自各个光源的这些数据集，可以构建曲线，并且用于定量测定存在的某些材料的量的斜率，例如活体组织中的葡萄糖，氧合血红蛋白和脱氧血红蛋白。
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公开(公告)号：US5772587A
公开(公告)日：1998-06-30
申请号：US564439
申请日：1995-11-29
申请人： Enrico Gratton , Sergio Fantini , Maria Angela Franceschini , William Mantulin , Beniamino Barbieri
发明人： Enrico Gratton , Sergio Fantini , Maria Angela Franceschini , William Mantulin , Beniamino Barbieri
CPC分类号： G01N21/314 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , G01N21/49 , A61B2562/0233 , A61B2562/046 , A61B5/6824
摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.
摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以不同于光调制频率的频率进行调制。 可以以作为上述两个频率之间的差的频率以不同的距离从每个光源获取数据。 根据来自各个光源的这些数据集，可以构建曲线，并且用于定量测定存在的某些材料的量的斜率，例如活体组织中的葡萄糖，氧合血红蛋白和脱氧血红蛋白。
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公开(公告)号：US5497769A
公开(公告)日：1996-03-12
申请号：US168813
申请日：1993-12-16
申请人： Enrico Gratton , Sergio Fantini , Maria A. Franceschini , William Mantulin , Beniamino Barbieri
发明人： Enrico Gratton , Sergio Fantini , Maria A. Franceschini , William Mantulin , Beniamino Barbieri
CPC分类号： A61B5/14552 , A61B5/0059 , A61B5/14532 , A61B5/1455 , G01N21/314 , G01N21/49 , A61B2562/0233 , A61B2562/046
摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example oxyhemoglobin and deoxyhemoglobin in living tissue.
摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以不同于光调制频率的频率进行调制。 可以以作为上述两个频率之间的差的频率以不同的距离从每个光源获取数据。 根据来自每个单独光源的这些数据集，可以构建曲线，并且用于定量确定存在的某些材料的量的斜率，例如活体组织中的氧合血红蛋白和脱氧血红蛋白。
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4.发明授权Method for measuring absolute saturation of time-varying and other hemoglobin compartments 失效测量时变和其他血红蛋白隔室绝对饱和度的方法公开(公告)号：US06216021B1
公开(公告)日：2001-04-10
申请号：US09326779
申请日：1999-06-04
IPC分类号： A61B500
CPC分类号： A61B5/14551 , A61B5/14552 , A61B5/7257
摘要： The present invention involves a time-resolved measurement method for the real time, non-invasive, simultaneous measurement of time-varying and other hemoglobin compartment saturation. This capability achieves absolute pulse oximetry and oximetry for tissue, without calibration based on a population of healthy people. Calculations conducted by the invention use quantitative measurement of tissue absorption spectrum for tissue saturation, and an amplitude of absorption oscillations for the time-varying hemoglobin compartments at various wavelengths. The invention illuminates tissue and senses light at predetermined distances apart on the tissue to be measured. Intensity and phase data are acquired from source-detector pairs to calculate absolute tissue optical properties from time-resolved measurement data, namely, a reduced scattering coefficient and an absorption coefficient. To determine time-varying hemoglobin compartment saturation, an amplitude is quantitatively calculated of absorption oscillations correlating variations of an average intensity of the source and detector pair by using the time-resolved measurement data.
摘要翻译： 本发明涉及时间分辨测量方法，用于实时，非侵入性，同时测量时变和其他血红蛋白室饱和度。 该功能可实现组织的绝对脉搏血氧饱和度和血氧饱和度测量，无需基于健康人群进行校准。 本发明进行的计算使用组织饱和度组织吸收光谱的定量测量，以及不同波长下时变血红蛋白隔室的吸收振荡振幅。 本发明照亮组织并感测待测组织上预定距离的光。 从源 - 检测器对获取强度和相位数据，以从时间分辨测量数据计算绝对组织光学性质，即减小的散射系数和吸收系数。 为了确定时变血红蛋白室饱和度，通过使用时间分辨测量数据，定量计算与源和检测器对的平均强度的变化相关的吸收振荡的振幅。
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公开(公告)号：US06985763B2
公开(公告)日：2006-01-10
申请号：US10466447
申请日：2001-11-30
IPC分类号： A61B5/00
CPC分类号： A61B5/6828 , A61B5/02152 , A61B5/08 , A61B5/0816 , A61B5/14551 , A61B5/14552 , A61B5/7257 , G01N21/314
摘要： A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (2). A reduced scattering coefficient and an absorption coefficient are determined for the tissue, with the result that an effective path length can be determined (6). Data processing is performed to calculate amplitudes for the absorption oscillation data that are translated into oxygenated and deoxygenated hemoglobin concentrations for the venous compartment (8). A method of the invention does not required mechanical ventilation devices or venous perturbation. Additional method steps may entail verifying that the measured absorption oscillation data results from the venous compartment.
摘要翻译： 用于测量静脉血氧饱和度水平的方法具有以多个波长测量呼吸频率的光吸收振荡数据的步骤（2）。 确定组织的降低的散射系数和吸收系数，结果可以确定有效的路径长度（6）。 进行数据处理以计算被转化为静脉隔室（8）的氧化和脱氧血红蛋白浓度的吸收振荡数据的振幅。 本发明的方法不需要机械通气装置或静脉扰动。 额外的方法步骤可能需要验证测量的吸收振荡数据是从静脉室产生的。
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公开(公告)号：US5492118A
公开(公告)日：1996-02-20
申请号：US253935
申请日：1994-06-03
CPC分类号： G01N21/314 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/14552 , G01N21/49 , A61B2562/0233 , A61B2562/046 , A61B5/6824
摘要： The relative concentration of a material such as glucose in a turbid medium such as living tissue may determining the scattering coefficient of the light that has passed through the turbid medium; and comparing the scattering coefficient with a previous scattering coefficient determined with respect to the turbid medium.
摘要翻译： 诸如生物组织等混浊介质中的葡萄糖等物质的相对浓度可以确定通过混浊介质的光的散射系数; 并将散射系数与相对于混浊介质确定的先前散射系数进行比较。
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公开(公告)号：US07962187B2
公开(公告)日：2011-06-14
申请号：US10507336
申请日：2003-03-13
申请人： Sergio Fantini
发明人： Sergio Fantini
IPC分类号： A61B5/00
CPC分类号： A61B5/0091 , A61B5/4312
摘要： Systems and methods are disclosed for detecting at least one region of a sample having an absorption level different from a background level of absorption in the sample by obtaining thicknesses of the sample and intensities of light transmitted through the sample at a plurality of locations. The system includes glass plates (10) for compressing the tissue, distance sensors (20, 30), illuminations fibers (40) connected to a light source (70), and collection fibers (50) connected to spectrograph (110). Spatial second derivatives are calculated from products of the thicknesses of the sample and the intensities of the transmitted light for the locations. The data points are compared to detect the region of the sample having an absorption level different from the background level of absorption within the sample. The new systems and method can be used to optically image, detect, and characterize tissue, lesions, such as cancer.
摘要翻译： 公开了用于通过获得样品的厚度和在多个位置处透过样品的光的强度来检测具有与样品中的背景吸收水平不同的吸收水平的样品的至少一个区域的系统和方法。 该系统包括用于压缩组织的玻璃板（10），距离传感器（20,30），连接到光源（70）的照明光纤（40）和连接到光谱仪（110）的收集光纤（50）。 空间二阶导数由样本厚度和位置透射光强度的乘积计算。 比较数据点以检测具有与样品内的吸收背景水平不同的吸收水平的样品区域。 新的系统和方法可用于光学成像，检测和表征组织，病变如癌症。
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公开(公告)号：US20060106293A1
公开(公告)日：2006-05-18
申请号：US10507336
申请日：2003-03-13
申请人： Sergio Fantini
发明人： Sergio Fantini
CPC分类号： A61B5/0091 , A61B5/4312
摘要： Systems and methods are disclosed for detecting at least one region of a sample having an absorption level different from a background level of absorption in the sample by obtaining thicknesses of the sample and intensities of light transmitted through the sample at a plurality of locations. The system includes glass plates (10) for compressing the tissue, distance sensors (20, 30), illuminations fibers (40) connected to a light source (70), and collection fibers (50) connected to spectrograph (110). Spatial second derivatives are calculated from products of the thicknesses of the sample and the intensities of the transmitted light for the locations. The data points are compared to detect the region of the sample having an absorption level different from the background level of absorption within the sample. The new systems and method can be used to optically image, detect, and characterize tissue, lesions, such as cancer.
摘要翻译： 公开了用于通过获得样品的厚度和在多个位置处透过样品的光的强度来检测具有与样品中的背景吸收水平不同的吸收水平的样品的至少一个区域的系统和方法。 该系统包括用于压缩组织的玻璃板（10），距离传感器（20,30），连接到光源（70）的照明光纤（40）和连接到光谱仪（110）的收集光纤（50）。 空间二阶导数由样本厚度和位置透射光强度的乘积计算。 比较数据点以检测具有与样品内的吸收背景水平不同的吸收水平的样品区域。 新的系统和方法可用于光学成像，检测和表征组织，病变如癌症。
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公开(公告)号：US20090062685A1
公开(公告)日：2009-03-05
申请号：US12293146
申请日：2007-03-16
申请人： Peter R. Bergethon , Sergio Fantini
发明人： Peter R. Bergethon , Sergio Fantini
CPC分类号： A61B5/04001 , A61B5/0059 , A61B5/05 , A61B5/4029 , A61B5/4041 , A61N1/36014 , G01N21/359
摘要： Near-infrared spectroscopy (NIRS) is employed to examine the neuronal activity and vascular response of a peripheral nerve for research or clinical purposes. An embodiment for implementing this approach has: a nerve stimulator; a tissue spectrometer; a stimulation probe adapted to apply a stimulation from the nerve stimulator to a peripheral nerve; at least one illumination optical fiber, where each illumination optical fiber is adapted to transmit a near-infrared source light to the peripheral nerve after the stimulation is applied; and a detection optical fiber adapted to collect and deliver to the tissue spectrometer a returning light from the peripheral nerve after each source light is transmitted to the peripheral nerve. The returning light has a returning intensity, and the tissue spectrometer can determine the returning intensity to provide readings of optical diffuse reflectance of the peripheral nerve after the stimulation is applied.
摘要翻译： 近红外光谱（NIRS）用于检查外周神经的神经元活动和血管反应，用于研究或临床目的。 实施这种方法的一个实施例有：神经刺激器; 组织光谱仪; 刺激探针适于将刺激从神经刺激器施加到周围神经; 至少一个照明光纤，其中每个照明光纤适于在施加刺激之后将近红外光源发射到周围神经; 以及检测光纤，其适于在每个源光被透射到周围神经之后，收集并传送到组织光谱仪来自周围神经的返回光。 返回光具有返回强度，并且组织光谱仪可以确定返回强度，以在施加刺激之后提供周围神经的光学漫反射率的读数。
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