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公开(公告)号:US07919617B2
公开(公告)日:2011-04-05
申请号:US12637712
申请日:2009-12-14
申请人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号: C07D265/30 , A61K31/5377
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地,本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号:US07897599B2
公开(公告)日:2011-03-01
申请号:US12637714
申请日:2009-12-14
申请人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号: A61K31/535 , C07D265/30
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
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公开(公告)号:US07749999B2
公开(公告)日:2010-07-06
申请号:US10939324
申请日:2004-09-10
申请人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang , Jeffrey Kahl , Christopher Larson
发明人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang , Jeffrey Kahl , Christopher Larson
IPC分类号: A61K31/535 , C07D265/30
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地,本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号:US20100273797A1
公开(公告)日:2010-10-28
申请号:US12829701
申请日:2010-07-02
申请人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号: A61K31/5377 , A61K31/5375 , A61K31/437 , A61P9/00 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/06 , A61P25/00 , A61P25/28 , A61P3/04 , A61P17/00
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.
摘要翻译: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地,本发明的化合物可用作抗炎剂。 还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。
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公开(公告)号:US20100093735A1
公开(公告)日:2010-04-15
申请号:US12637714
申请日:2009-12-14
申请人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号: A61K31/535 , C07D295/155
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
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公开(公告)号:US20100093734A1
公开(公告)日:2010-04-15
申请号:US12637712
申请日:2009-12-14
申请人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人: Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号: A61K31/5375 , C07D295/14
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地,本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号:US20050107399A1
公开(公告)日:2005-05-19
申请号:US10939324
申请日:2004-09-10
申请人: Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人: Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号: A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC分类号: A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要: The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译: 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地,本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号:US09008884B2
公开(公告)日:2015-04-14
申请号:US13327035
申请日:2011-12-15
CPC分类号: B65G1/0492 , G05D1/0272 , G05D2201/0216
摘要: A storage and retrieval system including a storage structure having storage shelves, each storage shelf having slats for supporting stored items where the slats are spaced apart from each other by a predetermined distance, an autonomous transport vehicle including at least one sensor configured to sense each of the slats and output a signal indicating when a slat is sensed, and a controller for verifying a location of the autonomous transport vehicle within the storage structure based on at least the output signal.
摘要翻译: 一种存储和检索系统,包括具有存储架的存储结构,每个存储架具有用于支撑所述板条彼此间隔开预定距离的存储物品的板条;自动运输车辆,包括至少一个传感器, 板条并输出指示何时感测到板条的信号,以及用于至少基于输出信号来验证存储结构内的自主运输车辆的位置的控制器。
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公开(公告)号:US20120195720A1
公开(公告)日:2012-08-02
申请号:US13326674
申请日:2011-12-15
申请人: Robert Sullivan , John Lert
发明人: Robert Sullivan , John Lert
IPC分类号: B65G1/06
摘要: A storage and retrieval system is provided and includes a transfer deck having a longitudinal axis, a first storage section and a second storage section. The first storage section and second storage section are located on opposite sides of the transfer deck and are substantially symmetrically opposed to one another about the longitudinal axis, where each of the first and second storage sections includes storage aisles that are in communication with the transfer deck.
摘要翻译: 提供存储和取回系统,并且包括具有纵向轴线的转移甲板,第一存储部分和第二存储部分。 第一存储部分和第二存储部分位于转移甲板的相对侧上并且围绕纵向轴线彼此基本上对称地相对,其中第一和第二存储部分中的每一个包括与转移甲板连通的存储通道 。
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公开(公告)号:US20100316470A1
公开(公告)日:2010-12-16
申请号:US12757337
申请日:2010-04-09
申请人: John Lert , Stephen Toebes , Robert Sullivan , Foster D. Hinshaw , Nathan Ulrich , Eric Peters
发明人: John Lert , Stephen Toebes , Robert Sullivan , Foster D. Hinshaw , Nathan Ulrich , Eric Peters
CPC分类号: B65G1/0492 , B65G1/045 , B65G1/065 , B65G1/10 , B65G1/127 , B65G1/137 , B65G1/1371 , B65G1/1373 , B65G1/1378 , B65G47/57 , Y10S901/01
摘要: A warehouse storage and retrieval system including an array of multilevel storage racks having at least one transfer deck, picking isles and storage areas disposed along picking isles, the storage areas being configured to hold differing loads, and a controller including a management module configured to variably size the storage areas of the array of multilevel storage rack modules and assign each of the variably sized storage areas to a corresponding one of the differing loads, wherein the storage and retrieval system is arranged to transport the differing loads for placement in the variably sized storage areas assigned by the controller.
摘要翻译: 一种仓库存储和检索系统,包括具有至少一个转移甲板,拾取岛和沿着采摘岛布置的存储区域的多层存储架的阵列,所述存储区域被配置为保持不同的负载,以及控制器,包括管理模块,其可配置为可变地 对多级存储机架模块阵列的存储区域进行大小,并将每个可变大小的存储区域分配给不同负载中的相应的一个,其中存储和检索系统被布置成传送不同的负载以放置在可变大小的存储器 控制器分配的区域。
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