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公开(公告)号：US20100093735A1
公开(公告)日：2010-04-15
申请号：US12637714
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号： A61K31/535 , C07D295/155
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
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公开(公告)号：US20100093734A1
公开(公告)日：2010-04-15
申请号：US12637712
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G.J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5375 , C07D295/14
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号：US07919617B2
公开(公告)日：2011-04-05
申请号：US12637712
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号： C07D265/30 , A61K31/5377
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号：US07897599B2
公开(公告)日：2011-03-01
申请号：US12637714
申请日：2009-12-14
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang
IPC分类号： A61K31/535 , C07D265/30
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
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公开(公告)号：US07749999B2
公开(公告)日：2010-07-06
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang , Jeffrey Kahl , Christopher Larson
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhinjun Wang , Jeffrey Kahl , Christopher Larson
IPC分类号： A61K31/535 , C07D265/30
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号：US20100273797A1
公开(公告)日：2010-10-28
申请号：US12829701
申请日：2010-07-02
申请人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Conde Ceide , Russell Dahl , Nancy G. J. Delaet , Justin Ernst , Antonio Garrido Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/5377 , A61K31/5375 , A61K31/437 , A61P9/00 , A61P19/02 , A61P1/00 , A61P29/00 , A61P37/06 , A61P25/00 , A61P25/28 , A61P3/04 , A61P17/00
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions medicated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了用于制备这些药剂的方法及其在预防或治疗由诸如关节炎的细胞因子药物治疗的病症中的用途。
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公开(公告)号：US20050107399A1
公开(公告)日：2005-05-19
申请号：US10939324
申请日：2004-09-10
申请人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
发明人： Erik Boman , Susana Ceide , Russell Dahl , Nancy Delaet , Justin Ernst , Antonio Montalban , Jeffrey Kahl , Christopher Larson , Stephen Miller , Hiroshi Nakanishi , Edward Roberts , Eddine Saiah , Robert Sullivan , Zhijun Wang
IPC分类号： A61K31/416 , A61K31/4965 , C07D20060101 , C07D403/12
CPC分类号： A61K31/416 , C07D207/40 , C07D231/12 , C07D231/40 , C07D239/47 , C07D249/12 , C07D253/075 , C07D295/088 , C07D403/12 , C07D471/04 , C07D487/04 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines such as arthritis.
摘要翻译： 本发明提供可用作细胞因子抑制剂的低分子量化合物及其组合物。 特别地，本发明的化合物可用作抗炎剂。 还提供了制备这些试剂的方法及其在预防或治疗由细胞因子如关节炎介导的病症中的用途。
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公开(公告)号：US20050215563A1
公开(公告)日：2005-09-29
申请号：US11043697
申请日：2005-01-25
申请人： Andrew Hamilton , Justin Ernst , Brendan Orner
发明人： Andrew Hamilton , Justin Ernst , Brendan Orner
IPC分类号： A61P25/28 , A61P31/12 , C07C57/38 , C07C59/68 , C07C69/712 , C07C69/736 , C07D213/79 , C07D213/81 , C07D241/04 , C07D295/02 , C07D295/033 , C07D295/185 , A61K31/496 , A61K31/497 , C07D43/14
CPC分类号： C07D213/79 , C07C57/38 , C07C59/68 , C07C69/712 , C07C69/736 , C07D213/81 , C07D241/04 , C07D295/033 , C07D295/185
摘要： The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.
摘要翻译： 本发明涉及蛋白质组学的化合物和药物组合物以及抑制α-螺旋蛋白与另一种蛋白质或结合位点相互作用的方法。 用于治疗通过α螺旋蛋白及其结合位点之间的相互作用调节的疾病或病症的方法是本发明的其它方面。
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公开(公告)号：US07312246B2
公开(公告)日：2007-12-25
申请号：US11043697
申请日：2005-01-25
申请人： Andrew D. Hamilton , Justin Ernst , Brendan Orner
发明人： Andrew D. Hamilton , Justin Ernst , Brendan Orner
IPC分类号： A01N37/10
CPC分类号： C07D213/79 , C07C57/38 , C07C59/68 , C07C69/712 , C07C69/736 , C07D213/81 , C07D241/04 , C07D295/033 , C07D295/185
摘要： The present invention relates to compounds and pharmaceutical compositions which are proteonaimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention. In particular, the invention relates to treatment of viral infections using terphenyl derivatives.
摘要翻译： 本发明涉及具有蛋白质含义的化合物和药物组合物以及抑制α-螺旋蛋白与另一种蛋白质或结合位点相互作用的方法。 用于治疗通过α螺旋蛋白及其结合位点之间的相互作用调节的疾病或病症的方法是本发明的其它方面。 特别地，本发明涉及使用三联苯衍生物治疗病毒感染。
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公开(公告)号：US06858600B2
公开(公告)日：2005-02-22
申请号：US10142126
申请日：2002-05-08
IPC分类号： A61P25/28 , A61P31/12 , C07C57/38 , C07C59/68 , C07C69/712 , C07C69/736 , C07D213/79 , C07D213/81 , C07D241/04 , C07D295/02 , C07D295/033 , C07D295/185 , A61K31/33 , C07D241/00 , C07D295/00 , A61K312/495
CPC分类号： C07D213/79 , C07C57/38 , C07C59/68 , C07C69/712 , C07C69/736 , C07D213/81 , C07D241/04 , C07D295/033 , C07D295/185
摘要： The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention.
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