Isomerisation process
    1.
    发明授权
    Isomerisation process 失效
    异构化过程

    公开(公告)号:US5334744A

    公开(公告)日:1994-08-02

    申请号:US995861

    申请日:1992-12-23

    CPC classification number: C07C255/38

    Abstract: A process for obtaining an isomer of a compound of general formulaR--CH(CN)--R' (I)wherein each of R and R' may be any organic radical linked directly or through a heteroatom to the carbon atom bearing the cyano group provided that at least one of R and R' comprises at least one resolved chiral center which is stable under the conditions of the process, or a racemic modification comprising the isomer and its enantiomer, which comprises the step of treating the epimer of the isomer, or the racemate comprising the epimer and the enantiomer of the epimer, in solution in a polar organic solvent, or in slurry in a polar organic liquid diluent in which the epimer or the racemate is partially soluble, with a source of cyanide ions, in the absence of a base, the isomer, or the racemic modification comprising the isomer and its enantiomer, being less soluble in the solvent or diluent than the epimer of the isomer, or the racemate comprising the epimer of the isomer and the enantiomer of the epimer, respectively.

    Abstract translation: 获得通式为R-CH(CN)-R'(I)的化合物的异构体的方法,其中R和R'各自可以是直接或通过杂原子与带有氰基的碳原子连接的任何有机基团 条件是R和R'中的至少一个包含至少一个在该方法的条件下是稳定的拆分的手性中心,或包含异构体及其对映异构体的外消旋体,其包括处理异构体的差向异构体的步骤, 或包含差向异构体和差向异构体的对映异构体的外消旋物,在极性有机溶剂中的溶液中,或在极性有机液体稀释剂中的浆液中,其中差向异构体或外消旋体部分可溶于氰化物离子源 不含碱基,异构体或包含异构体及其对映异构体的外消旋体,比异构体的差向异构体更难溶于溶剂或稀释剂,或包含异构体的差向异构体和epim对映异构体的外消旋体 呃。

    Chiral compounds
    5.
    发明授权
    Chiral compounds 失效
    手性化合物

    公开(公告)号:US4343935A

    公开(公告)日:1982-08-10

    申请号:US166837

    申请日:1980-07-08

    CPC classification number: C07D213/53 C07H15/12

    Abstract: Chiral Schiff bases, and transition metal complexes thereof, of formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same ordifferent, are hydrogen, alkyl, aralkyl, aryl, alkaryl, a substituent containing a hetero atom, or two of R.sup.1, R.sup.2 and R.sup.3 together with the pyridine ring from fused system, R.sup.4 and R.sup.5 which may be the same or different, are hydrogen, lower alkyl, or, where n is 1, may with the pyridine ring to which CR.sup.4 R.sup.5 is attached form a fused system, R.sup.6 is hydrogen, alkyl, aralkyl, aryl or alkaryl, n is 0, 1 or 2 and J and K, which may be the same or different, are groups of the formulae: ##STR2## in which C* is an asymmetric carbon atom, and R.sup.7 and R.sup.8, which may be the same or different, are alkyl, aralkyl, aryl or alkaryl, or ##STR3## in which at least the ring carbon atom to which the iminyl nitrogen atom is attached is asymmetric, at least one of the carbon atoms adjacent the said ring carbon atom bears a hydroxyl group, R.sup.9 and R.sup.14, which may be the same or different, are hydrogen or lower alkyl, R.sup.10 is hydrogen, or lower alkyl, or together with R.sup.15 forms a divalent hydrocarbyl group, R.sup.11 is hydrogen, a sugar residue, or --CH.sub.2 OR.sup.15 in which R.sup.15 is hydrogen, lower alkyl or together with R.sup.10 forms a divalent hydrocarbon group, R.sup.12 is hydrogen or --CH.sub.2 OR.sup.15 in which R.sup.15 is hydrogen, or a lower alkyl, R.sup.13 is hydrogen, OR.sup.1, or a sugar residue, provided that both R.sup.12 and R.sup.13 are not hydrogen, m is 0, 1 or 2, p is 0 or 1 provided that m plus p is 0, 1, 2 or 3. The transition metal is for example copper (II), chromium (II), manganese (II), iron (II), cobalt (II), nickel (II) or palladium (II). The aforesaid complexes may be used as catalysts in the cyclopropanation of olefins by diazoacetates to form insecticide or insecticide precursors.

    Abstract translation: 手性席夫碱及其过渡金属配合物,其分子式为:其中R 1,R 2和R 3可以相同,可以是氢,烷基,芳烷基,芳基,烷芳基,含有杂原子的取代基,或两个 的R 1,R 2和R 3与来自稠合体系的吡啶环一起可以相同或不同的R 4和R 5是氢,低级烷基,或者其中n是1,可以与CR 4 R 5连接的吡啶环形成 稠合体系,R6是氢,烷基,芳烷基,芳基或烷芳基,n是0,1或2,并且可以相同或不同的J和K是下式的基团:其中C *是 不对称碳原子和可以相同或不同的R 7和R 8是烷基,芳烷基,芳基或烷芳基或其中至少与亚氨基氮原子连接的环碳原子不对称的“ 与所述环碳原子相邻的碳原子中的至少一个具有羟基,可以相同或不同的R 9和R 14为h 低级烷基或低级烷基,R 10为氢或低级烷基,或与R 15一起形成二价烃基,R 11为氢,糖残基或-CH 2 OR 15,其中R 15为氢,低级烷基或与R 10一起形成二价烃 基团,R 12是氢或-CH 2 OR 15,其中R 15是氢,或低级烷基,R 13是氢,OR 1或糖残基,条件是R 12和R 13都不是氢,m是0,1或2,p是 0或1,条件是m + p为0,1,2或3.过渡金属为例如铜(II),铬(II),锰(II),铁(II),钴(II) II)或钯(II)。 上述络合物可以用作催化剂,通过重氮乙酸酯将烯烃环丙烷化形成杀虫剂或杀虫剂前体。

    Process for the preparation of alkyl furans
    6.
    发明授权
    Process for the preparation of alkyl furans 失效
    制备烷基呋喃的方法

    公开(公告)号:US4323509A

    公开(公告)日:1982-04-06

    申请号:US262775

    申请日:1981-05-11

    Inventor: David J. Milner

    CPC classification number: C07D307/36 B01J27/10

    Abstract: A process for the preparation of alkyl furans which comprises reacting furan with an alkyl halide in the presence of iron (III) oxide and an iron (II) halide or iron (III) halide as catalyst.

    Abstract translation: 一种制备烷基呋喃的方法,其包括在氧化铁(III)和卤化铁(II)或卤化铁(III)作为催化剂的情况下使呋喃与烷基卤化物反应。

    Process for the preparation of cyanotetrachlorobenzenes
    7.
    发明授权
    Process for the preparation of cyanotetrachlorobenzenes 失效
    氰基四氯苯的制备方法

    公开(公告)号:US4517129A

    公开(公告)日:1985-05-14

    申请号:US575997

    申请日:1984-02-01

    Inventor: David J. Milner

    CPC classification number: C07C255/00

    Abstract: Cyanotetrachlorobenzenes, especially ortho- and para- dicyanotetrachlorobenzenes, are prepared by reacting in a liquid medium at 20.degree.-100.degree. C. a corresponding nitrotetrachlorobenzene with, in solution, an inorganic cyanide. Preferably the liquid medium is a two-phase water/water-immiscible organic solvent system, e.g. water/chloroform, a phase transfer catalyst is present and the inorganic cyanide is an alkali metal or alkaline earth metal cyanide.The compounds are useful chemical intermediates in the synthesis of, for instance, pesticidal compounds.

    Abstract translation: 氰基四氯苯,特别是邻二氯和对二氰基四氯苯,通过在20°-100℃的液体介质中与相应的硝基四氯苯与溶液中的无机氰化物反应来制备。 优选地,液体介质是两相水/水不混溶的有机溶剂系统,例如。 水/氯仿,存在相转移催化剂,无机氰化物是碱金属或碱土金属氰化物。 这些化合物在合成例如杀虫化合物中是有用的化学中间体。

    Preparation of polycyclic dyes
    10.
    发明授权
    Preparation of polycyclic dyes 失效
    多环染料的制备

    公开(公告)号:US5304659A

    公开(公告)日:1994-04-19

    申请号:US57806

    申请日:1993-05-07

    Inventor: David J. Milner

    CPC classification number: C07D493/04 C07C239/20 C09B57/00

    Abstract: A process for the preparation of a polycyclic dye of Formula (1): ##STR1## by reacting a compound of Formula (2): ##STR2## with a benzofuranone of the Formula (3): ##STR3## wherein: Ring A is unsubstituted or is substituted by from one to three groups;Ring B is unsubstituted, apart from the nitro group, or is substituted by one or two further groups;R is H, optionally substituted alkyl or optionally substituted aryl; andZ is an oxyammonium group, and certain novel compounds of Formula (2) are disclosed.The process provides a convenient route to polycyclic dyes which are useful for the coloration of synthetic textile materials particularly polyesters.

    Abstract translation: 制备式(1)的多环染料的方法:(*化学结构*)式1通过使式(2)的化合物:(*化学结构*)式(2)与式(2)的苯并呋喃酮反应, 3):(*化学结构*)式3其中:环A是未取代的或被一至三个基团取代; 环B除了硝基以外是未取代的,或被一个或两个另外的基团取代; R为H,任选取代的烷基或任选取代的芳基; Z是氧基铵基,并且公开了某些新的式(2)化合物。 该方法提供了多环染料的方便途径,其可用于合成纺织品特别是聚酯的着色。

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