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1.发明授权Substituted phenylcyclohexane carboxylic acid amides and their use as adenosine uptake inhibitors 失效取代的苯基环己烷羧酸酰胺及其作为腺苷摄取抑制剂的用途公开(公告)号：US06984642B1
公开(公告)日：2006-01-10
申请号：US09980242
申请日：2000-05-16
申请人： Erwin Bischoff , Stephan Lensky , Stephan-Nicholas Müller , Holger Paulsen , Jörg Keldenich , Thomas Krahn , Joachim Schuhmacher , Jan Jänichen , Wolfgang Thielemann , Henning Steinhagen
发明人： Erwin Bischoff , Stephan Lensky , Stephan-Nicholas Müller , Holger Paulsen , Jörg Keldenich , Thomas Krahn , Joachim Schuhmacher , Jan Jänichen , Wolfgang Thielemann , Henning Steinhagen
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D235/24 , A61K31/4184 , A61K31/437 , C07D235/12 , C07D235/14 , C07D235/30 , C07D471/04
摘要： The present invention relates to substituted phenylcyclohexanecaboxamides of the formula (I), to processes for their preparation and to their use in medicaments, in particular for treating cardiovascular disorders.
摘要翻译： 本发明涉及式（I）的取代的苯基环己烷甲酰胺，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病。
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公开(公告)号：US07074780B2
公开(公告)日：2006-07-11
申请号：US10715283
申请日：2003-11-17
申请人： Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
发明人： Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
IPC分类号： A61K31/33 , A61K31/38 , A61K31/16 , C07D331/02 , C07D333/02
CPC分类号： C07D213/40 , C07C233/63 , C07C235/12 , C07C235/40 , C07C237/24 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/24 , C07C275/26 , C07C275/42 , C07C317/50 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/56 , C07D213/75 , C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/205 , C07D295/215
摘要： The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.
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公开(公告)号：US06649616B2
公开(公告)日：2003-11-18
申请号：US09943325
申请日：2001-08-30
申请人： Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
发明人： Erwin Bischoff , Thomas Krahn , Stephan-Nicholas Müller , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
IPC分类号： A61K3133
CPC分类号： C07D213/40 , C07C233/63 , C07C235/12 , C07C235/40 , C07C237/24 , C07C271/16 , C07C271/20 , C07C271/22 , C07C271/24 , C07C275/26 , C07C275/42 , C07C317/50 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D213/56 , C07D213/75 , C07D213/81 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/205 , C07D295/215
摘要： The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.
摘要翻译： 本发明涉及式（I）的取代的苯基环己烷甲酰胺，用于其制备方法及其在药物中的用途，特别是用于预防和/或治疗心血管疾病。
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4.发明申请Substituted piperazine cyclohexane carboxilic acid amides and the use thereof 审中-公开取代的哌嗪环己烷羧酸酰胺及其用途公开(公告)号：US20050054637A1
公开(公告)日：2005-03-10
申请号：US10492337
申请日：2002-10-01
申请人： Erwin Bischoff , Thomas Krahn , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
发明人： Erwin Bischoff , Thomas Krahn , Holger Paulsen , Joachim Schuhmacher , Henning Steinhagen , Wolfgang Thielemann
IPC分类号： C07D295/14 , A61K31/495 , A61K31/496 , A61K31/501 , A61P7/02 , A61P7/10 , A61P9/08 , A61P9/10 , A61P19/08 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P35/00 , A61P43/00 , C07D207/34 , C07D207/40 , C07D207/416 , C07D209/08 , C07D209/42 , C07D213/38 , C07D213/71 , C07D213/81 , C07D213/82 , C07D215/12 , C07D215/50 , C07D215/54 , C07D217/26 , C07D231/12 , C07D231/14 , C07D231/56 , C07D233/84 , C07D233/90 , C07D235/04 , C07D237/24 , C07D261/14 , C07D275/04 , C07D295/155 , C07D295/18 , C07D295/192 , C07D295/20 , C07D295/215 , C07D295/22 , C07D295/26 , C07D307/68 , C07D317/58 , C07D317/68 , C07D333/34 , C07D333/38 , C07D417/02 , C07D413/02 , C07D43/02
CPC分类号： C07D207/416 , C07D213/71 , C07D231/56 , C07D295/155 , C07D295/192 , C07D295/215 , C07D295/26 , C07D333/38
摘要： The present invention relates to substituted piperazinecyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in pharmaceuticals, in particular for the prophylaxis and/or treatment of cardiovascular disorders.
摘要翻译： 本发明涉及式（I）的取代的哌嗪环己烷甲酰胺，其制备方法及其在药物中的用途，特别是用于预防和/或治疗心血管疾病。
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公开(公告)号：US06649618B2
公开(公告)日：2003-11-18
申请号：US09906296
申请日：2001-07-16
申请人： Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Michael Härter , Barbara Albrecht , Michael Gerisch , Gabriele Handke , Joachim Hütter , Axel Jensen , Thomas Krahn , Joachim Mittendorf , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： C07D491048
CPC分类号： C07D401/06 , C07D239/96 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Novel amidoalkyl-uracil derivatives of the formula (I) in which A represents 1-3 ring atoms and X represents optionally substituted (C2-C10)alkylene or (C3-C8)cycloalkylene as defined in claim 1, a process for their preparation, and their use as medicaments for the prophylaxis and/or treatment of disorders are described.
摘要翻译： 式（I）的新型酰氨基烷基 - 尿嘧啶衍生物，其中A表示1-3个环原子，X表示如权利要求1所定义的任选取代的（C 2 -C 10）亚烷基或（C 3 -C 8）亚环烷基，其制备方法， 并描述其用作预防和/或治疗病症的药物。
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6.发明申请Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (pars) 失效取代的酰氨基烷基尿嘧啶及其作为聚（adp-核糖）合成酶（pars）抑制剂的用途公开(公告)号：US20050075347A1
公开(公告)日：2005-04-07
申请号：US10416622
申请日：2001-11-02
申请人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Erguden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Erguden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： C07D239/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04 , C07D519/00 , C07D521/00 , A61K31/519
CPC分类号： C07D231/12 , C07D233/56 , C07D239/96 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The invention relates to novel amidoalkyl uracil derivatives of formula (I), to a method for the production thereof, and to their use as medicament active substances for the prophylaxis and/or treatment of medical disorders.
摘要翻译： 本发明涉及式（I）的新型酰氨基烷基尿嘧啶衍生物，其制备方法及其作为用于预防和/或治疗医学病症的药物活性物质的用途。
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7.发明授权Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (PARS) 失效取代的酰氨基烷基尿嘧啶及其作为聚（adp-核糖）合成酶（PARS）的抑制剂的用途公开(公告)号：US07125995B2
公开(公告)日：2006-10-24
申请号：US10416622
申请日：2001-11-02
申请人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Ergüden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Barbara Albrecht , Michael Gerisch , Gabriele Handke-Ergüden , Axel Jensen , Thomas Krahn , Werner Nickl , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： C07D239/70 , C07D493/04 , C07D495/04 , A61K31/517 , A61P9/10
CPC分类号： C07D231/12 , C07D233/56 , C07D239/96 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D491/04 , C07D495/04
摘要： This application relates to compounds of formula (I) below in which the several variable groups are as defined in the specification and claims, to methods of preparing these materials, to pharmaceutical compositions containing these materials, and to methods of using these materials to treat ischaemia or reperfusion damage.
摘要翻译： 本申请涉及以下式（I）的化合物，其中几个可变基团如说明书和权利要求中所定义，制备这些材料的方法，含有这些材料的药物组合物以及使用这些材料来治疗局部缺血的方法 或再灌注损伤。
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公开(公告)号：US20050159431A1
公开(公告)日：2005-07-21
申请号：US10501033
申请日：2003-01-03
申请人： Barbara Albrecht , Michael Gerisch , Michael Harter , Thomas Krahn , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
发明人： Barbara Albrecht , Michael Gerisch , Michael Harter , Thomas Krahn , Felix Oehme , Karl-Heinz Schlemmer , Henning Steinhagen
IPC分类号： A61P9/10 , C07D239/96 , C07D401/06 , C07D403/06 , C07D409/12 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/519 , A61K31/517 , C07D491/02 , C07D498/02
CPC分类号： C07D401/06 , C07D239/96 , C07D403/06 , C07D409/12 , C07D491/04 , C07D495/04
摘要： The invention relates to novel compounds of formula (I), to a method for the production thereof, and to their use as medicament active ingredients for the prophylaxis and/or treatment of diseases.
摘要翻译： 本发明涉及式（I）的新型化合物，其制备方法及其作为预防和/或治疗疾病的药物活性成分的用途。
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9.发明授权Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶在治疗恶心和呕吐中的用途公开(公告)号：US07709504B2
公开(公告)日：2010-05-04
申请号：US11631755
申请日：2005-06-23
IPC分类号： A61K31/4418 , A61K31/4436 , A61K31/444
CPC分类号： A61K31/4427
摘要： The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) wherein the terms A and R2 are herein defined, for treatment of nausea and vomiting.
摘要翻译： 本发明涉及式（I）的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基 - 吡啶的用途，其中术语A和R2在本文中定义，用于治疗恶心和呕吐 。
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10.发明申请Use of Activators of Soluble Guanylate Cyclase for Promoting Wound Healing 审中-公开使用可溶性鸟苷酸环化酶的活化剂促进伤口愈合公开(公告)号：US20090221573A1
公开(公告)日：2009-09-03
申请号：US11988351
申请日：2006-07-06
申请人： Thomas Krahn , Johannes-Peter Stasch , Gerrit Weimann , Wolfgang Thielemann , Beatrix Stelte-Ludwig
发明人： Thomas Krahn , Johannes-Peter Stasch , Gerrit Weimann , Wolfgang Thielemann , Beatrix Stelte-Ludwig
IPC分类号： C07D413/12 , C07D471/04 , A61K31/5377 , C07D401/14 , A61K31/195 , C07D413/14 , A61K31/495 , A61K31/44 , C07C229/34
CPC分类号： A61K31/506
摘要： The present invention relates to a method for promoting wound healing by administering one or more compounds identified in the claims, and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及一种通过施用权利要求中鉴定的一种或多种化合物和包含这些化合物的药物组合物来促进伤口愈合的方法。
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