-
公开(公告)号：US09580708B2
公开(公告)日：2017-02-28
申请号：US14344523
申请日：2012-09-14
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2310/51 , C12N2310/52
摘要： The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
摘要翻译： 本公开提供了包含两个或多个靶特异性寡核苷酸（例如反义寡核苷酸（ASO））的多聚寡核苷酸化合物，其各自对切割具有抗性，并通过可切割连接子连接在一起。 特别地，两种或更多种连接的靶特异性寡核苷酸，各自到不同的靶标，允许同时抑制多种基因的表达水平，同时显示出有利的药代动力学和药效学性质。 还提供了制备和使用所述化合物的方法。
-
公开(公告)号：US20150299695A1
公开(公告)日：2015-10-22
申请号：US14344523
申请日：2012-09-14
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2310/51 , C12N2310/52
摘要： The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
摘要翻译： 本公开提供了包含两个或多个靶特异性寡核苷酸（例如反义寡核苷酸（ASO））的多聚寡核苷酸化合物，其各自对切割具有抗性，并通过可切割连接子连接在一起。 特别地，两种或更多种连接的靶特异性寡核苷酸，各自到不同的靶标，允许同时抑制多种基因的表达水平，同时显示出有利的药代动力学和药效学性质。 还提供了制备和使用所述化合物的方法。
-
公开(公告)号：US20130231294A1
公开(公告)日：2013-09-05
申请号：US13623822
申请日：2012-09-20
申请人： William D Carlson , Peter C. Keck , Michael Sworin , Dattatreyamurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
发明人： William D Carlson , Peter C. Keck , Michael Sworin , Dattatreyamurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
IPC分类号： C07K7/08
CPC分类号： A61K38/10 , A61K9/0019 , A61K9/5021 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K38/00 , A61K38/12 , C07K7/08 , C07K14/495 , G01N33/6872 , G01N2333/495
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
-
4.发明申请TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS 有权TDF相关化合物及其类似物，模拟物和生物活性片段公开(公告)号：US20100209467A1
公开(公告)日：2010-08-19
申请号：US11992161
申请日：2006-09-20
申请人： William D. Carlson , Peter C. Keck , Michael Sworin , Dattatreymurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
发明人： William D. Carlson , Peter C. Keck , Michael Sworin , Dattatreymurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
IPC分类号： A61K9/00 , C07K16/00 , A61K39/395 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K7/64 , A61K38/12 , A61P1/16 , A61P35/00 , A61P29/00 , A61P25/00 , A61P19/10 , A61P19/02 , A61P9/00 , A61K39/00 , G01N33/53 , G06G7/48 , A01K67/027 , C12N5/10 , B05D1/00
CPC分类号： A61K38/10 , A61K9/0019 , A61K9/5021 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K38/00 , A61K38/12 , C07K7/08 , C07K14/495 , G01N33/6872 , G01N2333/495
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
摘要翻译： 本发明一般涉及组织分化因子（TDF）类似物。 更具体地，本发明涉及用作设计，鉴定和产生作为TDF样受体的功能调节剂的分子的基于结构的方法和组合物。 本发明还涉及检测，预防和治疗TDF相关疾病的方法。
-
-
-
搜索结果
4 条记录 (耗时 0.072 秒)
