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公开(公告)号：US20130231294A1
公开(公告)日：2013-09-05
申请号：US13623822
申请日：2012-09-20
申请人： William D Carlson , Peter C. Keck , Michael Sworin , Dattatreyamurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
发明人： William D Carlson , Peter C. Keck , Michael Sworin , Dattatreyamurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
IPC分类号： C07K7/08
CPC分类号： A61K38/10 , A61K9/0019 , A61K9/5021 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K38/00 , A61K38/12 , C07K7/08 , C07K14/495 , G01N33/6872 , G01N2333/495
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
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2.发明申请TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS 有权TDF相关化合物及其类似物，模拟物和生物活性片段公开(公告)号：US20100209467A1
公开(公告)日：2010-08-19
申请号：US11992161
申请日：2006-09-20
申请人： William D. Carlson , Peter C. Keck , Michael Sworin , Dattatreymurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
发明人： William D. Carlson , Peter C. Keck , Michael Sworin , Dattatreymurty Bosukonda , Kellie Watson , Philippe Bey , Romesh Subramanian
IPC分类号： A61K9/00 , C07K16/00 , A61K39/395 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/07 , A61K38/08 , A61K38/10 , A61K38/16 , C07K7/64 , A61K38/12 , A61P1/16 , A61P35/00 , A61P29/00 , A61P25/00 , A61P19/10 , A61P19/02 , A61P9/00 , A61K39/00 , G01N33/53 , G06G7/48 , A01K67/027 , C12N5/10 , B05D1/00
CPC分类号： A61K38/10 , A61K9/0019 , A61K9/5021 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61K38/00 , A61K38/12 , C07K7/08 , C07K14/495 , G01N33/6872 , G01N2333/495
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
摘要翻译： 本发明一般涉及组织分化因子（TDF）类似物。 更具体地，本发明涉及用作设计，鉴定和产生作为TDF样受体的功能调节剂的分子的基于结构的方法和组合物。 本发明还涉及检测，预防和治疗TDF相关疾病的方法。
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公开(公告)号：US20140044754A1
公开(公告)日：2014-02-13
申请号：US13777658
申请日：2013-02-26
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
摘要翻译： 本发明一般涉及组织分化因子（TDF）类似物。 更具体地，本发明涉及用于设计，鉴定和产生作为TDF样受体的功能调节剂的分子的基于结构的方法和组合物。 本发明还涉及检测，预防和治疗TDF相关疾病的方法。
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公开(公告)号：US20100015150A1
公开(公告)日：2010-01-21
申请号：US11629558
申请日：2005-06-17
IPC分类号： A61K39/395 , A61K39/00 , C12Q1/68 , G01N33/53 , C12P21/00 , C12N5/10 , C12N15/63 , A61K38/17 , A61K38/04 , A61K48/00 , C07K7/06 , C07K7/08 , C07K16/00 , C07H21/00 , A01K67/027 , A61P25/00 , A61P27/00
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
摘要翻译： 本发明一般涉及组织分化因子（TDF）类似物。 更具体地，本发明涉及用于设计，鉴定和产生作为TDF样受体的功能调节剂的分子的基于结构的方法和组合物。 本发明还涉及检测，预防和治疗TDF相关疾病的方法。
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公开(公告)号：US08410246B2
公开(公告)日：2013-04-02
申请号：US11629558
申请日：2005-06-17
IPC分类号： A61K38/00
摘要： The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
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公开(公告)号：US06558649B1
公开(公告)日：2003-05-06
申请号：US09466582
申请日：1999-12-17
IPC分类号： A61K5100
CPC分类号： C07K9/003 , A61K49/0002 , A61K51/0497 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/0207 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024 , C07K7/02 , C07K7/06 , C07K7/64
摘要： The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The present invention further provides novel compounds useful for imaging atherosclerosis, restenosis, cardiac ischemia and myocardial reperfusion injury. The present invention still further provides novel compounds useful for the treatment of rheumatoid arthritis. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
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公开(公告)号：US06794109B2
公开(公告)日：2004-09-21
申请号：US09791252
申请日：2001-02-23
IPC分类号： G03F7004
CPC分类号： G03F7/0392 , G03F7/0046 , Y10S430/108 , Y10S430/115
摘要： The present invention provides photoresist materials for use in photolithography at wavelengths less than about 248 nm. More particularly, the photoresists of the invention are particularly suited for use in 157 nm lithography. A photoresist composition of the invention includes a polymer having at least one monomeric unit having an aromatic moiety. The monomeric unit further includes at least a group, such as an electron withdrawing group, attached to the aromatic moiety. The attached group includes at least one CF bond. The polymer further includes an acidic hydroxyl group. A photoresist composition of the invention can have an absorbance in a range of 1-5 &mgr;m−1 at 157 nm, rendering it particularly suitable for use as a single layer resist in 157 nm lithography.
摘要翻译： 本发明提供了在波长小于约248nm的光刻中使用的光刻胶材料。 更具体地说，本发明的光致抗蚀剂特别适用于157nm光刻。 本发明的光致抗蚀剂组合物包括具有至少一个具有芳族部分的单体单元的聚合物。 单体单元还包括至少一个与芳族部分连接的基团，例如吸电子基团。 所附组包括至少一个CF键。 聚合物还包括酸性羟基。 本发明的光致抗蚀剂组合物可以在157nm处具有在1-5mum -1的范围内的吸光度，使其特别适合用作157nm光刻中的单层抗蚀剂。
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公开(公告)号：US06548663B1
公开(公告)日：2003-04-15
申请号：US09281050
申请日：1999-03-30
申请人： Edward H Cheesman , Michael Sworin
发明人： Edward H Cheesman , Michael Sworin
IPC分类号： C07D22316
CPC分类号： C07K5/06191 , A61K49/0002 , A61K49/04 , A61K49/085 , A61K49/10 , A61K49/223 , A61K51/0497 , B01J2219/00317 , B01J2219/00495 , B01J2219/00659 , B01J2219/00707 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07K5/0205 , C07K5/0207 , C07K5/0215 , C07K5/06139 , C07K5/0806 , C07K5/0821 , C07K5/1008 , C07K5/1024 , C07K7/02 , C07K7/06 , C07K7/64 , C07K9/003 , C40B60/14
摘要： The present invention describes novel compounds of the formula: (Q)d—Ln—Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking group, and a therapeutically effective radioisotope or diagnostically effective imageable moiety. The imageable moiety is a gamma ray or positron emitting radioisotope, a magnetic resonance imaging contrast agent, an X-ray contrast agent, or an ultrasound contrast agent.
摘要翻译： 本发明描述了新的下式化合物：可用于癌症的诊断和治疗，对患者肿瘤成像的方法，以及治疗患者癌症的方法。 本发明还提供了可用于监测治疗性血管生成治疗和破坏新的血管生成脉管系统的新型化合物。 药物由与血管发生期间上调的受体结合的靶向部分，任选的连接基团和治疗有效的放射性同位素或诊断上有效的可成像部分组成。 可成像部分是伽马射线或正电子发射放射性同位素，磁共振成像造影剂，X射线造影剂或超声造影剂。
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9.发明授权Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders 失效放射性标记的血小板GPIIb / IIIa受体拮抗剂作为诊断血栓栓塞障碍的显像剂
公开(公告)号：US6022523A
公开(公告)日：2000-02-08
申请号：US999400
申请日：1997-12-29
申请人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
发明人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
IPC分类号： A61K38/12 , A61K49/04 , A61K51/00 , A61K51/04 , A61K51/08 , C07B59/00 , C07D213/82 , C07D257/00 , C07D259/00 , C07D277/60 , C07D401/00 , C07D401/12 , C07D401/14 , C07D413/12 , C07K5/10 , C07K5/103 , C07K7/64 , C07K14/75 , C07K17/02
CPC分类号： C07K14/75 , A61K51/04 , A61K51/0482 , A61K51/082 , A61K51/088 , C07B59/008 , C07D213/82 , C07D401/12 , C07D401/14 , A61K2123/00
摘要： This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.
摘要翻译： 本发明提供新的放射性药物，其是放射性标记的环状化合物，其含有作为血小板糖蛋白IIb / IIIa复合物拮抗剂的碳环或杂环系统; 使用所述放射性药物作为诊断动脉和静脉血栓的显像剂的方法; 用于制备所述放射性药物的新型试剂; 以及包含所述试剂的试剂盒。
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公开(公告)号：US5879657A
公开(公告)日：1999-03-09
申请号：US218861
申请日：1994-03-28
申请人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
发明人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
IPC分类号： A61K38/12 , A61K49/04 , A61K51/00 , A61K51/04 , A61K51/08 , C07B59/00 , C07D213/82 , C07D257/00 , C07D259/00 , C07D277/60 , C07D401/00 , C07D401/12 , C07D401/14 , C07D413/12 , C07K5/10 , C07K5/103 , C07K7/64 , C07K14/75 , C07K17/02 , A61M36/14
CPC分类号： C07K14/75 , A61K51/04 , A61K51/0482 , A61K51/082 , A61K51/088 , C07B59/008 , C07D213/82 , C07D401/12 , C07D401/14 , A61K2123/00
摘要： This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.
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