公开(公告)号：US20200208213A1

公开(公告)日：2020-07-02

申请号：US16342572

申请日：2017-10-23

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan SKOG ,  Sudipto CHAKRABORTTY ,  Dalin CHAN ,  Michael VALENTINO ,  Vasisht TADIGOTLA ,  Robert KITCHEN ,  Dominik GRIMM ,  Wei YU

IPC: C12Q1/6874 ,  G01N1/28 ,  C12N15/10 ,  G01N33/543

Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).

公开(公告)号：US20250075258A1

公开(公告)日：2025-03-06

申请号：US18579636

申请日：2022-07-18

Applicant: Exosome Diagnostics, Inc. ,  Trustees of Tufts College

Inventor： Sudipto Kumar CHAKRABORTTY ,  Steven LANG ,  Yevgenia Leona Khodor TOLAN ,  Martina RAUSCHER ,  Vasisht TADIGOTLA ,  Wei YU ,  Athena S. PAPAS ,  Johan Karl Olov SKOG ,  Brian C. HAYNES ,  Shuran XING

IPC: C12Q1/6832 ,  C12Q1/6869

Abstract: The present disclosure is directed to methods of using salivary exosomes to detect and treat Sjögren's syndrome in a subject.

公开(公告)号：US20230203587A1

公开(公告)日：2023-06-29

申请号：US17928452

申请日：2021-05-28

Applicant: Exosome Diagnostics, Inc. ,  The Brigham and Women's Hospital, Inc.

Inventor： Johan SKOG ,  Vasisht TADIGOTLA ,  James HURLEY ,  Jamil AZZI

IPC: C12Q1/6883 ,  C12Q1/686

CPC classification number: C12Q1/6883 ,  C12Q1/686 ,  C12Q2600/118 ,  C12Q2600/158

Abstract: The present disclosure relates to methods of identifying and treating kidney rejection in a subject comprising analyzing microvesicular RNA, cell-free DNA or the combination of microvesicular and cell-free DNA.”

公开(公告)号：US20200224245A1

公开(公告)日：2020-07-16

申请号：US16631603

申请日：2018-07-18

Applicant: Exosome Diagnostics, Inc.

Inventor： Robert KITCHEN ,  Michael VALENTINO ,  Johan SKOG ,  Vasisht TADIGOTLA ,  Dalin CHAN ,  Sudipto CHAKRABORTTY ,  James HURLEY

IPC: C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6886 ,  C12Q1/6851

Abstract: The present disclosure relates to methods for providing a clinical assessment of a subject in need thereof using the gene expression level measurements from exosomes derived from the subject.