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公开(公告)号：US20170296155A1
公开(公告)日：2017-10-19
申请号：US15515980
申请日：2015-09-30
Applicant: EXOSOME DIAGNOSTICS, INC.
Inventor： Johan SKOG , Bill TISEL , Joseph BAKER
CPC classification number: A61B10/007 , A61B90/90 , B01L3/50825 , B01L2200/0689 , B01L2200/087 , B01L2200/14 , B01L2200/141 , B01L2300/021 , B01L2300/042 , B01L2300/0832 , B01L2300/0851 , B01L2300/087
Abstract: In order to address an inability to separate portions of a sample and/or substance, in some embodiments, methods and apparatuses for separating components and/or portions of a sample are provided. For example, a sample collection container may comprise two areas within the container, one which is configured to contain a first volume of the sample, and one which is configured to contain a second volume of the sample. A float device may be configured to seal the portion of the container collecting the first volume from the portion of the container collecting the second volume, after the former portion of the container has been filled. The sample collection container may further comprise a top cap configured to further seal the two portions of the container, and to prevent leakage and/or spilling of the sample from the sample collection container.
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Patent Agency Ranking
2.发明公开公开(公告)号：US20230203587A1
公开(公告)日：2023-06-29
申请号：US17928452
申请日：2021-05-28
Inventor： Johan SKOG , Vasisht TADIGOTLA , James HURLEY , Jamil AZZI
IPC: C12Q1/6883 , C12Q1/686
CPC classification number: C12Q1/6883 , C12Q1/686 , C12Q2600/118 , C12Q2600/158
Abstract: The present disclosure relates to methods of identifying and treating kidney rejection in a subject comprising analyzing microvesicular RNA, cell-free DNA or the combination of microvesicular and cell-free DNA.”
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公开(公告)号：US20200208213A1
公开(公告)日：2020-07-02
申请号：US16342572
申请日：2017-10-23
Applicant: Exosome Diagnostics, Inc.
Inventor： Johan SKOG , Sudipto CHAKRABORTTY , Dalin CHAN , Michael VALENTINO , Vasisht TADIGOTLA , Robert KITCHEN , Dominik GRIMM , Wei YU
IPC: C12Q1/6874 , G01N1/28 , C12N15/10 , G01N33/543
Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).
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公开(公告)号：US20200149036A1
公开(公告)日：2020-05-14
申请号：US16473604
申请日：2018-01-02
Applicant: Exosome Diagnostics, Inc.
Inventor： Daniel ENDERLE , Johan SKOG , Phillipp TORKLER , Alexandra SPIEL , Mikkel NOERHOLM
IPC: C12N15/10 , C12Q1/6806 , C12Q1/6874
Abstract: The invention provides a series of steps to distinguish RNA from DNA in assays downstream of a combined isolation. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected.
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公开(公告)号：US20210230701A1
公开(公告)日：2021-07-29
申请号：US15734363
申请日：2019-06-06
Applicant: Exosome Diagnostics, Inc.
Inventor： Robert KITCHEN , Elena CASTELLANOS-RIZALDOS , Mia SHER , James HURLEY , Dalin CHAN , Georg STOLL , Wei YU , Johan SKOG
IPC: C12Q1/6886
Abstract: The present disclosure relates to methods for detecting and treating bladder cancer in a subject using the gene expression level measurements from exosomes derived from the subject.
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6.发明申请公开(公告)号：US20200224245A1
公开(公告)日：2020-07-16
申请号：US16631603
申请日：2018-07-18
Applicant: Exosome Diagnostics, Inc.
Inventor： Robert KITCHEN , Michael VALENTINO , Johan SKOG , Vasisht TADIGOTLA , Dalin CHAN , Sudipto CHAKRABORTTY , James HURLEY
IPC: C12Q1/686 , C12Q1/6806 , C12Q1/6886 , C12Q1/6851
Abstract: The present disclosure relates to methods for providing a clinical assessment of a subject in need thereof using the gene expression level measurements from exosomes derived from the subject.
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