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公开(公告)号:US20210230701A1
公开(公告)日:2021-07-29
申请号:US15734363
申请日:2019-06-06
Applicant: Exosome Diagnostics, Inc.
Inventor: Robert KITCHEN , Elena CASTELLANOS-RIZALDOS , Mia SHER , James HURLEY , Dalin CHAN , Georg STOLL , Wei YU , Johan SKOG
IPC: C12Q1/6886
Abstract: The present disclosure relates to methods for detecting and treating bladder cancer in a subject using the gene expression level measurements from exosomes derived from the subject.
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公开(公告)号:US20250075258A1
公开(公告)日:2025-03-06
申请号:US18579636
申请日:2022-07-18
Applicant: Exosome Diagnostics, Inc. , Trustees of Tufts College
Inventor: Sudipto Kumar CHAKRABORTTY , Steven LANG , Yevgenia Leona Khodor TOLAN , Martina RAUSCHER , Vasisht TADIGOTLA , Wei YU , Athena S. PAPAS , Johan Karl Olov SKOG , Brian C. HAYNES , Shuran XING
IPC: C12Q1/6832 , C12Q1/6869
Abstract: The present disclosure is directed to methods of using salivary exosomes to detect and treat Sjögren's syndrome in a subject.
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公开(公告)号:US20220412971A1
公开(公告)日:2022-12-29
申请号:US17761398
申请日:2020-09-18
Applicant: Exosome Diagnostics, Inc.
Inventor: Johan Karl Olov SKOG , Olubode A. OGUNLUSI , Robert Raymond KITCHEN , Douglas ROBERTS , Wei YU
IPC: G01N33/543 , C12N15/10
Abstract: The present disclosure relates to compositions, methods and kits for the isolation of extracellular vesicles. The compositions, methods and kits can comprise a high-density liquid reagent that facilitates the sequestration of extracellular vesicles bound to magnetic beads.
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公开(公告)号:US20200208213A1
公开(公告)日:2020-07-02
申请号:US16342572
申请日:2017-10-23
Applicant: Exosome Diagnostics, Inc.
Inventor: Johan SKOG , Sudipto CHAKRABORTTY , Dalin CHAN , Michael VALENTINO , Vasisht TADIGOTLA , Robert KITCHEN , Dominik GRIMM , Wei YU
IPC: C12Q1/6874 , G01N1/28 , C12N15/10 , G01N33/543
Abstract: The invention provides a series of steps that prepare nucleic acids (RNA and/or DNA) isolated from extracellular vesicles for sequencing. This enables a wide diversity of RNAs and/or DNAs, to be efficiently detected. These can then be used to identify various attributes such as gene expression, alternative splicing, and the detection of both somatic and germline mutations including single nucleotide variants (SNV) and structural variations (insertions/deletions, fusions, inversions).
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