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公开(公告)号：US20200016079A1
公开(公告)日：2020-01-16
申请号：US16583518
申请日：2019-09-26
Applicant: FUJIFILM Corporation
Inventor： Noriyuki KASAGI , Naoki YAMADA , Mikinaga MORI , Takayuki KATO , Takayuki KOBAYASHI
Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.
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公开(公告)号：US20180133676A1
公开(公告)日：2018-05-17
申请号：US15868092
申请日：2018-01-11
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO , Takashi SASAKI , Tetsu ISHIGURO
CPC classification number: B01J13/04 , A61K9/127 , A61K9/1271 , A61K9/1277 , B01D1/00 , B01D5/006 , B01F3/0807 , B01F5/10 , B01F7/0075 , B01F2003/0842 , B01F2215/0032
Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
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公开(公告)号：US20170281543A1
公开(公告)日：2017-10-05
申请号：US15625391
申请日：2017-06-16
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K31/7068 , B01F3/08 , B01F3/0807 , B01F5/0206 , B01F5/10 , B01F2215/0032 , B01J13/04 , B01J13/08 , B82Y5/00 , B82Y40/00
Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
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Patent Agency Ranking
公开(公告)号：US20170282144A1
公开(公告)日：2017-10-05
申请号：US15625020
申请日：2017-06-16
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO , Takashi SASAKI , Tetsu ISHIGURO
CPC classification number: B01J13/04 , A61K9/127 , A61K9/1271 , A61K9/1277 , B01D1/00 , B01D5/006 , B01F3/0807 , B01F5/10 , B01F7/0075 , B01F2003/0842 , B01F2215/0032
Abstract: Disclosed herein are a method for producing a liposome which is capable of reducing the facility costs and also capable of rapid desolvation, and an apparatus for producing a liposome which is for use in the above-mentioned method. Provided is a method for producing a liposome, including a stirring step of stirring a mixed liquid containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase, and an evaporating step of evaporating an organic solvent from the mixed liquid, in which the condensed organic solvent is removed by passing a gas having a temperature not higher than the dew point of the solvent in the evaporating step.
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公开(公告)号：US20230210993A1
公开(公告)日：2023-07-06
申请号：US18182733
申请日：2023-03-13
Applicant: FUJIFILM Corporation
Inventor： Naoki YAMADA , Shun Kaneumi , Keiko Suzuki , Noriyuki Kasagi , Naoto Nakamura
IPC: A61K47/18 , A61K47/28 , A61K47/24 , A61K31/7088 , A61K47/10
CPC classification number: A61K47/18 , A61K47/28 , A61K47/24 , A61K31/7088 , A61K47/10
Abstract: An object of the present invention is to provide a lipid composition capable of achieving excellent nucleic acid delivery. According to the present invention, there is provided a lipid composition containing a lipid represented by Formula (1) or a salt thereof, a nucleic acid, at least one non-cationic lipid, and a lipid represented by R51-L-(OCH2CH2)n—O-R52 (in the formula, R51 represents a hydrocarbon group having 6 to 30 carbon atoms, L represents —CO— or a single bond, R52 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and n represents an integer of 10 to 150).
In the formula, each symbol means the definition described in the description.-
公开(公告)号：US20210038518A1
公开(公告)日：2021-02-11
申请号：US17079759
申请日：2020-10-26
Applicant: FUJIFILM Corporation
Inventor： Noriyuki KASAGI , Naoki YAMADA , Mikinaga MORI , Takayuki KATO , Takayuki KOBAYASHI
Abstract: An object of the present invention is to provide a liposome composition and a pharmaceutical composition, which exhibit a high AUC. Provided are a liposome composition including a hydrophilic polymer-modified diacylphosphatidylethanolamine, a dihydrosphingomyelin, and cholesterols as components of a liposome membrane, in which the liposome composition encapsulates a drug, an inner water phase thereof contains ammonium sulfate, and a molar ratio of sulfate ions in the inner water phase to the drug in an entire water phase is 0.36 or more; and a pharmaceutical composition including the liposome composition.
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公开(公告)号：US20180296485A1
公开(公告)日：2018-10-18
申请号：US16013355
申请日：2018-06-20
Applicant: FUJIFILM Corporation
Inventor： Naoki YAMADA , Keiko MAKITA , Eriko WATANABE , Takuya INOUE
IPC: A61K9/127 , A61K47/24 , A61K47/10 , A61K31/704
Abstract: An object of the present invention is to provide a liposome and a liposome composition in which release of a drug in blood is suppressed during accumulation of the liposome and the liposome composition in a target site such as a tumor and the drug is rapidly removed after the liposome and the liposome composition are sufficiently accumulated. According to the present invention, there is provided a liposome containing at least a phospholipid to which a hydrophilic polymer is bonded, a phospholipid having a negative charge within a range of a pH of 6 to 8, and a phospholipid which is electrically neutral within a range of a pH of 6 to 8, in which an average carbon chain length of the phospholipid to which the above-described hydrophilic polymer is bonded is shorter than an average carbon chain length of the above-described phospholipid which is electrically neutral within a range of a pH of 6 to 8.
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公开(公告)号：US20180133156A1
公开(公告)日：2018-05-17
申请号：US15868160
申请日：2018-01-11
Applicant: FUJIFILM Corporation
Inventor： Susumu SUGIYAMA , Naoki YAMADA , Shigehisa SUGIYAMA , Yohei OKUBO
CPC classification number: A61K9/1277 , A61K9/127 , A61K9/1271 , A61K31/7068 , B01F3/08 , B01F3/0807 , B01F5/0206 , B01F5/10 , B01F2215/0032 , B01J13/04 , B01J13/08 , B82Y5/00 , B82Y40/00
Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
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