公开(公告)号：US5010074A

公开(公告)日：1991-04-23

申请号：US365250

申请日：1989-06-12

申请人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

发明人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/14 ,  C07D223/16 ,  C07D405/04 ,  C07D491/052 ,  C07D491/153 ,  C07D495/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D405/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl; R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represent hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or alkoxy or trifluoromethyl, or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-CH.dbd.CH--, --CH.sub.2 -CH.sub.2 -CH.sub.2 --, --CH.sub.2 -CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R.sup.13 represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.

公开(公告)号：US5025009A

公开(公告)日：1991-06-18

申请号：US477450

申请日：1990-02-07

申请人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

发明人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/14 ,  C07D223/16 ,  C07D405/04 ,  C07D491/052 ,  C07D491/153 ,  C07D495/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D405/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl;R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represents hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among--O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.dbd.CH--, --CH.sub.2, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R-- represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.