公开(公告)号：US5250538A

公开(公告)日：1993-10-05

申请号：US864734

申请日：1992-04-07

申请人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Farrup ,  John B. Hansen

发明人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Farrup ,  John B. Hansen

IPC分类号： C07D401/12 ,  C07D403/12 ,  A61K31/445

CPC分类号： C07D401/12 ,  C07D403/12

摘要： Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.

摘要翻译： 式（I）的吲哚衍生物其中R 1，R 2，R 3和R 4可以是氢或任选被卤素取代的低级烷基; A1表示含有2至4个碳原子的直链或支链亚烷基链; R5是氢或直链或支链烷基; A2是含有2至6个碳原子的直链或支链，饱和或不饱和烃链; 并且R6被选自由各种结构组成的组，已被发现显示出中枢神经系统活性。

公开(公告)号：US5126363A

公开(公告)日：1992-06-30

申请号：US645381

申请日：1991-01-23

申请人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Faarup ,  John B. Hansen

发明人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Faarup ,  John B. Hansen

IPC分类号： A61K31/40 ,  A61K31/4427 ,  A61K31/4465 ,  A61K31/45 ,  A61P43/00 ,  C07D401/12 ,  C07D403/00 ,  C07D403/12 ,  C07D491/18 ,  C07D493/08 ,  C07D495/08

CPC分类号： C07D401/12 ,  C07D403/12

摘要： Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.

摘要翻译： 式（I）的吲哚衍生物其中R 1，R 2，R 3和R 4可以是氢或任选被卤素取代的低级烷基; A1表示含有2至4个碳原子的直链或支链亚烷基链; R5是氢或直链或支链烷基; A2是含有2至6个碳原子的直链或支链，饱和或不饱和烃链; 并且R6被选自由各种结构组成的组，已被发现显示出中枢神经系统活性。

公开(公告)号：US5079243A

公开(公告)日：1992-01-07

申请号：US477284

申请日：1990-02-08

申请人： Louis B. Hansen ,  Kristian T. Hansen

发明人： Louis B. Hansen ,  Kristian T. Hansen

IPC分类号： A61K31/55 ,  A61P25/00 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

CPC分类号： C07D223/16 ,  C07D405/04

摘要： Novel 2, 3, 4, 5-tetrahydro-1H-3-benzazepines, which in the 7-position have a methoxymethyloxy group, in the 8-position hydrogen, halogen, or a nitro group and in the 5-position have an optionally substituted phenyl ortho-fused ring-system, with interesting effects on the central nervous system.

公开(公告)号：US5227488A

公开(公告)日：1993-07-13

申请号：US590393

申请日：1990-09-28

申请人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Faarup ,  John B. Hansen

发明人： Lone Jeppesen ,  Peter H. Andersen ,  Louis B. Hansen ,  Peter Faarup ,  John B. Hansen

IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/435 ,  A61P25/00 ,  A61P25/18 ,  C07D209/48 ,  C07D209/66 ,  C07D209/70 ,  C07D209/76 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D491/08 ,  C07D491/18 ,  C07D495/18

CPC分类号： C07D209/48 ,  C07D209/66 ,  C07D209/70 ,  C07D209/76 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; X represents oxygen or sulfur; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.

摘要翻译： 式（I）的吲哚衍生物其中R 1，R 2，R 3和R 4可以是氢或任选被卤素取代的低级烷基; X表示氧或硫; A1表示含有2至4个碳原子的直链或支链亚烷基链; R5是氢或直链或支链烷基; A2是含有2至6个碳原子的直链或支链，饱和或不饱和烃链; 并且R6被选自由各种结构组成的组，已被发现显示出中枢神经系统活性。

公开(公告)号：US5010074A

公开(公告)日：1991-04-23

申请号：US365250

申请日：1989-06-12

申请人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

发明人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/14 ,  C07D223/16 ,  C07D405/04 ,  C07D491/052 ,  C07D491/153 ,  C07D495/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D405/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl; R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represent hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or alkoxy or trifluoromethyl, or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-CH.dbd.CH--, --CH.sub.2 -CH.sub.2 -CH.sub.2 --, --CH.sub.2 -CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R.sup.13 represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.

公开(公告)号：US4751222A

公开(公告)日：1988-06-14

申请号：US853891

申请日：1986-04-21

申请人： Claus Braestrup ,  Peter H. Andersen ,  Poul Borrevang ,  Frederik C. Gr nvald ,  Louis B. Hansen ,  Rolf Hohlweg

发明人： Claus Braestrup ,  Peter H. Andersen ,  Poul Borrevang ,  Frederik C. Gr nvald ,  Louis B. Hansen ,  Rolf Hohlweg

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/16 ,  C07D333/00 ,  C07D401/04 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D407/02

CPC分类号： C07D223/16 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines which in the 5-position have furyl, thienyl, pyridyl, or ring systems consisting of phenyl ortho condensed with a benzen, cyclohexan, cyclohexen, cyclopentan or cyclopenten ring wherein one of the carbon atoms may be exchanged with oxygen, sulphur or nitrogen, have interesting central nervous system and cardiovascular effects.

摘要翻译： 5-位上的新的2,3,4,5-四氢-1H-3-苯并吖庚因具有呋喃基，噻吩基，吡啶基或环系，由与苯，环己烷，环己烯，环戊烷或环戊烯环原子缩合的苯基组成，其中 其中一个碳原子可以与氧，硫或氮交换，具有有趣的中枢神经系统和心血管作用。

公开(公告)号：US5025009A

公开(公告)日：1991-06-18

申请号：US477450

申请日：1990-02-07

申请人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

发明人： Frederik Gronwald ,  Peter H. Andersen ,  Peter Faarup ,  Erling Guddal ,  Kristian T. Hansen ,  Louis B. Hansen ,  Erik B. Nielsen

IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  C07D223/14 ,  C07D223/16 ,  C07D405/04 ,  C07D491/052 ,  C07D491/153 ,  C07D495/04

CPC分类号： C07D223/16 ,  C07D223/14 ,  C07D405/04

摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl;R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represents hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among--O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.dbd.CH--, --CH.sub.2, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R-- represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.