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公开(公告)号：US5010074A
公开(公告)日：1991-04-23
申请号：US365250
申请日：1989-06-12
申请人： Frederik Gronwald , Peter H. Andersen , Peter Faarup , Erling Guddal , Kristian T. Hansen , Louis B. Hansen , Erik B. Nielsen
发明人： Frederik Gronwald , Peter H. Andersen , Peter Faarup , Erling Guddal , Kristian T. Hansen , Louis B. Hansen , Erik B. Nielsen
IPC分类号： A61K31/55 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D223/14 , C07D223/16 , C07D405/04 , C07D491/052 , C07D491/153 , C07D495/04
CPC分类号： C07D223/16 , C07D223/14 , C07D405/04
摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl; R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represent hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or alkoxy or trifluoromethyl, or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O-CH.dbd.CH--, --CH.sub.2 -CH.sub.2 -CH.sub.2 --, --CH.sub.2 -CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R.sup.13 represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.
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公开(公告)号：US5025009A
公开(公告)日：1991-06-18
申请号：US477450
申请日：1990-02-07
申请人： Frederik Gronwald , Peter H. Andersen , Peter Faarup , Erling Guddal , Kristian T. Hansen , Louis B. Hansen , Erik B. Nielsen
发明人： Frederik Gronwald , Peter H. Andersen , Peter Faarup , Erling Guddal , Kristian T. Hansen , Louis B. Hansen , Erik B. Nielsen
IPC分类号： A61K31/55 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D223/14 , C07D223/16 , C07D405/04 , C07D491/052 , C07D491/153 , C07D495/04
CPC分类号： C07D223/16 , C07D223/14 , C07D405/04
摘要： Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R.sup.3 represents H, C.sub.1-3 -alkyl or C.sub.3-7 -cycloalkyl;R.sup.4 represents hydrogen or R.sup.4 together with R.sup.10 represents a bridge which connects the positions to which R.sup.4 and R.sup.10 are linked, said bridge being --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --O--CH.sub.2 -- or --S--CH.sub.2 --;R.sup.7 represents hydroxy, lower alkoxy;R.sup.10, R.sup.11, R.sup.12 independently represent hydrogen or halogen or alkyl or R.sup.10 together with R.sup.4 represents a bridge as described in connection with the definition of R.sup.4 ; or R.sup.10 together with R.sup.11 represents a bridge or R.sup.11 together with R.sup.12 represents a bridge, the bridge in both cases being chosen among--O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --CH.sub.2 --CH.sub.2 --, --O--CH.dbd.CH--, --CH.sub.2, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --;R-- represents hydrogen, halogen or lower alkyl.The compounds are useful in preparations for treatment of disorders in the central nervous system.
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3.发明授权
公开(公告)号：US5227488A
公开(公告)日：1993-07-13
申请号：US590393
申请日：1990-09-28
IPC分类号： A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/435 , A61P25/00 , A61P25/18 , C07D209/48 , C07D209/66 , C07D209/70 , C07D209/76 , C07D401/12 , C07D403/12 , C07D417/12 , C07D491/08 , C07D491/18 , C07D495/18
CPC分类号： C07D209/48 , C07D209/66 , C07D209/70 , C07D209/76 , C07D401/12 , C07D403/12 , C07D417/12
摘要： Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; X represents oxygen or sulfur; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.
摘要翻译： 式（I）的吲哚衍生物其中R 1，R 2，R 3和R 4可以是氢或任选被卤素取代的低级烷基; X表示氧或硫; A1表示含有2至4个碳原子的直链或支链亚烷基链; R5是氢或直链或支链烷基; A2是含有2至6个碳原子的直链或支链，饱和或不饱和烃链; 并且R6被选自由各种结构组成的组，已被发现显示出中枢神经系统活性。
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公开(公告)号：US5126363A
公开(公告)日：1992-06-30
申请号：US645381
申请日：1991-01-23
IPC分类号： A61K31/40 , A61K31/4427 , A61K31/4465 , A61K31/45 , A61P43/00 , C07D401/12 , C07D403/00 , C07D403/12 , C07D491/18 , C07D493/08 , C07D495/08
CPC分类号： C07D401/12 , C07D403/12
摘要： Indole derivatives of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen or lower alkyl optionally substituted by halogen; A.sup.1 represents a straight or branched alkylene chain containing from 2 to 4 carbon atoms; R.sup.5 is hydrogen or a straight or branched alkyl group; A.sup.2 is a straight or branched, saturated or unsaturated hydrocarbon chain containing from 2 to 6 carbon atoms; and R.sup.6 is selected from a group consisting of various structures, have been found to exhibit central nervous system activities.
摘要翻译： 式（I）的吲哚衍生物其中R 1，R 2，R 3和R 4可以是氢或任选被卤素取代的低级烷基; A1表示含有2至4个碳原子的直链或支链亚烷基链; R5是氢或直链或支链烷基; A2是含有2至6个碳原子的直链或支链，饱和或不饱和烃链; 并且R6被选自由各种结构组成的组，已被发现显示出中枢神经系统活性。
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公开(公告)号：US06645953B2
公开(公告)日：2003-11-11
申请号：US09878884
申请日：2001-06-11
IPC分类号： A61K3156
CPC分类号： C07J9/00 , C07J41/0016 , Y10S514/841 , Y10S514/842 , Y10S514/843
摘要： Sterol derivative compounds, structurally related to natural compounds which can be extracted from bull testes and from human follicular fluid, useful for regulating meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives.
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公开(公告)号：US5284847A
公开(公告)日：1994-02-08
申请号：US962958
申请日：1992-10-16
申请人： Anker S. Jorgensen , Peter Faarup , Erling Guddal , Lone Jeppesen
发明人： Anker S. Jorgensen , Peter Faarup , Erling Guddal , Lone Jeppesen
IPC分类号： A61K31/495 , A61P25/08 , A61P25/20 , A61P43/00 , C07D495/04 , C07D333/040 , C07D333/36
CPC分类号： C07D495/04
摘要： Novel thieno[2,3-b]pyrazine-2,3(1H,3H)-diones or tautomeric forms thereof of the formula (I) ##STR1## The compounds are useful in the treatment of neurological and psychiatric diseases.
摘要翻译： （I）的新型噻吩并[2,3-b]吡嗪-2,3（1H，3H） - 二酮或其互变异构体形式（I）该化合物可用于治疗神经和精神疾病。
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7.发明授权Process for the preparation of phosphorus derivatives of secondary ammonium salts of penam and cephem compounds 失效制备PENAM和CEPHEM化合物的次级钠盐的磷酸盐衍生物的方法
公开(公告)号：US4082745A
公开(公告)日：1978-04-04
申请号：US669048
申请日：1976-03-22
IPC分类号： C07D499/00 , C07D499/12 , C07D499/42 , C07D501/06 , C07F9/6561 , C07D499/14 , C07D501/04
CPC分类号： C07D499/00 , C07F9/65611 , C07F9/65613
摘要： An improvement in the conversion of penam and cephem compounds to secondary ammonium salts of phosphite amides thereof by reacting as follows: ##STR1## wherein --R, is the non-reacting balance of the penam or cephem compound and ##STR2## ARE NON-REACTING SUBSTITUENTS. Catalytic amounts of H--N
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公开(公告)号：US3994883A
公开(公告)日：1976-11-30
申请号：US427363
申请日：1973-12-21
IPC分类号： C07D499/00 , C07D499/12 , C07D499/42 , C07D501/06 , C07D501/18 , C07F9/6561 , C07D499/02
CPC分类号： C07D499/00 , C07F9/65611 , C07F9/65613
摘要： Novel penicillin and cephalosporin intermediates for the synthesis of 6-APA or 7-aminocephem compounds involving formation of a 6 or 7 phosphite amido compound and the conversion of such compound to a desired 6-APA or 7-aminocephem compound.
摘要翻译： 用于合成涉及形成6或7亚磷酸酰胺化合物的6-APA或7-氨基头孢烯化合物的新型青霉素和头孢菌素中间体以及将该化合物转化为所需的6-APA或7-氨基头孢烯化合物。
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9.发明授权Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines 失效取代的7-羟基-2,3,4,5-四氢-1H-3-苯并吖庚因的氨基甲酸酯
公开(公告)号：US5017571A
公开(公告)日：1991-05-21
申请号：US317016
申请日：1989-02-28
申请人： Kristian T. Hansen , Hans Bundgaard , Peter Faarup
发明人： Kristian T. Hansen , Hans Bundgaard , Peter Faarup
IPC分类号： C07D223/16 , A61K31/55 , A61P25/00 , C07D401/04 , C07D403/12 , C07D405/04 , C07D409/04
CPC分类号： C07D401/04 , C07D405/04 , C07D409/04
摘要： Compounds having the formula ##STR1## wherein R.sup.1, R.sup.4, R.sup.6, R.sup.7, and R.sup.8 are hydrogen or a substituent, R.sup.2 is a substituent, R.sup.5 is an optionally-substituted bicyclic ring system, especially a 7-benzofuranyl or 2,3-dihydrobenzofuran-7-yl substituent, R.sup.9 is hydrogen, alkyl, alkoxycarbonyl or, together with R.sup.8, forms the remainder of a heterocyclic ring, their pharmaceutically-accceptable salts, as well as their pharmaceutical compositions and use as prodrugs for compounds active for the treatment of mental disorders, are disclosed.
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公开(公告)号：US06653492B2
公开(公告)日：2003-11-25
申请号：US10141469
申请日：2002-05-01
申请人： Peter Faarup
发明人： Peter Faarup
IPC分类号： C07J900
CPC分类号： C07J9/00
摘要： Certain bile acids find use in the pharmaceutical industry. In view of the wide distribution of serious diseases such as HIV, AIDS and Bovine Spongiform Encephalopathy (BSE) it is desirable to avoid—as far as practicable—to have any components of animal origin in medicaments in order to eliminate any danger of infection. The present invention relates to a method of providing bile acids from non-animal starting materials.
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