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14 条记录 (耗时 0.023 秒)

    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
    1.
    发明申请
    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE 审中-公开
    用于抑制目标基因表达的组合物

    公开(公告)号：US20120244210A1

    公开(公告)日：2012-09-27

    申请号：US13437428

    申请日：2012-04-02

    申请人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    发明人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61P29/00 ,  A61K31/713

    CPC分类号： A61K9/0019 ,  A61K9/1271 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32

    摘要： The present invention provides a composition that comprises a lipidparticle encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the lipidparticle contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.

    摘要翻译： 本发明提供了包含包封双链核酸分子的脂质粒子的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质颗粒含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。

    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
    2.
    发明申请
    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE 审中-公开
    用于抑制目标基因表达的组合物

    公开(公告)号：US20140039034A1

    公开(公告)日：2014-02-06

    申请号：US13980139

    申请日：2011-02-02

    申请人： Fumikazu Shinohara ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    发明人： Fumikazu Shinohara ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    IPC分类号： A61K47/44

    CPC分类号： A61K47/44 ,  A61K9/1272 ,  A61K31/713 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/32

    摘要： The present invention provides a composition that comprises a lipidparticle encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the lipidparticle contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.

    摘要翻译： 本发明提供了包含包封双链核酸分子的脂质粒子的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质颗粒含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。

    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
    3.
    发明申请
    COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE 审中-公开
    用于抑制目标基因表达的组合物

    公开(公告)号：US20120207818A1

    公开(公告)日：2012-08-16

    申请号：US13348959

    申请日：2012-01-12

    申请人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    发明人： Fumikazu SHINOHARA ,  Tetsuo Yoshida ,  Hiroko Sugishita ,  Tomoyuki Naoi ,  Toshihiko Ishii ,  Junichi Enokizono

    IPC分类号： A61K9/127 ,  A61P35/00 ,  A61P29/00 ,  A61K31/7088

    CPC分类号： A61K31/713 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/1271 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2320/32 ,  C12N2310/321 ,  C12N2310/3521

    摘要： The present invention provides a composition that comprises a liposome encapsulating a double-stranded nucleic acid molecule, wherein the antisense strand is a polynucleotide of 17 to 30 bases in which a sequence is complementary to the sequence of the 17 contiguous bases of a target gene's mRNA, the sense strand is a polynucleotide of 17 to 30 bases that contains a base sequence complementary to the base sequence of bases 1 to 17 in the 5′-end to 3′-end direction of the antisense strand, and a particular amount of the sugars binding to certain bases of the antisense strand and the sense strand are deoxyribose, or ribose whose hydroxyl group at the 2′ position is substituted by a modifying group, and wherein the liposome contains a lipid bilayer membrane whose constituent component is a lipid conjugate, a fatty acid conjugate or an aliphatic hydrocarbon conjugate of a water-soluble substance.

    摘要翻译： 本发明提供一种包含包封双链核酸分子的脂质体的组合物，其中，所述反义链是17〜30个碱基的多核苷酸，其中序列与靶基因的mRNA的17个连续碱基的序列互补 有义链是17〜30个碱基的多核苷酸，其含有与反义链的5'端至3'-端方向的碱基1至17的碱基序列互补的碱基序列，特定量的 与反义链和有义链的某些碱基结合的糖是脱氧核糖或其2'位的羟基被修饰基团取代的核糖，并且其中所述脂质体含有脂质双层膜，其构成成分是脂质缀合物， 脂肪酸结合物或水溶性物质的脂族烃共轭物。

    PHARMACEUTICAL COMPOSITION
    5.
    发明申请
    PHARMACEUTICAL COMPOSITION 审中-公开
    药物组合物

    公开(公告)号：US20100098690A1

    公开(公告)日：2010-04-22

    申请号：US12529380

    申请日：2008-03-05

    申请人： Shiro Soga ,  Toshihiko Ishii ,  Takayuki Nakashima ,  Yukimasa Shiotsu ,  Shiro Akinaga

    发明人： Shiro Soga ,  Toshihiko Ishii ,  Takayuki Nakashima ,  Yukimasa Shiotsu ,  Shiro Akinaga

    IPC分类号： A61K31/122 ,  A61K31/216 ,  A61K31/135 ,  A61K31/495 ,  A61K31/445 ,  A61K31/47 ,  A61K31/5375 ,  A61K31/44 ,  A61K31/075 ,  A61K31/165 ,  A61K31/05 ,  A61K31/5377 ,  A61K39/395 ,  A61K31/4965 ,  A61P35/00

    CPC分类号： A61K31/5375 ,  A61K31/198 ,  A61K31/337 ,  A61K31/5377 ,  A61K39/39558 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition comprising a combination of an Hsp 90 family protein inhibitor and at least one compound, the said pharmaceutical composition wherein the Hsp 90 family protein inhibitor is a benozoyl compound represented by formula (I): [wherein n represents an integer of 1 to 5; R1 represents substituted or unsubstituted lower alkyl, CONR7R8 (wherein R7 and R8, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like), or the like; R2 represents substituted or unsubstituted aryl, or the like; R3 and R5, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R4 represents a hydrogen atom, hydroxy or halogen; and R6 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like], or a prodrug thereof; or a pharmaceutically acceptable salt thereof, and the like.

    摘要翻译： 本发明提供了包含Hsp90家族蛋白抑制剂和至少一种化合物的组合的药物组合物，所述药物组合物，其中Hsp 90家族蛋白抑制剂是由式（I）表示的新戊酰化合物：[其中n表示 1〜5的整数; R1表示取代或未取代的低级烷基CONR7R8（其中R7和R8可相同或不同，各自表示氢原子，取代或未取代的低级烷基等）等; R2表示取代或未取代的芳基等; R 3和R 5可以相同或不同，各自表示氢原子，取代或未取代的低级烷基等; R4表示氢原子，羟基或卤素; R6代表氢原子，卤素，取代或未取代的低级烷基等]或其前药; 或其药学上可接受的盐等。

    Process for producing rhombohedral system boron nitride
    6.
    发明授权
    Process for producing rhombohedral system boron nitride 失效
    生产菱面体系氮化硼的方法

    公开(公告)号：US4419335A

    公开(公告)日：1983-12-06

    申请号：US356784

    申请日：1982-03-10

    申请人： Toshihiko Ishii ,  Tadao Sato

    发明人： Toshihiko Ishii ,  Tadao Sato

    IPC分类号： C23C16/34 ,  C01B21/064 ,  C01B21/06

    CPC分类号： C01B21/064 ,  C01P2002/72

    摘要： Rhombohedral system boron nitride is produced by heating a boron material selected from the group consisting of boron oxide, boric acid and an oxygen-containing boron compound capable of forming boron oxide when heated, at a temperature of from 1200.degree. to 2100.degree. C. to vaporize boron oxide and reacting the vaporized boron oxide with hydrogen cyanide or cyanogen gas.

    摘要翻译： 通过在1200〜2100℃的温度下加热选自氧化硼，硼酸和能够形成氧化硼的含氧硼化合物的硼材料，在1200〜2100℃的温度下加热硼硅酸盐体系氮化硼， 蒸发氧化硼并使蒸发的氧化硼与氰化氢或氰气反应。

    Brushless motor driver
    10.
    发明授权
    Brushless motor driver 失效
    无刷电机驱动

    公开(公告)号：US4987352A

    公开(公告)日：1991-01-22

    申请号：US323393

    申请日：1989-03-14

    申请人： Toshihiko Ishii

    发明人： Toshihiko Ishii

    IPC分类号： H02P6/00 ,  H02P6/08

    CPC分类号： H02P6/085 ,  H02P6/34 ,  Y02P80/116

    摘要： In the inventive brushless motor driver, saturation voltage creating means is provided for creating a saturation voltage corresponding to a torque command, while current correcting means is provided for comparing the created saturation voltage with operating voltages of driving transistors to correct the amount of current in transistor drive control signals so that the operating voltages drop below the created saturation voltage. Thus, it is possible to drive the motor with a high efficiency and a low noise while preventing saturation of the driving transistors with respect to any torque command.