公开(公告)号：US20180263996A1

公开(公告)日：2018-09-20

申请号：US15847400

申请日：2017-12-19

Applicant: Genentech, Inc.

Inventor： Olivier RENE ,  Benjamin FAUBER ,  David VESEY ,  Paul WINSHIP ,  Tammy LADDUWAHETTY

IPC: A61K31/541 ,  A61P19/02 ,  A61P11/06 ,  A61P17/06 ,  A61P37/02 ,  A61P29/00

CPC classification number: A61K31/541 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/02 ,  C07D279/02 ,  C07D417/10

Abstract: Compounds of the formula I: or a pharmaceutical salt thereof, wherein p, s, A, R3 and Re are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

公开(公告)号：US20170001990A1

公开(公告)日：2017-01-05

申请号：US15266222

申请日：2016-09-15

Applicant: Genentech, Inc.

Inventor： Jinhua CHEN ,  Charles Z. DING ,  Peter DRAGOVICH ,  Benjamin FAUBER ,  Zhenting GAO ,  Sharada S. LABADIE ,  Kwong Wah LAI ,  Hans Edward PURKEY ,  Kirk ROBARGE ,  Binqing WEI ,  Aihe ZHOU

IPC: C07D409/14 ,  C07D401/04 ,  C07D417/04 ,  C07D491/107 ,  C07D211/86 ,  C07D417/14 ,  C07D491/048 ,  C07D405/14 ,  C07D491/08 ,  C07D498/08 ,  C07D409/04 ,  C07D413/14

CPC classification number: C07D409/14 ,  C07D211/86 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/08 ,  C07D491/048 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract translation: 本发明提供具有通式（I）的新化合物及其互变异构体及其药学上可接受的盐，其中A1，A2，A3，A4，R1，R4，R5，R6，R7和R8如本文所定义，包括化合物和 使用化合物的方法。

公开(公告)号：US20180105516A1

公开(公告)日：2018-04-19

申请号：US15847407

申请日：2017-12-19

Applicant: Genentech, Inc.

Inventor： Benjamin FAUBER ,  Emanuela GANCIA ,  Tammy LADDUWAHETTY ,  David VESEY ,  Paul WINSHIP ,  Olivier RENE

IPC: C07D417/14 ,  A61P17/06 ,  C07D417/10

CPC classification number: C07D417/14 ,  A61K31/541 ,  A61P17/06 ,  A61P19/02 ,  C07D417/10 ,  C07D417/12

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X1, X2, X3, X4, Y, Z, A, Het, R1, R2, R3, R4, R5 R6, R7, R8, R9, R10, R11, R12 and R13 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.