公开(公告)号：US10759866B2

公开(公告)日：2020-09-01

申请号：US16240592

申请日：2019-01-04

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  C07K1/14 ,  A61K39/395

Abstract: Provide herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US12145997B2

公开(公告)日：2024-11-19

申请号：US18648209

申请日：2024-04-26

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14

Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US11639395B2

公开(公告)日：2023-05-02

申请号：US17087313

申请日：2020-11-02

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14 ,  A61P5/00 ,  A61P37/02 ,  C07K14/00 ,  C07K16/32 ,  C12N1/38 ,  C07K1/22 ,  C12N5/00

Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US12173080B1

公开(公告)日：2024-12-24

申请号：US18824681

申请日：2024-09-04

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14

Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US10906986B2

公开(公告)日：2021-02-02

申请号：US16847317

申请日：2020-04-13

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  C07K1/14 ,  A61K39/395

Abstract: Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US12098211B2

公开(公告)日：2024-09-24

申请号：US18194471

申请日：2023-03-31

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  A61P5/00 ,  A61P37/02 ,  C07K1/14 ,  C07K1/22 ,  C07K14/00 ,  C07K16/32 ,  C12N1/38 ,  C12N5/00

CPC classification number: C07K16/2887 ,  A61K39/39591 ,  C07K1/14 ,  C07K2317/24

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US11999791B2

公开(公告)日：2024-06-04

申请号：US18310448

申请日：2023-05-01

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  A61P5/00 ,  A61P37/02 ,  C07K1/14 ,  C07K1/22 ,  C07K14/00 ,  C07K16/32 ,  C12N1/38 ,  C12N5/00

CPC classification number: C07K16/2887 ,  A61K39/39591 ,  C07K1/14 ,  C07K2317/24

Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US11987637B1

公开(公告)日：2024-05-21

申请号：US18410876

申请日：2024-01-11

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14

CPC classification number: C07K16/2887 ,  A61K39/39591 ,  C07K1/14 ,  C07K2317/24

Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US10808037B1

公开(公告)日：2020-10-20

申请号：US16847309

申请日：2020-04-13

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  C07K1/14 ,  A61K39/395

Abstract: Provided herein are methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

公开(公告)号：US11987638B1

公开(公告)日：2024-05-21

申请号：US18410949

申请日：2024-01-11

Applicant: Genentech, Inc.

Inventor： Yung-Hsiang Kao ,  Michael W. Laird ,  Melody Trexler Schmidt ,  Rita L. Wong ,  Daniel P. Hewitt

IPC: C07K16/28 ,  A61K39/395 ,  C07K1/14

CPC classification number: C07K16/2887 ,  A61K39/39591 ,  C07K1/14 ,  C07K2317/24

Abstract: The invention concerns methods for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.