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公开(公告)号：US20170087137A1
公开(公告)日：2017-03-30
申请号：US15374047
申请日：2016-12-09
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Wen Liu , Snahel Patel , Michael Siu
IPC: A61K31/4439 , A61K31/437 , A61K31/4545
CPC classification number: A61K31/4439 , A61K31/437 , A61K31/4545 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.
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公开(公告)号：US09365583B2
公开(公告)日：2016-06-14
申请号：US14576890
申请日：2014-12-19
Applicant: Genentech, Inc.
Inventor： Michael Siu , Anthony Estrada , Wen Liu , Joseph P. Lyssikatos , Snahel Patel , Guibai Liang , Kevin Chen
IPC: C07D491/107 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D498/04 , C07D498/10 , C07D401/04
CPC classification number: C07D491/107 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D498/04 , C07D498/10
Abstract: The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式0化合物及其各种实施方案，以及包含式0化合物及其各种实施方案的组合物。 在式0的化合物中，基团R1A，R1B，R1C，R1D，R2，R3，R4，R5和R6具有如本文所述的含义。 本发明还提供使用式0化合物和包含式0化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症的方法。
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公开(公告)号：US09550777B2
公开(公告)日：2017-01-24
申请号：US14800829
申请日：2015-07-16
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Wen Liu , Snahel Patel , Michael Siu
IPC: C07D471/04 , C07D405/14 , A61K31/4439 , C07D405/04 , A61P25/28 , C07D401/14 , A61P25/16 , C07D401/04
CPC classification number: A61K31/4439 , A61K31/437 , A61K31/4545 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 在式I化合物中，基团R 1，R 2，R 3，R 4，R 5，R 6和R 7具有如本文所述的含义。 本发明还提供了使用式I化合物和包含式（I）化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症的方法。
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公开(公告)号：US10010549B2
公开(公告)日：2018-07-03
申请号：US14927267
申请日：2015-10-29
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Liting Dong , Kevin X. Chen , Paul Gibbons , Malcolm Huestis , Terry Kellar , Wen Liu , Changyou Ma , Joseph Lyssikatos , Alan Olivero , Snahel Patel , Daniel Shore , Michael Siu
IPC: A61K31/506 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K35/30 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/18 , C07D487/08 , C07D491/08 , C07D495/08 , C07D519/00 , C07D471/08 , A61K45/06 , A61K31/5386 , A61K31/553 , C07D417/14 , C07D487/14 , C07D487/18 , A61K31/444
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.
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Patent Agency Ranking
公开(公告)号：US11129832B2
公开(公告)日：2021-09-28
申请号：US16666273
申请日：2019-10-28
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Liting Dong , Kevin X. Chen , Paul Gibbons , Malcolm Huestis , Terry Kellar , Wen Liu , Changyou Ma , Joseph P. Lyssikatos , Alan G. Olivero , Snahel Patel , Daniel Shore , Michael Siu
IPC: C07D471/08 , A61K31/506 , A61K45/06 , A61K31/5386 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K35/30 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/18 , C07D487/08 , C07D491/08 , C07D495/08 , C07D519/00 , A61K31/553 , C07D417/14 , C07D487/14 , C07D487/18 , A61K31/444
Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.
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公开(公告)号：US10028942B2
公开(公告)日：2018-07-24
申请号：US15374047
申请日：2016-12-09
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Wen Liu , Snahel Patel , Michael Siu
IPC: A61K31/4439 , A61K31/437 , A61K31/4545
Abstract: The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.
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公开(公告)号：US20180133219A1
公开(公告)日：2018-05-17
申请号：US15868301
申请日：2018-01-11
Applicant: Genentech, Inc.
Inventor： Anthony Estrada , Liting Dong , Kevin X. Chen , Paul Gibbons , Malcolm Huestis , Terry Kellar , Wen Liu , Changyou Ma , Joseph Lyssikatos , Alan Olivero , Snahel Patel , Daniel Shore , Michael Siu
IPC: A61K31/506 , A61K31/444 , A61K35/30 , C07D487/14 , A61K31/553 , C07D417/14 , C07D487/18 , A61K31/55 , C07D401/14 , A61K31/5377 , C07D495/08 , A61K31/4545 , C07D519/00 , A61K31/5386 , A61K45/06 , C07D471/08 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D471/18 , C07D487/08 , C07D491/08
CPC classification number: A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/5386 , A61K31/55 , A61K31/553 , A61K35/30 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/14 , C07D487/18 , C07D491/08 , C07D495/08 , C07D519/00 , A61K2300/00
Abstract: The present invention provides for compounds of Formula I-I and embodiments and salts thereof for the treatment of diseases (e.g., neurodegenerative diseases). R1, R2, R3, X1, X2, A and Cy variable in Formula I-I all have the meaning as defined herein.
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公开(公告)号：US20160002228A1
公开(公告)日：2016-01-07
申请号：US14800829
申请日：2015-07-16
Applicant: Genentech, Inc.
Inventor： Anthony ESTRADA , Wen Liu , Snahel Patel , Michael Siu
IPC: C07D471/04 , C07D405/14 , C07D401/14
CPC classification number: A61K31/4439 , A61K31/437 , A61K31/4545 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: The present invention provides for compounds of Formula (I) and various embodiments thereof, and compositions comprising compounds of Formula (I) and various embodiments thereof. In compounds of Formula I, the groups R1, R2, R3, R4, R5, R6 and R7 have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula (I) as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式（I）化合物及其各种实施方案，以及包含式（I）化合物及其各种实施方案的组合物。 在式I化合物中，基团R 1，R 2，R 3，R 4，R 5，R 6和R 7具有如本文所述的含义。 本发明还提供了使用式I化合物和包含式（I）化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症的方法。
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公开(公告)号：US20150175619A1
公开(公告)日：2015-06-25
申请号：US14576890
申请日：2014-12-19
Applicant: Genentech, Inc.
Inventor： Michael Siu , Anthony Estrada , Wen Liu , Joseph P. Lyssikatos , Snahel Patel , Guibai Liang , Kevin Chen
IPC: C07D491/107 , C07D401/04 , C07D491/08 , C07D471/04 , C07D401/14 , C07D413/14 , C07D407/14
CPC classification number: C07D491/107 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/08 , C07D498/04 , C07D498/10
Abstract: The present invention provides for compounds of formula 0 and various embodiments thereof, and compositions comprising compounds of formula 0 and various embodiments thereof. In compounds of formula 0, the groups R1A, R1B, R1C, R1D, R2, R3, R4, R5 and R6 have the meaning as described herein. The present invention also provides for methods of using compounds of formula 0 and compositions comprising compounds of formula 0 as DLK inhibitors and for treating neurodegeneration diseases and disorders.
Abstract translation: 本发明提供式0化合物及其各种实施方案，以及包含式0化合物及其各种实施方案的组合物。 在式0的化合物中，基团R1A，R1B，R1C，R1D，R2，R3，R4，R5和R6具有如本文所述的含义。 本发明还提供使用式0化合物和包含式0化合物的组合物作为DLK抑制剂并用于治疗神经变性疾病和病症的方法。
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