专利检索 ap:("Gurdip BHALAY" OR "Emma BUDD" OR "Graham Charles BLOOMFIELD" OR "Stephen Paul COLLINGWOOD" OR "Andrew DUNSTAN" OR "Lee EDWARDS" OR "Peter GEDECK" OR "Catherine HOWSHAM" OR "Peter HUNT" OR "Thomas Anthony HUNT" OR "Paul OAKLEY" OR "Nichola SMITH") AND inv:"Graham Charles BLOOMFIELD" 第 1 页

1.

发明申请
ORGANIC COMPOUNDS 有权
标题翻译：有机化合物

公开(公告)号：US20130012500A1

公开(公告)日：2013-01-10

申请号：US13613495

申请日：2012-09-13

申请人： Gurdip BHALAY , Emma BUDD , Graham Charles BLOOMFIELD , Stephen Paul COLLINGWOOD , Andrew DUNSTAN , Lee EDWARDS , Peter GEDECK , Catherine HOWSHAM , Peter HUNT , Thomas Anthony HUNT , Paul OAKLEY , Nichola SMITH

发明人： Gurdip BHALAY , Emma BUDD , Graham Charles BLOOMFIELD , Stephen Paul COLLINGWOOD , Andrew DUNSTAN , Lee EDWARDS , Peter GEDECK , Catherine HOWSHAM , Peter HUNT , Thomas Anthony HUNT , Paul OAKLEY , Nichola SMITH

IPC分类号： C07D403/12 , C07D471/10 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P11/00 , A61P11/08 , A61P11/06 , A61P35/00 , A61P27/02 , A61K31/497 , A61K31/551

CPC分类号： C07D519/00 , A61K31/497 , C07D403/12 , C07D471/04 , C07D471/10 , C07D471/20 , C07D473/34 , C07D487/04 , C07D487/10

摘要： A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

摘要翻译： 式Ⅰ化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10和R11具有说明书中所述的含义，可用于治疗疾病，对上皮钠通道的阻断作出反应。还描述了含有化合物的药物组合物和用于制备化合物的方法。

2.

发明申请
TREATING DISEASES MEDIATED BY BLOCKADE OF THE EPITHELIAL SODIUM CHANNEL WITH PYRAZINE-2-CARBOXAMIDE DERIVATIVES 审中-公开
标题翻译：用吡嗪-2-羧酰胺衍生物治疗由上皮细胞通道引起的疾病

公开(公告)号：US20160068546A1

公开(公告)日：2016-03-10

申请号：US14847262

申请日：2015-09-08

申请人： Gurdip BHALAY , Emma BUDD , Graham Charles BLOOMFIELD , Stephen Paul COLLINGWOOD , Andrew DUNSTAN , Lee EDWARDS , Peter GEDECK , Catherine HOWSHAM , Peter HUNT , Thomas Anthony HUNT , Paul OAKLEY , Nichola SMITH

发明人： Gurdip BHALAY , Emma BUDD , Graham Charles BLOOMFIELD , Stephen Paul COLLINGWOOD , Andrew DUNSTAN , Lee EDWARDS , Peter GEDECK , Catherine HOWSHAM , Peter HUNT , Thomas Anthony HUNT , Paul OAKLEY , Nichola SMITH

IPC分类号： C07D519/00 , A61K31/497

CPC分类号： C07D519/00 , A61K31/497 , C07D403/12 , C07D471/04 , C07D471/10 , C07D471/20 , C07D473/34 , C07D487/04 , C07D487/10

摘要： A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

摘要翻译： 式Ⅰ化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10和R11具有说明书中所述的含义，可用于治疗疾病，对上皮钠通道的阻断作出反应。还描述了含有化合物的药物组合物和用于制备化合物的方法。

3.

发明申请
TRICYCLIC COMPOUNDS 有权
标题翻译：三聚体化合物

公开(公告)号：US20140171412A1

公开(公告)日：2014-06-19

申请号：US14109927

申请日：2013-12-17

申请人： Mahbub AHMED , Alexander ASHALL-KELLY , Graham Charles BLOOMFIELD , Louisa GUERITZ , Jeffrey MCKENNA , Joseph MCKENNA , Simon MUTTON , Rakesh PARMAR , Jon SHEPERD , Paul WRIGHT

发明人： Mahbub AHMED , Alexander ASHALL-KELLY , Graham Charles BLOOMFIELD , Louisa GUERITZ , Jeffrey MCKENNA , Joseph MCKENNA , Simon MUTTON , Rakesh PARMAR , Jon SHEPERD , Paul WRIGHT

IPC分类号： C07D487/14 , A61K45/06 , A61K31/5383 , A61K31/553 , A61K31/519 , C07D498/14

CPC分类号： C07D487/14 , A61K31/519 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D498/14

摘要： The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐; 及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。