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1.发明申请公开(公告)号：US20170042889A1
公开(公告)日：2017-02-16
申请号：US15303868
申请日：2014-04-24
申请人： Benjamin Richard BELLENIE , Graham Charles BLOOMFIELD , Ian BRUCE , Andrew James CULSHAW , Edward Charles HALL , Gregory John HOLLINGWORTH , James NEEF , Matthew SPENDIFF , Simon James WATSON
发明人： Benjamin Richard BELLENIE , Graham Charles BLOOMFIELD , Ian BRUCE , Andrew James CULSHAW , Edward Charles HALL , Gregory John HOLLINGWORTH , James NEEF , Matthew SPENDIFF , Simon James WATSON
IPC分类号： A61K31/497 , C07D413/14 , C07D403/04 , C07D417/04 , C07D401/04 , C07D409/14 , C07D403/14 , C07D409/04 , A61K31/5377 , C07D405/04 , C07D417/14 , C07D401/14 , C07D413/04 , C07D405/14
CPC分类号： A61K31/497 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
摘要翻译： 本发明提供抑制PI 3激酶γ同种型活性的式（I）化合物，其可用于治疗由PI3激酶γ同种型激活介导的疾病。
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公开(公告)号：US20140213594A1
公开(公告)日：2014-07-31
申请号：US14242434
申请日：2014-04-01
IPC分类号： C07D413/12 , C07D213/52 , C07D307/14 , C07D333/36 , C07D307/52 , C07C311/48 , C07D241/12 , C07D231/12
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 本发明涉及其中X，R 1，R 2，R 3，R 4和R 5如本文所定义的式（I）化合物，其可用于治疗对CXCR2受体介体作出反应的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US08470848B2
公开(公告)日：2013-06-25
申请号：US12699686
申请日：2010-02-03
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书 制备方法，以及作为药物的用途。
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公开(公告)号：US20130005735A1
公开(公告)日：2013-01-03
申请号：US13611446
申请日：2012-09-12
IPC分类号： A61K31/21 , A61K31/341 , C07C303/40 , C07C311/48 , C07D333/22 , A61K31/381 , C07D241/12 , A61K31/4965 , C07D213/50 , A61K31/4402 , C07D413/12 , A61K31/4439 , A61K31/422 , A61K31/4406 , A61K31/4409 , C07D231/12 , A61K31/415 , A61P29/00 , A61P37/08 , A61P11/00 , C07D307/52
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 本发明涉及其中X，R 1，R 2，R 3，R 4和R 5如本文所定义的式（I）化合物，其可用于治疗对CXCR2受体介体作出反应的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US07989497B2
公开(公告)日：2011-08-02
申请号：US12512609
申请日：2009-07-30
IPC分类号： A61K31/18
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
摘要： The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4 and R5 are as defined herein, which are useful for treating diseases which respond to CXCR2 receptor mediators. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译： 本发明涉及其中X，R 1，R 2，R 3，R 4和R 5如本文所定义的式（I）化合物，其可用于治疗对CXCR2受体介体作出反应的疾病。 还描述了含有化合物的药物组合物和用于制备化合物的方法。
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公开(公告)号：US20100204225A1
公开(公告)日：2010-08-12
申请号：US12699686
申请日：2010-02-03
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： A61K31/5377 , A61K31/437 , A61P29/00 , A61P11/08 , A61P11/14
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如说明书 制备方法，以及作为药物的用途。
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公开(公告)号：US20100125071A1
公开(公告)日：2010-05-20
申请号：US12451876
申请日：2008-06-04
IPC分类号： A61K31/5355 , C07D307/04 , C07D413/12 , C07D405/08 , A61K31/34 , A61K31/497 , A61P37/06 , C07D333/00 , A61K31/38
CPC分类号： C07D207/09 , C07D307/14
摘要： The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof.
摘要翻译： 本发明涉及具有本文定义的取代基的式（I）化合物及其用途。
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公开(公告)号：US07666878B2
公开(公告)日：2010-02-23
申请号：US11597781
申请日：2005-06-16
申请人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
发明人： Kamlesh Jagdis Bala , Catherine Leblanc , David Andrew Sandham , Katharine Louise Turner , Simon James Watson , Lyndon Nigel Brown , Brian Cox
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , A61K31/437 , A61K45/06
摘要： There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R 4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.
摘要翻译： 根据本发明，提供游离或盐形式的式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，Q，W，X，m，n和p如 规格，制备方法及其作为药物的用途。
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公开(公告)号：US20080312322A1
公开(公告)日：2008-12-18
申请号：US11915091
申请日：2006-05-22
申请人： Urs Baettig , Brian Cox , Katharine Louise Turner , Simon James Watson , Diana Janus , Catherine Leblanc , David Andrew Sandham
发明人： Urs Baettig , Brian Cox , Katharine Louise Turner , Simon James Watson , Diana Janus , Catherine Leblanc , David Andrew Sandham
CPC分类号： C07C317/22 , C07C59/70 , C07C69/712 , C07C205/37 , C07C235/22 , C07C323/20 , C07C2601/02
摘要： A compound of formula (I); in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, m, n, w, X, Y and Q have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.
摘要翻译： 式（I）化合物; 其中R 1，R 2，R 3，R 4，R 5，m，n，w，X，Y和Q具有如说明书中所示的含义，可用于治疗CRTh2受体介导的病症， 特别是炎性或阻塞性气道疾病。
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公开(公告)号：US10112926B2
公开(公告)日：2018-10-30
申请号：US15303879
申请日：2014-04-24
申请人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
发明人： Benjamin Richard Bellenie , Graham Charles Bloomfield , Ian Bruce , Andrew James Culshaw , Edward Charles Hall , Gregory John Hollingworth , James Neef , Matthew Spendiff , Simon James Watson
IPC分类号： C07D401/14 , C07D413/14 , C07D401/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D213/73 , C07D491/107 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
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