公开(公告)号：US09226731B2

公开(公告)日：2016-01-05

申请号：US13224218

申请日：2011-09-01

申请人： Hanli Liu ,  Vikrant Sharma

发明人： Hanli Liu ,  Vikrant Sharma

IPC分类号： A61B10/02 ,  A61B8/08 ,  A61B8/12 ,  A61B5/00

CPC分类号： A61B10/0241 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4887 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/12

摘要： The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement.

摘要翻译： 本发明包括用于通过光学活检检测组织例如癌症的装置，系统和方法，包括：电动计算机控制的探针支架; 连接到由电动计算机控制的探针支架控制的针状探针，该探针包括光学和超声波检测器; 以及能够进行宽带光反射光谱，自动荧光寿命测量和自动荧光光谱测量的一个或多个检测器单元。

公开(公告)号：US20110319759A1

公开(公告)日：2011-12-29

申请号：US13224218

申请日：2011-09-01

申请人： Hanli Liu ,  Vikrant Sharma

发明人： Hanli Liu ,  Vikrant Sharma

IPC分类号： A61B8/00 ,  A61B10/02

CPC分类号： A61B10/0241 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4887 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/12

摘要： The present invention includes an apparatus, system and method for detection of tissues, e.g., a cancer, by optical biopsy comprising: a motorized computer-controlled probe holder; a needle-like probe connected to and controlled by the motorized computer-controlled probe holder, the probe comprising an optical and an ultrasound detector; and one or more detector units capable of a broadband light reflectance spectroscopy, an auto fluorescence lifetime measurement, and auto fluorescence spectroscopy measurement.

摘要翻译： 本发明包括用于通过光学活检检测组织例如癌症的装置，系统和方法，包括：电动计算机控制的探针支架; 连接到由电动计算机控制的探针支架控制的针状探针，该探针包括光学和超声波检测器; 以及能够进行宽带光反射光谱，自动荧光寿命测量和自动荧光光谱测量的一个或多个检测器单元。

公开(公告)号：US06567690B2

公开(公告)日：2003-05-20

申请号：US09847997

申请日：2001-05-03

申请人： Cole Giller ,  Hanli Liu

发明人： Cole Giller ,  Hanli Liu

IPC分类号： A61B600

CPC分类号： A61B1/00147 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/04001 ,  A61B5/064 ,  A61B5/743

摘要： Method and apparatus for probe localization in brain matter. A method is disclosed for determining the insertion point for an object at a desired location within tissue of varying types. The parameters of tissue are first measured at an entry point into the tissue from exterior thereof. The parameters of the tissue are then measured periodically along a line extending from the entry point and moving away therefrom. A determination is then made if at least one boundary between tissue types has occurred during the measurement process. The measurements along the line are then compared to a predetermined map of the tissue boundaries. Thereafter, a point on the map is then selected corresponding to the desired location within the tissue when the measured parameters indicate that the measurements are taking place in proximity thereto.

公开(公告)号：US08649849B2

公开(公告)日：2014-02-11

申请号：US12600975

申请日：2008-05-21

申请人： Hanli Liu ,  Jeffrey A. Cadeddu ,  Disha L. Peswani

发明人： Hanli Liu ,  Jeffrey A. Cadeddu ,  Disha L. Peswani

IPC分类号： A61B6/00

CPC分类号： A61B5/4381 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086

摘要： The present invention includes using optical spectroscopy as an innovative technique for ex-vivo demonstration of renal and prostate tumors. The apparatus and methods disclosed herein demonstrate the ability of optical spectroscopy to reliably differentiate tumor from normal tissue in renal specimens.

摘要翻译： 本发明包括使用光谱作为用于肾和前列腺肿瘤的体外演示的创新技术。 本文公开的装置和方法证明了光谱学可靠地将肿瘤与肾脏标本中的正常组织区分开的能力。

公开(公告)号：US06957094B2

公开(公告)日：2005-10-18

申请号：US10299598

申请日：2002-11-19

申请人： Britton Chance ,  Hanli Liu

发明人： Britton Chance ,  Hanli Liu

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/6824 ,  A61B2562/0242

摘要： This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).

摘要翻译： 本发明是用于监测生物系统中的溶质的方案，包括以下步骤：将光输送到包含溶质的生物系统（12）中，所述光的波长选择在一定范围内，其中溶质基本上不吸收; 检测所传送的光的至少第一和第二部分，所述第一部分沿着一个或多个路径行进通过所述生物系统，其特征在于具有第一平均路径长度，并且所述第二部分沿着一个或多个路径行进通过所述生物系统，其特征在于， 通过大于第一平均路径长度的第二平均路径长度; 以及比较所输送的光的第一和第二部分以监测生物系统中溶质的浓度。 还描述了用于监测低分子量多羟基溶质，通常为糖（甘露醇，果糖，蔗糖，葡萄糖，山梨糖醇），醇（甲醇，乙醇，丙二醇）和电解质（钠，钾，镁，钙和氯离子） 。

公开(公告)号：USD1022473S1

公开(公告)日：2024-04-16

申请号：US29920304

申请日：2023-12-08

申请人： Hanli Liu

设计人： Hanli Liu

摘要： FIG. 1 is a front, right and top perspective view of a toothbrush head, showing my design.
FIG. 2 is a rear, left and bottom perspective view thereof.
FIG. 3 is a front elevation view thereof.
FIG. 4 is a rear elevation view thereof.
FIG. 5 is a left side elevation view thereof.
FIG. 6 is a right side elevation view thereof.
FIG. 7 is a top plan view thereof; and,
FIG. 8 is a bottom plan view thereof.
The broken lines depict portions of the toothbrush head that form no part of the claimed design.

公开(公告)号：US20060149142A1

公开(公告)日：2006-07-06

申请号：US11251565

申请日：2005-10-14

申请人： Britton Chance ,  Hanli Liu

发明人： Britton Chance ,  Hanli Liu

IPC分类号： A61B5/00 ,  A61B6/00

CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/6824 ,  A61B2562/0242

摘要： This invention is a scheme for monitoring a solute in a biological system comprising the steps of delivering light into a biological system (12) containing a solute, the light having a wavelength selected to be in a range wherein the solute is substantially non-absorbing; detecting at least first and second portions of the delivered light, the first portion having traveled through the biological system along one or more paths characterized by a first average path length, and the second portion having traveled through the biological system along one or more paths characterized by a second average path length that is greater than the first average path length; and comparing the first and second portions of the delivered light to monitor concentration of the solute in the biological system. Also described are schemes for monitoring low molecular weight polyhydroxy solutes, generally sugars (mannitol, fructose, sucrose, glucose, sorbitol), alcohols (methanol, ethanol, propanediol), and electrolytes (sodium, potassium, magnesium, calcium, and chloride ions).

摘要翻译： 本发明是用于监测生物系统中的溶质的方案，包括以下步骤：将光输送到包含溶质的生物系统（12）中，所述光的波长选择在一定范围内，其中溶质基本上不吸收; 检测所传送的光的至少第一和第二部分，所述第一部分沿着一个或多个路径行进通过所述生物系统，其特征在于具有第一平均路径长度，并且所述第二部分沿着一个或多个路径行进通过所述生物系统，其特征在于， 通过大于第一平均路径长度的第二平均路径长度; 以及比较所输送的光的第一和第二部分以监测生物系统中溶质的浓度。 还描述了用于监测低分子量多羟基溶质，通常为糖（甘露醇，果糖，蔗糖，葡萄糖，山梨糖醇），醇（甲醇，乙醇，丙二醇）和电解质（钠，钾，镁，钙和氯离子） 。

公开(公告)号：US20100198080A1

公开(公告)日：2010-08-05

申请号：US12600975

申请日：2008-05-21

申请人： Hanli Liu ,  Jeffrey A. Cadeddu ,  Disha L. Peswani

发明人： Hanli Liu ,  Jeffrey A. Cadeddu ,  Disha L. Peswani

IPC分类号： A61B6/12 ,  G06N5/02

CPC分类号： A61B5/4381 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086

摘要： The present invention includes using optical spectroscopy as an innovative technique for ex-vivo demonstration of renal and prostate tumors. The apparatus and methods disclosed herein demonstrate the ability of optical spectroscopy to reliably differentiate tumor from normal tissue in renal specimens.

摘要翻译： 本发明包括使用光谱作为用于肾和前列腺肿瘤的体外演示的创新技术。 本文公开的装置和方法证明了光谱学可靠地将肿瘤与肾脏标本中的正常组织区分开的能力。

公开(公告)号：US20100160791A1

公开(公告)日：2010-06-24

申请号：US12600981

申请日：2008-05-21

申请人： Hanli Liu ,  Edward Livingston ,  Bo Ping Wang

发明人： Hanli Liu ,  Edward Livingston ,  Bo Ping Wang

IPC分类号： A61B6/00

CPC分类号： A61B5/0059 ,  G01N21/359 ,  G01N21/4795

摘要： The present invention includes apparatus and method to prevent surgical injury. The invention incorporates near infrared (NIR) spectroscopy, which capitalizes on near infrared light's ability to penetrate deeply into tissues and spectroscopic capability to discern tissue's chemical properties. The present invention further characterized the NIR optical properties of bile containing structures as a clinically useful probe.

摘要翻译： 本发明包括防止手术损伤的装置和方法。 本发明包括近红外（NIR）光谱，其利用近红外光的深度渗透到组织中的能力和光谱能力来辨别组织的化学性质。 本发明进一步表征了胆汁含有结构的NIR光学性质作为临床有用的探针。

公开(公告)号：US20060264760A1

公开(公告)日：2006-11-23

申请号：US11352018

申请日：2006-02-10

申请人： Hanli Liu ,  Thomas Truelson

发明人： Hanli Liu ,  Thomas Truelson

IPC分类号： A61B6/00

CPC分类号： A61B5/4381 ,  A61B5/0075 ,  A61B5/0086

摘要： A multi-channel, near infrared (NIR) imaging system comprising one or more optical fiber bundles; and a transrectal NIR probe having an outer material, wherein the optical fiber bundle is integrated into the transrectal probe (an end-fire or a side-fire NIR probe). The outer material is preferably rubber-like silicon or made of two translucent materials exhibiting low viscosity and requires curing at room temperature. The transrectal NIR probe comprises a curvature to match the curvature of a human rectum and may have a circular or oval-shaped silicone holder. The imaging system further comprises a broad-band light source adapted to deliver light to the fiber channels, an optical switch box adapted to allow only one of the fiber channels to pass through at a time; and a multi-channel spectrometer to capture tomographic images of changes in HbO, HbT, light scattering patterns and hemodynamic response times from human prostate.

摘要翻译： 包括一个或多个光纤束的多通道近红外（NIR）成像系统; 以及具有外部材料的经直肠NIR探针，其中所述光纤束集成到经直肠探针（终末或侧火NIR探针）中。 外部材料优选为橡胶状硅，或由表现出低粘度的两种半透明材料制成，并且需要在室温下固化。 经直肠NIR探针包括与人直肠的曲率匹配的曲率，并且可以具有圆形或椭圆形的硅树脂保持器。 所述成像系统还包括适于将光传送到所述光纤通道的宽带光源，适于仅允许所述光纤通道中的一个一次通过的光开关盒; 和多通道光谱仪，用于捕获人类前列腺的HbO，HbT，光散射图案和血液动力学响应时间变化的断层图像。