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    Implantable device for controlled drug delivery
    1.
    发明授权
    Implantable device for controlled drug delivery 有权
    用于受控药物输送的可植入装置

    公开(公告)号：US09017312B2

    公开(公告)日：2015-04-28

    申请号：US12851494

    申请日：2010-08-05

    申请人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

    发明人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

    IPC分类号： A61K9/22 ,  A61M31/00 ,  A61K9/00 ,  A61K31/167

    CPC分类号： A61K9/0092 ,  A61K9/0004 ,  A61K9/0034 ,  A61K31/167 ,  A61M31/002

    摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.

    摘要翻译： 提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。 在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。 在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

    Implantable Device for Controlled Drug Delivery
    4.
    发明申请
    Implantable Device for Controlled Drug Delivery 有权
    用于控制药物输送的可植入装置

    公开(公告)号：US20110060309A1

    公开(公告)日：2011-03-10

    申请号：US12851494

    申请日：2010-08-05

    申请人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

    发明人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

    IPC分类号： A61M25/00 ,  A61F2/00 ,  A61K31/16

    CPC分类号： A61K9/0092 ,  A61K9/0004 ,  A61K9/0034 ,  A61K31/167 ,  A61M31/002

    摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.

    摘要翻译： 提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。 在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。 在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

    Time-selective bioresorbable or collapsible drug delivery systems and methods
    5.
    发明授权
    Time-selective bioresorbable or collapsible drug delivery systems and methods 有权
    时间选择性生物可吸收或可折叠药物递送系统和方法

    公开(公告)号：US08690840B2

    公开(公告)日：2014-04-08

    申请号：US13267560

    申请日：2011-10-06

    申请人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

    发明人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0039 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.

    摘要翻译： 提供了可植入的医疗装置和治疗方法，特别用于膀胱。 该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。 该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。

    TIME-SELECTIVE BIORESORBABLE OR COLLAPSIBLE DRUG DELIVERY SYSTEMS AND METHODS
    6.
    发明申请
    TIME-SELECTIVE BIORESORBABLE OR COLLAPSIBLE DRUG DELIVERY SYSTEMS AND METHODS 有权
    时间选择性生物可降解或可溶性药物递送系统和方法

    公开(公告)号：US20120089122A1

    公开(公告)日：2012-04-12

    申请号：US13267560

    申请日：2011-10-06

    申请人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Geising ,  Jessica K. Anderson ,  Sarma Duddu

    发明人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Geising ,  Jessica K. Anderson ,  Sarma Duddu

    IPC分类号： A61M25/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0039 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.

    摘要翻译： 提供了可植入的医疗装置和治疗方法，特别用于膀胱。 该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。 该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。