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公开(公告)号：US20080090801A1
公开(公告)日：2008-04-17
申请号：US11854999
申请日：2007-09-13
申请人： Hengmiao Cheng , Dilip Bhumralkar , Klaus Dress , Jacqui Hoffman , Mary Johnson , Robert Kania , Phuong Le , Mitchell Nambu , Mason Pairish , Michael Plewe , Khanh Tran
发明人： Hengmiao Cheng , Dilip Bhumralkar , Klaus Dress , Jacqui Hoffman , Mary Johnson , Robert Kania , Phuong Le , Mitchell Nambu , Mason Pairish , Michael Plewe , Khanh Tran
IPC分类号： A61K31/519 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα).
摘要翻译： 本发明涉及式（I）的新颖的4-甲基吡啶并嘧啶酮化合物及其盐，它们的合成及其作为磷酸肌醇3-激酶α（PI3-Kalpha）抑制剂的用途。
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公开(公告)号：US20050009840A1
公开(公告)日：2005-01-13
申请号：US10786610
申请日：2004-02-26
申请人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： A61K20060101 , A61K31/44 , A61K31/496 , A61K31/4965 , A61K31/497 , C07D20060101 , C07D211/72 , C07D213/73 , C07D401/00 , C07D401/12 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D413/12 , C07D417/00 , C07D419/00 , C07
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译： 提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。 优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂。
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公开(公告)号：US20070072874A1
公开(公告)日：2007-03-29
申请号：US11598765
申请日：2006-11-14
申请人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
发明人： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC分类号： A61K31/4965 , A61K31/497 , A61K31/4439 , A61K31/4412 , C07D403/02
CPC分类号： C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
摘要： Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
摘要翻译： 提供式（
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4.发明申请Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors 有权对映异构纯氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US20060046991A1
公开(公告)日：2006-03-02
申请号：US11212331
申请日：2005-08-26
申请人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/4965 , C07D213/72 , C07D241/20
CPC分类号： C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
摘要： Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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公开(公告)号：US20060178374A1
公开(公告)日：2006-08-10
申请号：US11213038
申请日：2005-08-26
申请人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D213/76 , C07D241/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08
摘要： Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供了氨基杂芳基化合物，以及它们的合成和使用方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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6.发明申请Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors 审中-公开吡唑取代的氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US20060128724A1
公开(公告)日：2006-06-15
申请号：US11213039
申请日：2005-08-26
申请人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
发明人： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC分类号： A61K31/496 , A61K31/4439 , C07D403/02
CPC分类号： C07D401/14 , C07D401/04
摘要： Compounds of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
摘要翻译： 提供式1的化合物，以及其合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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公开(公告)号：US20070167497A1
公开(公告)日：2007-07-19
申请号：US11621410
申请日：2007-01-09
申请人： Mitchell Nambu , Leena Patel , Brian Patterson , Sylvie Sakata , John Tatlock
发明人： Mitchell Nambu , Leena Patel , Brian Patterson , Sylvie Sakata , John Tatlock
IPC分类号： A61K31/44
CPC分类号： C07D213/76 , C07D401/12 , C07D405/12 , C07D413/12 , C07D471/10 , C07D487/08
摘要： The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐或溶剂化物，其制备方法，其使用方法和包含它们的药物制剂。
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公开(公告)号：US20110269740A1
公开(公告)日：2011-11-03
申请号：US13000606
申请日：2009-07-02
申请人： Sunny Abraham , Qi Chao , Michael Hadd , Mark Holladay , Gang Liu , Mitchell Nambu , Eduardo Setti
发明人： Sunny Abraham , Qi Chao , Michael Hadd , Mark Holladay , Gang Liu , Mitchell Nambu , Eduardo Setti
IPC分类号： A61K31/53 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P37/06 , A61P17/02 , A61P3/10 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04
摘要： Provided herein are pyrrolotriazine compounds for treatment of JAK kinase, including JAK2 kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
摘要翻译： 本文提供了用于治疗JAK激酶的吡咯并三嗪化合物，包括JAK2激酶介导的疾病。 还提供了包含该化合物的药物组合物和使用该化合物和组合物的方法。
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