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公开(公告)号：US20060178374A1
公开(公告)日：2006-08-10
申请号：US11213038
申请日：2005-08-26
Applicant: Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
Inventor： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC: A61K31/506 , C07D403/04
CPC classification number: C07D213/76 , C07D241/20 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08
Abstract: Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
Abstract translation: 提供了氨基杂芳基化合物，以及它们的合成和使用方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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Patent Agency Ranking
2.发明申请Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors 审中-公开吡唑取代的氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US20060128724A1
公开(公告)日：2006-06-15
申请号：US11213039
申请日：2005-08-26
Applicant: Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
Inventor： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC: A61K31/496 , A61K31/4439 , C07D403/02
CPC classification number: C07D401/14 , C07D401/04
Abstract: Compounds of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
Abstract translation: 提供式1的化合物，以及其合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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3.发明申请Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors 有权对映异构纯氨基杂芳基化合物作为蛋白激酶抑制剂公开(公告)号：US20060046991A1
公开(公告)日：2006-03-02
申请号：US11212331
申请日：2005-08-26
Applicant: Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
Inventor： Jingrong Cui , Lee Funk , Lei Jia , Pei-Pei Kung , Jerry Meng , Mitchell Nambu , Mason Pairish , Hong Shen , Michelle Tran-Dube
IPC: A61K31/4965 , C07D213/72 , C07D241/20
CPC classification number: C07D403/04 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K45/06 , C07D213/73 , C07D213/76 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14
Abstract: Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.
Abstract translation: 提供了对映异构体纯的式1化合物，以及它们合成和使用的方法。 优选的化合物是c-Met蛋白激酶的有效抑制剂，并且可用于治疗异常细胞生长障碍如癌症。
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公开(公告)号：US20050154056A1
公开(公告)日：2005-07-14
申请号：US10981128
申请日：2004-11-03
Applicant: Fan Yang , Bo Zhang , Nancy Wicnienski , Jeffrey Pfefferkorn , Meredith Greene , Ke Chen , Richard Nugent , Matthew Reding , Robert Kelly , Mark Mitchell , Lee Funk , Richard Heier , Rebecca Anderson
Inventor： Fan Yang , Bo Zhang , Nancy Wicnienski , Jeffrey Pfefferkorn , Meredith Greene , Ke Chen , Richard Nugent , Matthew Reding , Robert Kelly , Mark Mitchell , Lee Funk , Richard Heier , Rebecca Anderson
IPC: A61K31/255 , A61K31/335 , C07C251/86 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C311/49 , C07C317/28 , C07C317/32 , C07C317/44 , C07C323/62 , C07D207/277 , C07D207/337 , C07D209/18 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/18 , C07D233/28 , C07D233/64 , C07D263/32 , C07D277/32 , C07D285/14 , C07D307/24 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/34 , C07D409/04 , C07D413/04 , C07C39/46
CPC classification number: C07C251/86 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C311/49 , C07C317/28 , C07C317/32 , C07C317/44 , C07C323/62 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D207/277 , C07D207/337 , C07D209/18 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/18 , C07D233/28 , C07D233/64 , C07D263/32 , C07D277/32 , C07D285/14 , C07D307/24 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/34 , C07D409/04 , C07D413/04
Abstract: The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.
Abstract translation: 本发明涉及化合物，其合成方法，用于治疗和预防丙型肝炎病毒（HCV）感染的组合物和方法。 特别地，本发明提供新型化合物，含有这些化合物的药物组合物和使用这些化合物治疗或预防HCV感染的方法。 本发明还提供了合成这些化合物的方法和中间体。
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公开(公告)号：US20050009840A1
公开(公告)日：2005-01-13
申请号：US10786610
申请日：2004-02-26
Applicant: Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
Inventor： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC: A61K20060101 , A61K31/44 , A61K31/496 , A61K31/4965 , A61K31/497 , C07D20060101 , C07D211/72 , C07D213/73 , C07D401/00 , C07D401/12 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D413/12 , C07D417/00 , C07D419/00 , C07
CPC classification number: C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
Abstract translation: 提供式（1）的氨基吡啶和氨基吡嗪化合物，包括这些化合物的组合物及其使用方法。 优选的式1化合物具有作为蛋白激酶抑制剂的活性，包括作为c-MET的抑制剂。
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公开(公告)号：US20070072874A1
公开(公告)日：2007-03-29
申请号：US11598765
申请日：2006-11-14
Applicant: Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
Inventor： Jingrong Cui , Dilip Bhumralkar , Iriny Botrous , Ji Chu , Lee Funk , Cathleen Hanau , G. Harris , Lei Jia , Joanne Johnson , Stephen Kolodziej , Pei-Pei Kung , Xiaoyuan Li , Jason Lin , Jerry Meng , Mitchell Nambu , Christopher Nelson , Mason Pairish , Hong Shen , Michelle Tran-Dube , Allison Walter , Fang-Jie Zhang , Jennifer Zhang
IPC: A61K31/4965 , A61K31/497 , A61K31/4439 , A61K31/4412 , C07D403/02
CPC classification number: C07D213/73 , A61K45/06 , C07D401/12 , C07D413/12
Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.
Abstract translation: 提供式（
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