公开(公告)号：US20160077035A1

公开(公告)日：2016-03-17

申请号：US14955776

申请日：2015-12-01

申请人： Hitachi High-Technologies Corporation

发明人： Hiroshi KANEMOTO ,  Hauro AKAHOSHI ,  So OGUCHI ,  Kenta IMAI ,  Taku SAKAZUME ,  Hiroshi YOSHIDA

IPC分类号： G01N27/30 ,  G01N27/403

CPC分类号： G01N27/307 ,  C25B11/0426 ,  C25B11/0431 ,  C25B11/0473 ,  C25B11/0484 ,  C25F3/16 ,  C25F7/00 ,  G01N27/30 ,  G01N27/3271 ,  G01N27/403 ,  G01N33/4915 ,  H01M4/92 ,  H01M4/921 ,  H01M4/923 ,  H01M4/925

摘要： Provided are an electrode, an electrolysis cell, and an electrochemical analyzer that improve the long-term stability of analysis data. A working electrode, a counter electrode, and reference electrode are disposed in an electrolysis cell. The working electrode is obtained by forming a lead wire in a composite material having platinum or a platinum alloy as a base material, in which a metal oxide is dispersed, or in a laminated material obtained by laminating a valve metal and platinum such that the cross sectional crystal texture in the thickness direction of the platinum is formed in layers and the thickness of each layer of the platinum is 5 micrometers or less. The metal oxide is selected from among zirconium oxide, tantalum oxide, and niobium oxide, and the metal oxide content of the platinum or the platinum alloy is 0.005 to 1 wt % in terms of the zirconium, tantalum, or niobium metal.

公开(公告)号：US20170299548A1

公开(公告)日：2017-10-19

申请号：US15517333

申请日：2015-10-14

申请人： Hitachi High-Technologies Corporation

发明人： Hiroshi YOSHIDA ,  Rena AKAHORI ,  Takanobu HAGA

IPC分类号： G01N27/447 ,  C12Q1/68

CPC分类号： G01N27/44791 ,  B82Y15/00 ,  B82Y40/00 ,  C12Q1/6869 ,  G01N33/48721

摘要： The present invention provides: a nucleic acid delivery controlling system in which a novel delay principle is utilized to greatly delay the nanopore passing rate of a nucleic acid strand, thereby enabling the stable analysis of a nucleotide sequence; a method for manufacturing the nucleic acid delivery controlling system; and a nucleic acid sequencing device. The present invention relates to a nucleic acid delivery controlling system, equipped with a passage through which a nucleic acid strand can pass, said nucleic acid delivery controlling system being characterized in that the passage through which a nucleic acid strand can pass has at least one nanochannel having multiple passages per one nanopore through which only one molecule of the nucleic acid strand can pass, the nanochannel has a microphase-separated structure composed of a block copolymer that is composed of a hydrophobic polymer chain and a hydrophilic polymer chain, and the nanochannel contains the hydrophilic polymer chain of the block copolymer as the main component.

公开(公告)号：US20160244823A1

公开(公告)日：2016-08-25

申请号：US15029712

申请日：2014-11-04

申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION

发明人： Hiroshi YOSHIDA ,  Rena AKAHORI ,  Yasuhiko TADA ,  Shohei TERADA ,  Takanobu HAGA ,  Takashi ANAZAWA

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6869 ,  C12Q1/6872 ,  G01N33/48721 ,  G01N2015/0038 ,  C12Q2565/631 ,  C12Q2565/632

摘要： The purpose of the present invention is to provide a DNA transport control device having excellent reliability and durability, and a DNA sequencing device that uses the DNA transport control device. The present invention provides a DNA transport control device having a nanopore which allows for the passage of only the DNA strand of a single molecule, and a DNA sequencing device that uses the DNA transport control device. The DNA transport control device is characterized by the following: including a base material having openings and a thin film a block copolymer formed on the base material; the thin film including microdomains that are formed as a result of self-assembly of the block copolymer and that penetrate the thin film, and a matrix surrounding the microdomains; and the nanopore being formed from one opening in the base material and a single microdomain.

摘要翻译： 本发明的目的是提供具有优异的可靠性和耐久性的DNA转运控制装置和使用DNA转运控制装置的DNA测序装置。 本发明提供了具有仅允许单个分子的DNA链通过的纳米孔的DNA转运控制装置，以及使用该DNA转运控制装置的DNA测序装置。 DNA转运控制装置的特征在于：包括具有开口的基材和形成在基材上的嵌段共聚物的薄膜; 该薄膜包括由于嵌段共聚物的自组装而形成的并且穿透薄膜的微区域和围绕该微区域的基体; 并且纳米孔由基材中的一个开口和单个微区形成。