公开(公告)号：US20190064535A1

公开(公告)日：2019-02-28

申请号：US16077507

申请日：2016-02-22

Applicant: Hitachi High-Technologies Corporation

Inventor： Takashi ANAZAWA ,  Motohiro YAMAZAKI

IPC: G02B27/14 ,  G01J3/36 ,  G01J3/02 ,  G02B19/00

Abstract: A dichroic mirror array in which a plurality of dichroic mirrors are arranged, and by satisfying a predetermined relationship between a width, a thickness, a material, a tilt, an interval, and a step difference of each dichroic mirror, the dichroic mirror array is miniaturized, an optical path length is reduced, and at the same time, an opening width is increased.

公开(公告)号：US20180024061A1

公开(公告)日：2018-01-25

申请号：US15548432

申请日：2015-02-03

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi ANAZAWA ,  Satoshi TAKAHASHI ,  Motohiro YAMAZAKI ,  Yoshitaka KODAMA

IPC: G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6452 ,  C12Q1/6869 ,  G01J3/4406 ,  G01N21/6428 ,  G01N27/447 ,  G01N27/44721 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6478

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

公开(公告)号：US20190383742A1

公开(公告)日：2019-12-19

申请号：US16480333

申请日：2017-02-20

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi ANAZAWA

IPC: G01N21/64 ,  G01N27/447

Abstract: An analysis system includes an analyzer configured to separate a sample including a plurality of components labeled with any of M kinds of fluorescent substances by chromatography and acquire first time-series data of fluorescence signals detected in N kinds (M>N) of wavelength bands in a state in which at least a part of the plurality of components is not completely separated; and a computer configured to compare the first time-series data with the second time-series data, and determine which kind of fluorescent substance of M kinds of fluorescent substances individually labels each of the plurality of components.

公开(公告)号：US20170212052A1

公开(公告)日：2017-07-27

申请号：US15324149

申请日：2015-06-23

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi ANAZAWA ,  Yoshitaka KODAMA ,  Motohiro YAMAZAKI ,  Kunio HARADA

IPC: G01N21/64 ,  G01N21/01

CPC classification number: G01N21/6454 ,  B01L3/5027 ,  B01L2300/0861 ,  B01L2300/0877 ,  B01L2300/168 ,  G01N21/01 ,  G01N21/05 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6463 ,  G01N2201/06113

Abstract: A laser beam 6 irradiated from a side face of a microchip 1 in which plural channels 2 fill ed with a member of a refractive index n2 in an inner portion of a member of a refractive index n1 (n2 lower base, and is deviated swiftly from a channel array. Hence, the laser beam 6 is made to be deviated gradually from the channel array by irradiating the laser beam 6 from the side face of the microchip 1 by being inclined relative to the same plane in a direction of being directed from the lower base to the upper base. As a result, a larger number of the channels 2 can efficiently be subjected to laser beam irradiation.

公开(公告)号：US20210190689A1

公开(公告)日：2021-06-24

申请号：US16076212

申请日：2016-02-22

Applicant: Hitachi High-Technologies Corporation

Inventor： Takashi ANAZAWA ,  Motohiro YAMAZAKI

IPC: G01N21/64 ,  G02B3/00 ,  G02B27/14 ,  C12Q1/6869

Abstract: The invention is directed to a light-emission detection apparatus for individually condensing light emitted from each emission point of a emission-point array using each condensing lens of a condensing-lens array to form a light beam and detecting each light beam incident on a sensor in parallel, and the light-emission detection apparatus can be downsized and high sensitivity and low crosstalk can be simultaneously accomplished when a certain relation between the diameter of each emission point, a focal length of each condensing lens, an interval of condensing lenses, and an optical path length between each condensing lens and a sensor is satisfied.

公开(公告)号：US20190107491A1

公开(公告)日：2019-04-11

申请号：US16205362

申请日：2018-11-30

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi ANAZAWA ,  Satoshi TAKAHASHI ,  Motohiro YAMAZAKI ,  Yoshitaka KODAMA

IPC: G01N21/64 ,  G01J3/44 ,  G01N27/447 ,  C12Q1/6869

CPC classification number: G01N21/6452 ,  C12Q1/6869 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/14 ,  G01J3/18 ,  G01J3/4406 ,  G01J2003/1217 ,  G01N21/6428 ,  G01N27/447 ,  G01N27/44721 ,  G01N2021/6441 ,  G01N2021/6471 ,  G01N2021/6478

Abstract: A multicolor detection device includes: a condensing lens array 17 in which a plurality of condensing lenses 18, each of which turns light emitted from each of a plurality of light emitting points 1 individually into parallel light beams, are arranged, the light emitting points being arranged in a light emitting point array; at least one spectroscopic element on which the parallel light beams are incident in parallel, the at least one spectroscopic element being common; and at least one sensor on which light beams spectrally separated by the spectroscopic element are incident in parallel, the at least one sensor being common.

公开(公告)号：US20210190725A1

公开(公告)日：2021-06-24

申请号：US16755069

申请日：2018-10-09

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Takashi ANAZAWA ,  Kunio HARADA ,  Motohiro YAMAZAKI

IPC: G01N27/447

Abstract: In order to provide a piston and a syringe with good sliding performance and pressure resistance performance, the piston contained in the syringe that pressurizes or decompresses an internal medium is configured such that a soft portion made of a soft material and a rigid portion made of a material having rigidity higher than rigidity of the soft portion, are connected in series, and arranged such that the soft portion is in contact with the medium and the rigid portion is not in contact with the medium. The soft portion includes a hollow on a surface in contact with the medium. The rigid portion has an end surface facing the soft portion, the end surface including at least an outer peripheral portion in contact with the soft portion. The outer diameter of the soft portion is larger than the outer diameter of the rigid portion, and the outer diameter of the rigid portion is slightly smaller than the inner diameter of an outer cylinder of the syringe.

公开(公告)号：US20160244823A1

公开(公告)日：2016-08-25

申请号：US15029712

申请日：2014-11-04

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Hiroshi YOSHIDA ,  Rena AKAHORI ,  Yasuhiko TADA ,  Shohei TERADA ,  Takanobu HAGA ,  Takashi ANAZAWA

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q1/6872 ,  G01N33/48721 ,  G01N2015/0038 ,  C12Q2565/631 ,  C12Q2565/632

Abstract: The purpose of the present invention is to provide a DNA transport control device having excellent reliability and durability, and a DNA sequencing device that uses the DNA transport control device. The present invention provides a DNA transport control device having a nanopore which allows for the passage of only the DNA strand of a single molecule, and a DNA sequencing device that uses the DNA transport control device. The DNA transport control device is characterized by the following: including a base material having openings and a thin film a block copolymer formed on the base material; the thin film including microdomains that are formed as a result of self-assembly of the block copolymer and that penetrate the thin film, and a matrix surrounding the microdomains; and the nanopore being formed from one opening in the base material and a single microdomain.

Abstract translation: 本发明的目的是提供具有优异的可靠性和耐久性的DNA转运控制装置和使用DNA转运控制装置的DNA测序装置。 本发明提供了具有仅允许单个分子的DNA链通过的纳米孔的DNA转运控制装置，以及使用该DNA转运控制装置的DNA测序装置。 DNA转运控制装置的特征在于：包括具有开口的基材和形成在基材上的嵌段共聚物的薄膜; 该薄膜包括由于嵌段共聚物的自组装而形成的并且穿透薄膜的微区域和围绕该微区域的基体; 并且纳米孔由基材中的一个开口和单个微区形成。